Abstract:
:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functional in IECs. Our approach enables human enteroids to be used for novel in vitro studies into IEC MHC-II regulation and function during health and disease.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins EDdoi
10.3389/fimmu.2019.01970subject
Has Abstractpub_date
2019-08-20 00:00:00pages
1970issn
1664-3224journal_volume
10pub_type
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