Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.

abstract：:Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is an SLE risk gene of previously unknown function. We undertook the pre...

journal_title：Frontiers in immunology

authors： Harris VM,Koelsch KA,Kurien BT,Harley ITW,Wren JD,Harley JB,Scofield RH

更新日期：2019-10-21 00:00:00

abstract：:Among kidney transplant recipients, the treatment of choice for acute T cell-mediated rejection (TCMR) with pulse steroids or antibody protocols has variable outcomes. Some rejection episodes are resistant to an initial steroid pulse, but respond to subsequent antibody protocols. The biological mechanisms causing the ...

journal_title：Frontiers in immunology

authors： Kadota PO,Hajjiri Z,Finn PW,Perkins DL

更新日期：2015-11-06 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombos...

journal_title：Frontiers in immunology

authors： Tektonidou MG

更新日期：2018-05-31 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:The NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory ...

journal_title：Frontiers in immunology

authors： Kordaß T,Osen W,Eichmüller SB

更新日期：2018-04-18 00:00:00

abstract：:The recombinant adeno-associated virus (rAAV) gene delivery system is entering a crucial and exciting phase with the promise of more than 20 years of intense research now realized in a number of successful human clinical trials. However, as a natural host to AAV infection, anti-AAV antibodies are prevalent in the huma...

journal_title：Frontiers in immunology

authors： Tseng YS,Agbandje-McKenna M

更新日期：2014-01-30 00:00:00

abstract：:We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

journal_title：Frontiers in immunology

authors： Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

更新日期：2013-09-03 00:00:00

abstract：:Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-03-03 00:00:00

abstract：:Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

journal_title：Frontiers in immunology

authors： Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

更新日期：2019-03-05 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00

abstract：:Novel adjuvant technologies have a key role in the development of next-generation vaccines, due to their capacity to modulate the duration, strength and quality of the immune response. The AS01 adjuvant is used in the malaria vaccine RTS,S/AS01 and in the licensed herpes-zoster vaccine (Shingrix) where the vaccine has...

journal_title：Frontiers in immunology

authors： Buckley PR,Alden K,Coccia M,Chalon A,Collignon C,Temmerman ST,Didierlaurent AM,van der Most R,Timmis J,Andersen CA,Coles MC

更新日期：2019-09-12 00:00:00

abstract：:Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Interestingly, there is...

journal_title：Frontiers in immunology

authors： Wijnsma KL,Veissi ST,de Wijs S,van der Velden T,Volokhina EB,Wagener FADTG,van de Kar NCAJ,van den Heuvel LP

更新日期：2020-12-22 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:Over the past two decades, heat shock proteins (HSPs) have been implicated in inflammatory responses and autoimmunity. HSPs were originally believed to maintain protein quality control in the cytosol. However, they also exist extracellularly and appear to act as inflammatory factors. Recently, a growing body of eviden...

journal_title：Frontiers in immunology

authors： Morito D,Nagata K

更新日期：2012-03-15 00:00:00

abstract：Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

journal_title：Frontiers in immunology

authors： Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

更新日期：2020-11-24 00:00:00

abstract：:Background: Optimal timing of gestational tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not well-defined. No well-established specific anti-pertussis antibody level correlates with protection, suggesting the importance of antibody quality such as avidity. We aimed to determine the effect of timing of va...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Giles ML,Kollmann TR,Sadarangani M

更新日期：2019-10-11 00:00:00

abstract：:C-reactive protein (CRP), a humoral component of the innate immune system with important functions in host-defense, is extensively used as a sensitive biomarker of systemic inflammation. During inflammation, hepatocyte-derived CRP rises dramatically in the blood due to increased interleukin-6 (IL-6) levels. Reliable d...

journal_title：Frontiers in immunology

authors： Wetterö J,von Löhneysen S,Cobar F,Kristenson M,Garvin P,Sjöwall C

更新日期：2021-01-08 00:00:00

abstract：:Newborns are prone to fungal infections, largely due to Candida species. The immunological basis for this vulnerability is not yet fully understood. However, useful insights can be gained from the knowledge of the maturation of immune pathways during ontogeny, particularly when placed in context with how rare genetic ...

journal_title：Frontiers in immunology

authors： Michalski C,Kan B,Lavoie PM

更新日期：2017-03-15 00:00:00

abstract：:Immunotherapies based on natural killer (NK) cells are among the most promising therapies under development for the treatment of so far incurable forms of leukemia and other types of cancer. The importance of NK cells for the control of viral infections and cancer is supported among others by the findings that viruses...

journal_title：Frontiers in immunology

authors： Hofer E,Koehl U

更新日期：2017-07-12 00:00:00

abstract：:HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical ...

journal_title：Frontiers in immunology

authors： Westrop SJ,Cocker ATH,Boasso A,Sullivan AK,Nelson MR,Imami N

更新日期：2017-06-27 00:00:00

abstract：:Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to tailor these alterations in gene expression to the requirements of the inflammatory process, tight and coordinate regulation of gene expression by environmental cues, microbial or danger-associated molecules or cytokines, are m...

journal_title：Frontiers in immunology

authors： Platanitis E,Decker T

更新日期：2018-11-13 00:00:00

abstract：:Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

journal_title：Frontiers in immunology

authors： Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

更新日期：2018-11-01 00:00:00

abstract：:Alterations in the energy homeostasis contribute to sepsis-mediated multiple organ failure. The liver plays a central role in metabolism and participates to the innate immune and inflammatory responses of sepsis. Several clinical and experimental studies have suggested that females are less susceptible to the adverse ...

journal_title：Frontiers in immunology

authors： Kikuchi S,Piraino G,O'Connor M,Wolfe V,Ridings K,Lahni P,Zingarelli B

更新日期：2020-02-13 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in cancer thera...

journal_title：Frontiers in immunology

authors： Zeng QZ,Yang F,Li CG,Xu LH,He XH,Mai FY,Zeng CY,Zhang CC,Zha QB,Ouyang DY

更新日期：2019-01-29 00:00:00

abstract：:Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in th...

journal_title：Frontiers in immunology

authors： Goronzy JJ,Li G,Yang Z,Weyand CM

更新日期：2013-06-04 00:00:00

abstract：:Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as well as staphylococ...

journal_title：Frontiers in immunology

authors： Kale SD,Mehrkens BN,Stegman MM,Kastelberg B,Carnes H,McNeill RJ,Rizzo A,Karyala SV,Coutermarsh-Ott S,Fretz JA,Sun Y,Koff JL,Rajagopalan G

更新日期：2020-06-26 00:00:00

abstract：:Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8+ T cells to differentiate to effector and memory cells. Leaving the resting state requires dramatic changes of chromatin status in the key cell cycle inhibitors but the details of these concerted events are no...

journal_title：Frontiers in immunology

authors： Chen G,Subedi K,Chakraborty S,Sharov A,Lu J,Kim J,Mi X,Wersto R,Sung MH,Weng NP

更新日期：2018-03-26 00:00:00

abstract：OBJECTIVE:Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of R. h...

journal_title：Frontiers in immunology

authors： Patterson AM,Mulder IE,Travis AJ,Lan A,Cerf-Bensussan N,Gaboriau-Routhiau V,Garden K,Logan E,Delday MI,Coutts AGP,Monnais E,Ferraria VC,Inoue R,Grant G,Aminov RI

更新日期：2017-09-26 00:00:00