Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages.

abstract：:Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance p...

journal_title：Frontiers in immunology

authors： Hammoudeh SM,Venkatachalam T,Ansari AW,Bendardaf R,Hamid Q,Rahmani M,Hamoudi R

更新日期：2020-12-14 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:Arboviruses (arthropod-borne viruses), such as Zika (ZIKV), West Nile (WNV), and dengue (DENV) virus, include some of the most significant global health risks to human populations. The steady increase in the number of cases is of great concern due to the debilitating diseases associated with each viral infection. Beca...

journal_title：Frontiers in immunology

authors： Trammell CE,Goodman AG

更新日期：2019-12-20 00:00:00

abstract：:TNFAIP3 encodes the NF-κB regulatory protein A20. High-penetrance heterozygous mutations in TNFAIP3 cause a haploinsufficiency of A20 (HA20), inadequate inhibition of NF-κB pathway, and an early onset autoinflammatory disorder. However, the clinical phenotype of patients with HA20 varies greatly and clinical diagnoses...

journal_title：Frontiers in immunology

authors： Lawless D,Pathak S,Scambler TE,Ouboussad L,Anwar R,Savic S

更新日期：2018-07-04 00:00:00

abstract：:We consider the problem of self-tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B-lymphocytes of the same idiotype, which is encoded by a bit string. The links of the network connect nodes with (nearly) complementary strings. The population of ...

journal_title：Frontiers in immunology

authors： Schulz R,Werner B,Behn U

更新日期：2014-03-10 00:00:00

abstract：:[This corrects the article on p. 125 in vol. 6, PMID: 25852693.]. ...

journal_title：Frontiers in immunology

authors： Dalai SK,Yadav N,Patidar M,Patel H,Singh AP

更新日期：2015-06-22 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

journal_title：Frontiers in immunology

authors： Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

更新日期：2019-09-20 00:00:00

abstract：:Highly sensitive reporter-gene assays have been developed that allow both the direct vascular endothelial growth factor (VEGF) neutralizing activity of bevacizumab and the ability of bevacizumab to activate antibody dependent cellular cytotoxicity (ADCC) to be quantified rapidly and in a highly specific manner. The us...

journal_title：Frontiers in immunology

authors： Lallemand C,Ferrando-Miguel R,Auer M,Iglseder S,Czech T,Gaber-Wagener A,Di Pauli F,Deisenhammer F,Tovey MG

更新日期：2020-10-15 00:00:00

abstract：:Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of...

journal_title：Frontiers in immunology

authors： Vo HTM,Baudner BC,Sammicheli S,Iannacone M,D'Oro U,Piccioli D

更新日期：2018-04-09 00:00:00

abstract：:Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole...

journal_title：Frontiers in immunology

authors： Kim WH,Lillehoj HS,Min W

更新日期：2019-03-26 00:00:00

abstract：:This is the first case of NBAS disease detected by NBS for primary immunodeficiency. NBS with KRECs is revealing unknown potentialities detecting conditions that benefit from early recognition like NBAS deficiency. Immune phenotyping should be mandatory in patients with NBAS deficiency since they can exhibit severe im...

journal_title：Frontiers in immunology

authors： Ricci S,Lodi L,Serranti D,Moroni M,Belli G,Mancano G,La Barbera A,Forzano G,Mangone G,Indolfi G,Azzari C

更新日期：2019-08-27 00:00:00

abstract：:Natural antibodies are spontaneously produced in the absence of infection or immunization, and are both anti-microbial and autoreactive. Autoreactive natural antibodies can bind noxious molecules, such as those involved in clinical situations of atherosclerosis (oxLDL), malignancy (NGcGM3), and neurodegeneration (amyl...

journal_title：Frontiers in immunology

authors： Rothstein TL

更新日期：2016-04-07 00:00:00

abstract：:As we have suggested, epigenetic factors, such as microRNAs (miRNAs), can interact with genetic programs to regulate B cell functions, thereby informing antibody and autoantibody responses. We have shown that histone deacetylase (HDAC) inhibitors (HDI) inhibit the differentiation events critical to the maturation of t...

journal_title：Frontiers in immunology

authors： Shen T,Sanchez HN,Zan H,Casali P

更新日期：2015-12-14 00:00:00

abstract：:iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and protects against cancer in vivo. Monoclonal antibodies (mAbs) that detec...

journal_title：Frontiers in immunology

authors： Clark K,Yau J,Bloom A,Wang J,Venzon DJ,Suzuki M,Pasquet L,Compton BJ,Cardell SL,Porcelli SA,Painter GF,Zajonc DM,Berzofsky JA,Terabe M

更新日期：2019-10-09 00:00:00

abstract：:Allergic asthma is a chronic Th2 inflammatory disease of the lower airways affecting a growing number of people worldwide. The impact of infections and microbiota composition on allergic asthma has been investigated frequently. Until now, however, there have been few attempts to investigate the impact of asthma on the...

journal_title：Frontiers in immunology

authors： Machelart A,Potemberg G,Van Maele L,Demars A,Lagneaux M,De Trez C,Sabatel C,Bureau F,De Prins S,Percier P,Denis O,Jurion F,Romano M,Vanderwinden JM,Letesson JJ,Muraille E

更新日期：2018-08-10 00:00:00

abstract：:The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved therapeutics do not ...

journal_title：Frontiers in immunology

authors： Sharma V,Wright KL,Epling-Burnette PK,Reuther GW

更新日期：2020-11-30 00:00:00

abstract：:Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is ...

journal_title：Frontiers in immunology

authors： Son S,Shim DW,Hwang I,Park JH,Yu JW

更新日期：2019-05-16 00:00:00

abstract：:Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

journal_title：Frontiers in immunology

authors： Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

更新日期：2018-10-16 00:00:00

abstract：:Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in the world, with more than 100 million cases reported annually. While there have been extensive studies into the adverse effects that CT infection has on the female genital tract, and on the subsequent ability of these women to...

journal_title：Frontiers in immunology

authors： Redgrove KA,McLaughlin EA

更新日期：2014-10-27 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：:The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, which is located near ...

journal_title：Frontiers in immunology

authors： Sun Y,Liu Z,Li Z,Lian Z,Zhao Y

更新日期：2012-12-20 00:00:00

abstract：:Regulatory T cells play an important role in the control of autoimmune diseases and maintenance of tolerance. In the context of transplantation, regulatory T cells (Tregs) have been proposed as new therapeutic tools that may induce allospecific tolerance toward the graft, avoiding the side effects induced by generaliz...

journal_title：Frontiers in immunology

authors： Alvarez-Salazar EK,Cortés-Hernández A,Arteaga-Cruz S,Alberú-Gómez J,Soldevila G

更新日期：2020-04-02 00:00:00

abstract：:Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be beneficial. Here...

journal_title：Frontiers in immunology

authors： Al Azzaz J,Rieu A,Aires V,Delmas D,Chluba J,Winckler P,Bringer MA,Lamarche J,Vervandier-Fasseur D,Dalle F,Lapaquette P,Guzzo J

更新日期：2019-01-14 00:00:00

abstract：:The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using ...

journal_title：Frontiers in immunology

authors： Arulraj T,Binder SC,Robert PA,Meyer-Hermann M

更新日期：2019-09-06 00:00:00

abstract：:Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma ...

journal_title：Frontiers in immunology

authors： Carsetti R,Di Sabatino A,Rosado MM,Cascioli S,Piano Mortari E,Milito C,Grimsholm O,Aranburu A,Giorda E,Tinozzi FP,Pulvirenti F,Donato G,Morini F,Bagolan P,Corazza GR,Quinti I

更新日期：2020-01-08 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate those environmental cues, orchestrate immunity or tolerance, and regulate tissue homeostasis. Recent advances in the field of immunometabo...

journal_title：Frontiers in immunology

authors： Wculek SK,Khouili SC,Priego E,Heras-Murillo I,Sancho D

更新日期：2019-04-25 00:00:00

abstract：Background:The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods:This was a single ...

journal_title：Frontiers in immunology

authors： Spinella PC,Thomas KA,Turnbull IR,Fuchs A,Bochicchio K,Schuerer D,Reese S,Coleoglou Centeno AA,Horn CB,Baty J,Shea SM,Meledeo MA,Pusateri AE,Levy JH,Cap AP,Bochicchio GV,TAMPITI Investigators.

更新日期：2020-09-08 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host macrophages, which might be a key mediator of virus induced inflam...

journal_title：Frontiers in immunology

authors： Nayak TK,Mamidi P,Sahoo SS,Kumar PS,Mahish C,Chatterjee S,Subudhi BB,Chattopadhyay S,Chattopadhyay S

更新日期：2019-04-12 00:00:00