The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells.

abstract：:Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige...

journal_title：Frontiers in immunology

authors： Chaurasia B,Talbot CL,Summers SA

更新日期：2020-09-23 00:00:00

abstract：:Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

journal_title：Frontiers in immunology

authors： Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

更新日期：2020-02-14 00:00:00

abstract：:The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM comp...

journal_title：Frontiers in immunology

authors： Lu HY,Bauman BM,Arjunaraja S,Dorjbal B,Milner JD,Snow AL,Turvey SE

更新日期：2018-09-19 00:00:00

abstract：:Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indo...

journal_title：Frontiers in immunology

authors： Hornyák L,Dobos N,Koncz G,Karányi Z,Páll D,Szabó Z,Halmos G,Székvölgyi L

更新日期：2018-01-31 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00

abstract：:This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that t...

journal_title：Frontiers in immunology

authors： Machelart A,Van Vyve M,Potemberg G,Demars A,De Trez C,Tima HG,Vanwalleghem G,Romano M,Truyens C,Letesson JJ,Muraille E

更新日期：2017-07-31 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：:[This corrects the article on p. 299 in vol. 6, PMID: 26150816.]. ...

journal_title：Frontiers in immunology

authors： Frontiers Production Office.

更新日期：2016-04-28 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：Objective:Antiphospholipid syndrome (APS) is characterized by the presence of anti-phospholipid (aPL) antibodies. However, the relationship between the immunoglobulin (Ig) A isotype of aPL positivity and its clinical utility in APS diagnosis is controversial. Presently, we determine the clinical utility of IgA-aPL from...

journal_title：Frontiers in immunology

authors： Hu C,Li X,Zhao J,Wang Q,Li M,Tian X,Zeng X

更新日期：2020-10-05 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00

abstract：:Schnitzler syndrome (SchS) is a rare autoinflammatory disease, characterized by urticarial rash, recurrent fever, osteo-articular pain/arthritis with bone condensation, and monoclonal gammopathy. Diagnosis may be difficult due to overlapping signs with other diseases. Here, we describe the case of a 62-year-old man wi...

journal_title：Frontiers in immunology

authors： Hodl I,Bosch P,Dreo B,Stradner MH

更新日期：2020-09-30 00:00:00

abstract：:In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing...

journal_title：Frontiers in immunology

authors： Maueröder C,Mahajan A,Paulus S,Gößwein S,Hahn J,Kienhöfer D,Biermann MH,Tripal P,Friedrich RP,Munoz LE,Neurath MF,Becker C,Schett GA,Herrmann M,Leppkes M

更新日期：2016-12-09 00:00:00

abstract：:Ischemia reperfusion injury (IRI) is linked with inflammation in kidney transplantation (ktx). The chemokine CXCL13, also known as B lymphocyte chemoattractant, mediates recruitment of B cells within follicles of lymphoid tissues and has recently been identified as a biomarker for acute kidney allograft rejection. The...

journal_title：Frontiers in immunology

authors： Kreimann K,Jang MS,Rong S,Greite R,von Vietinghoff S,Schmitt R,Bräsen JH,Schiffer L,Gerstenberg J,Vijayan V,Dittrich-Breiholz O,Wang L,Karsten CM,Gwinner W,Haller H,Immenschuh S,Gueler F

更新日期：2020-08-06 00:00:00

abstract：:A growing number of diseases in humans, including trauma, certain cancers, and infection, are known to be associated with l-arginine deficiency. In addition, l-arginine must be supplemented by diet during pregnancy to aid fetal development. In conditions of l-arginine depletion, T cell proliferation is impaired. We ha...

journal_title：Frontiers in immunology

authors： Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

更新日期：2017-04-25 00:00:00

abstract：:Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isola...

journal_title：Frontiers in immunology

authors： Eggenhofer E,Benseler V,Kroemer A,Popp FC,Geissler EK,Schlitt HJ,Baan CC,Dahlke MH,Hoogduijn MJ

更新日期：2012-09-26 00:00:00

abstract：:Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...

journal_title：Frontiers in immunology

authors： Esposito S,Stefanelli P,Fry NK,Fedele G,He Q,Paterson P,Tan T,Knuf M,Rodrigo C,Weil Olivier C,Flanagan KL,Hung I,Lutsar I,Edwards K,O'Ryan M,Principi N,World Association of Infectious Diseases and Immunological Disorders

更新日期：2019-07-03 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airway. Its major symptoms are reversible breathing problems causing airway narrowing and obstruction. IL-19 is a member of the IL-10 family cytokines. We previously showed that IL-19 induces T-helper 2 (Th2) cytokines and that asthma patients had higher serum IL-19 leve...

journal_title：Frontiers in immunology

authors： Weng YH,Chen WY,Lin YL,Wang JY,Chang MS

更新日期：2019-04-30 00:00:00

abstract：:Ninety percent of those diagnosed with systemic lupus erythematosus are female, with peak incidence between the ages of 15 and 45, when women are most hormonally active. Despite significant research effort, the mechanisms underlying this sex bias remain unclear. We previously showed that a functional knockout of estro...

journal_title：Frontiers in immunology

authors： Cunningham MA,Wirth JR,Scott JL,Eudaly J,Collins EL,Gilkeson GS

更新日期：2016-02-15 00:00:00

abstract：:Peste des petits ruminants virus (PPRV) has emerged as a significant threat to the productivity of small ruminants worldwide. PPRV is lymphotropic in nature and induces in the hosts a transient but severe immunosuppression, especially innate immunity. However, it remains largely unknown how NK cells respond and are re...

journal_title：Frontiers in immunology

authors： Qi X,Li Z,Li H,Wang T,Zhang Y,Wang J

更新日期：2020-01-23 00:00:00

abstract：:A major limitation to the translation of tolerogenic therapies to clinical transplantation is a lack of biomarkers that can be used as surrogate measures for predicting the successful induction of immune tolerance which would allow for the safe withdrawal of immunosuppression. We have used three different mouse models...

journal_title：Frontiers in immunology

authors： Cobbold SP,Adams E,Waldmann H

更新日期：2011-04-06 00:00:00

abstract：:Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified. While the initia...

journal_title：Frontiers in immunology

authors： Rawat A,Arora K,Shandilya J,Vignesh P,Suri D,Kaur G,Rikhi R,Joshi V,Das J,Mathew B,Singh S

更新日期：2019-09-11 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopon...

journal_title：Frontiers in immunology

authors： Scutera S,Salvi V,Lorenzi L,Piersigilli G,Lonardi S,Alotto D,Casarin S,Castagnoli C,Dander E,D'Amico G,Sozzani S,Musso T

更新日期：2018-06-01 00:00:00

abstract：:In the last few years, there has been a twist in cancer treatment toward immunotherapy thanks to the impressive results seen in advanced patients from several tumor pathologies. Cutaneous melanoma is a highly mutated and immunogenic tumor that has been a test field for the development of immunotherapy. However, there ...

journal_title：Frontiers in immunology

authors： Aris M,Mordoh J,Barrio MM

更新日期：2017-08-25 00:00:00

abstract：:Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR) repertoires through next-generation sequencing is providing excellent insights into the understanding of adaptive immune responses. Variable(Diversity)Joining [V(D)J] germline genes and alleles must be characterized in detail to fac...

journal_title：Frontiers in immunology

authors： Zhang W,Wang IM,Wang C,Lin L,Chai X,Wu J,Bett AJ,Dhanasekaran G,Casimiro DR,Liu X

更新日期：2016-11-04 00:00:00

abstract：:Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

journal_title：Frontiers in immunology

authors： Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

更新日期：2018-06-11 00:00:00

abstract：:The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial...

journal_title：Frontiers in immunology

authors： Xu HY,Dong F,Zhai X,Meng KF,Han GK,Cheng GF,Wu ZB,Li N,Xu Z

更新日期：2020-09-23 00:00:00