Abstract：
:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing tolerance to other solid organs that would normally otherwise be rejected. Although this phenomenon is less pronounced in human liver transplantation, lower levels of immunosuppression are nevertheless required for graft acceptance than for other solid organs, and in a minority of individuals immunosuppression can be discontinued in the longer term. The mechanisms underlying this unique hepatic property have not yet been fully delineated, however it is clear that immunological events in the early period post-liver transplant are key to generation of hepatic allograft tolerance. Both the hepatic parenchyma and the large number of donor passenger leukocytes contained within the liver allograft have been demonstrated to contribute to the generation of donor-specific tolerance in the early post-transplant phase. In particular, the unique nature of hepatic-leukocyte interactions appears to play a crucial role in the ability of the liver to silence the recipient alloimmune response. In this review, we will summarize the evidence regarding the potential mechanisms that mediate the critical early phase in the generation of hepatic allograft tolerance.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
McCaughan GW,Bowen DG,Bertolino PJdoi
10.3389/fimmu.2020.01908subject
Has Abstractpub_date
2020-09-11 00:00:00pages
1908issn
1664-3224journal_volume
11pub_type
杂志文章,评审abstract：:Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin. The pathomechanism of blister formation in PF is unknown. Previously we have shown that PF IgG induces aggregation of DSG1,...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.02635
更新日期：2019-11-12 00:00:00
abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.01297
更新日期：2017-10-23 00:00:00
abstract：:By uncovering complex dynamics in the expression or localization of transcriptional regulators in single cells that were otherwise hidden at the population level, live cell imaging has transformed our understanding of how cells sense and orchestrate appropriate responses to changes in their internal state or extracell...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.02962
更新日期：2018-12-14 00:00:00
abstract：:Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used in vitro macrophage...
journal_title：Frontiers in immunology
pub_type： 杂志文章,meta分析
doi：10.3389/fimmu.2019.02887
更新日期：2019-12-11 00:00:00
abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2015.00543
更新日期：2015-11-02 00:00:00
abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.02467
更新日期：2019-10-25 00:00:00
abstract：:Targeting the programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) pathway has been shown to enhance T cell-mediated antitumor immunity. Clinical responses are limited to subgroups of patients. The search for biomarkers of response is a strategy to predict response and outcome of PD-1/PD-L1 checkpoint interventi...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01769
更新日期：2018-07-30 00:00:00
abstract：:Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its role in the pathogenes...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01243
更新日期：2019-06-04 00:00:00
abstract：:Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.00646
更新日期：2019-03-29 00:00:00
abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2019.03009
更新日期：2019-12-23 00:00:00
abstract：:Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells. They promote the activation of innate myeloid immune cells since they contribute...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2019.02037
更新日期：2019-08-28 00:00:00
abstract：:TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2017.01243
更新日期：2017-10-03 00:00:00
abstract：:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.00478
更新日期：2020-03-25 00:00:00
abstract：:Long lasting antibody responses and immunological memory are the desired outcomes of vaccination. In general, multiple vaccine doses result in enhanced immune responses, a notable exception being booster-induced hyporesponsiveness, which has been observed with polysaccharide and glycoconjugate vaccines. In this study,...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.00508
更新日期：2019-03-19 00:00:00
abstract：:Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pat...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.02596
更新日期：2018-11-20 00:00:00
abstract：:The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TRGs in patients with AD a...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.00012
更新日期：2020-01-29 00:00:00
abstract：:Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment in solid tumors as well as infectious foci with persistent pathogens promotes the development and recruitment of MRC...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.01895
更新日期：2018-01-04 00:00:00
abstract：:The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming osteoblasts. These two cell types are fundamentally different in terms of progenitor cells, mode of action and regulation by specific molecules, acting either systemically or locally. Importantly, there is increasing evidence for an...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2019.02182
更新日期：2019-09-13 00:00:00
abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.00380
更新日期：2018-03-12 00:00:00
abstract：:The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to supportive care, disease severity, potential for recovery, and, if n...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.610861
更新日期：2021-01-15 00:00:00
abstract：:Blood-feeding enriched gut-microbiota boosts mosquitoes' anti-Plasmodium immunity. Here, we ask how Plasmodium vivax alters gut-microbiota, anti-Plasmodial immunity, and impacts tripartite Plasmodium-mosquito-microbiota interactions in the gut lumen. We used a metagenomics and RNAseq strategy to address these question...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.00609
更新日期：2020-05-14 00:00:00
abstract：:The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promoti...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2020.01450
更新日期：2020-07-09 00:00:00
abstract：:In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a coronary artery. A similar phenomenon is observed in heart transplantation (HTx) when, after cold storage, the donor heart is connected to ...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2020.599511
更新日期：2020-12-08 00:00:00
abstract：Objective:Antiphospholipid syndrome (APS) is characterized by the presence of anti-phospholipid (aPL) antibodies. However, the relationship between the immunoglobulin (Ig) A isotype of aPL positivity and its clinical utility in APS diagnosis is controversial. Presently, we determine the clinical utility of IgA-aPL from...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.568503
更新日期：2020-10-05 00:00:00
abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01039
更新日期：2019-05-08 00:00:00
abstract：:Donor-specific blood transfusion (DST) can lead to significant prolongation of allograft survival in experimental animal models and sometimes human recipients of solid organs. The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and are not yet ful...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2017.00009
更新日期：2017-02-21 00:00:00
abstract：:Interleukin-10 plays important, yet contrasting, roles in host protection against bacterial infections and in the septic response. To determine the role of IL-10 in the host defense against Acinetobacter baumannii infection, wild-type (WT) and IL-10-deficient mice were infected intranasally with the bacteria. IL-10-de...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.00270
更新日期：2020-02-21 00:00:00
abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.00368
更新日期：2020-03-19 00:00:00
abstract：:Monoclonal antibody (mAb)-based therapeutics are the fastest growing class of human pharmaceuticals. They are typically IgG1 molecules with N-glycans attached to the N297 residue on crystallizable fragment (Fc). Different Fc glycoforms impact their effector function, pharmacokinetics, stability, aggregation, safety, a...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.01554
更新日期：2017-11-13 00:00:00
abstract：:Increasing studies have highlighted the effects of the tumor immune micro-environment (TIM) on colon cancer (CC) tumorigenesis, prognosis, and metastasis. However, there is no reliable molecular marker that can effectively estimate the immune infiltration and predict the CC relapse risk. Here, we leveraged the gene ex...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.01678
更新日期：2020-09-03 00:00:00
