Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism.


:The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental identification of host-parasite molecular interactions remains challenging, and the use of computational predictions becomes then necessary. Here, we propose a computational integrative approach to predict host-parasite protein-protein interaction (PPI) networks resulting from the human infection by 15 different eukaryotic parasites. We used an orthology-based approach to transfer high-confidence intraspecies interactions obtained from the STRING database to the corresponding interspecies homolog protein pairs in the host-parasite system. Our approach uses either the parasites predicted secretome and membrane proteins, or only the secretome, depending on whether they are uni- or multi-cellular, respectively, to reduce the number of false predictions. Moreover, the host proteome is filtered for proteins expressed in selected cellular localizations and tissues supporting the parasite growth. We evaluated the inferred interactions by analyzing the enriched biological processes and pathways in the predicted networks and their association with known parasitic invasion and evasion mechanisms. The resulting PPI networks were compared across parasites to identify common mechanisms that may define a global pathogenic hallmark. We also provided a study case focusing on a closer examination of the human-S. mansoni predicted interactome, detecting central proteins that have relevant roles in the human-S. mansoni network, and identifying tissue-specific interactions with key roles in the life cycle of the parasite. The predicted PPI networks can be visualized and downloaded at


Front Immunol


Frontiers in immunology


Cuesta-Astroz Y,Santos A,Oliveira G,Jensen LJ




Has Abstract


2019-02-13 00:00:00








  • Sialylated Cervical Mucins Inhibit the Activation of Neutrophils to Form Neutrophil Extracellular Traps in Bovine in vitro Model.

    abstract::In order to combat invading pathogens neutrophils can release neutrophil extracellular traps (NETs). However, since NETs can also damage endogenous cells, several control mechanisms for the formation of NETs must work effectively. For instance, neutrophil activation is silenced within blood circulation by the binding ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bornhöfft KF,Rebl A,Gallagher ME,Viergutz T,Zlatina K,Reid C,Galuska SP

    更新日期:2019-11-06 00:00:00

  • Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities.

    abstract::Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitor...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Xiang Z,Tu W

    更新日期:2017-08-28 00:00:00

  • Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen.

    abstract::Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

    更新日期:2018-06-11 00:00:00

  • Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?

    abstract::Intravenous IgG (IVIg) contains polyclonal immunoglobulin G (IgG) from thousands of donors. It is administered at a low dose at regular intervals as antibody replacement therapy and at a higher dose as immunomodulatory treatment in various auto-immune or auto-inflammatory diseases. The working mechanism of immunomodul...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Nagelkerke SQ,Kuijpers TW

    更新日期:2015-01-21 00:00:00

  • Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses.

    abstract::About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. Intriguingly, HERV...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Grandi N,Tramontano E

    更新日期:2018-09-10 00:00:00

  • Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis.

    abstract::Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ndlovu H,Marakalala MJ

    更新日期:2016-10-24 00:00:00

  • MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1.

    abstract::Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to healthy controls (HC). Methods: CD1c-expressing cDC2s were isolated from ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lopes AP,van Roon JAG,Blokland SLM,Wang M,Chouri E,Hartgring SAY,van der Wurff-Jacobs KMG,Kruize AA,Burgering BMT,Rossato M,Radstake TRDJ,Hillen MR

    更新日期:2019-06-20 00:00:00

  • A critical analysis of rejection in vascularized composite allotransplantation: clinical, cellular and molecular aspects, current challenges, and novel concepts.

    abstract::Advances in microsurgical techniques and immunomodulatory protocols have contributed to the expansion of vascularized composite allotransplantation (VCA) with very encouraging immunological, functional, and cosmetic results. Rejection remains however a major hurdle that portends serious threats to recipients. Rejectio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sarhane KA,Tuffaha SH,Broyles JM,Ibrahim AE,Khalifian S,Baltodano P,Santiago GF,Alrakan M,Ibrahim Z

    更新日期:2013-11-25 00:00:00

  • Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance.

    abstract::The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

    更新日期:2015-11-23 00:00:00

  • Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires.

    abstract::Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

    更新日期:2019-01-15 00:00:00

  • Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts.

    abstract::There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

    更新日期:2018-12-11 00:00:00

  • Gut Microbiota and Bacterial DNA Suppress Autoimmunity by Stimulating Regulatory B Cells in a Murine Model of Lupus.

    abstract::Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We previously showed the suppressive effect of vancomycin treatment during the "active-disease" stage ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mu Q,Edwards MR,Swartwout BK,Cabana Puig X,Mao J,Zhu J,Grieco J,Cecere TE,Prakash M,Reilly CM,Puglisi C,Bachali P,Grammer AC,Lipsky PE,Luo XM

    更新日期:2020-11-10 00:00:00

  • Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone.

    abstract::pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Naffah de Souza C,Breda LCD,Khan MA,de Almeida SR,Câmara NOS,Sweezey N,Palaniyar N

    更新日期:2018-01-09 00:00:00

  • Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics.

    abstract::The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promoti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mellors J,Tipton T,Longet S,Carroll M

    更新日期:2020-07-09 00:00:00

  • A Role for Dogs in Advancing Cancer Immunotherapy Research.

    abstract::While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Dow S

    更新日期:2020-01-17 00:00:00

  • Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies.

    abstract::Neutrophil extracellular traps (NETs) are chromatin filaments decorated with enzymes from neutrophil cytoplasmic granules. Anti-neutrophil cytoplasmic antibodies (ANCAs) bind to enzymes from neutrophil cytoplasmic granules and are biomarkers for the diagnosis of systemic vasculitides. ANCA diagnostics are based on ind...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Panda R,Krieger T,Hopf L,Renné T,Haag F,Röber N,Conrad K,Csernok E,Fuchs TA

    更新日期:2017-04-13 00:00:00

  • Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Cro

    abstract:Background:The aging process leads to a potential decline in immune function and adversely affects the gut microbiota. To date, many in vitro and in vivo studies focused on the application of synbiotics (prebiotics combined with probiotics) as a promising dietary approach to affect gut microbiota composition and improv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Costabile A,Bergillos-Meca T,Rasinkangas P,Korpela K,de Vos WM,Gibson GR

    更新日期:2017-12-12 00:00:00

  • Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery.

    abstract::Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bouvier I,Jusforgues-Saklani H,Lim A,Lemaître F,Lemercier B,Auriau C,Nicola MA,Leroy S,Law HK,Bandeira A,Moon JJ,Bousso P,Albert ML

    更新日期:2011-12-08 00:00:00

  • Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

    更新日期:2019-09-20 00:00:00

  • Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid.

    abstract::Recent studies suggest an important role of immunoglobulin E (IgE) as an alternative pathogenic pathway in the development of bullous pemphigoid (BP), as the most frequent subepidermal blistering disease of the skin Use of IgE targeted therapies, such as omalizumab, has been shown promising in recent studies. The aim ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Seyed Jafari SM,Gadaldi K,Feldmeyer L,Yawalkar N,Borradori L,Schlapbach C

    更新日期:2019-08-14 00:00:00

  • Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.

    abstract::Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adjuvant principle. How...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schubert N,Lisenko K,Auerbach C,Weitzmann A,Ghouse SM,Muhandes L,Haase C,Häring T,Schulze L,Voehringer D,Gunzer F,Müller W,Feyerabend TB,Rodewald HR,Dudeck A,Roers A

    更新日期:2018-08-28 00:00:00

  • Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation.

    abstract::Ischemia reperfusion injury (IRI) is linked with inflammation in kidney transplantation (ktx). The chemokine CXCL13, also known as B lymphocyte chemoattractant, mediates recruitment of B cells within follicles of lymphoid tissues and has recently been identified as a biomarker for acute kidney allograft rejection. The...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kreimann K,Jang MS,Rong S,Greite R,von Vietinghoff S,Schmitt R,Bräsen JH,Schiffer L,Gerstenberg J,Vijayan V,Dittrich-Breiholz O,Wang L,Karsten CM,Gwinner W,Haller H,Immenschuh S,Gueler F

    更新日期:2020-08-06 00:00:00

  • Interplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in Leukemia.

    abstract::The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription fact...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Brettingham-Moore KH,Taberlay PC,Holloway AF

    更新日期:2015-09-29 00:00:00

  • The Role of TLR2 in Infection and Immunity.

    abstract::Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Oliveira-Nascimento L,Massari P,Wetzler LM

    更新日期:2012-04-18 00:00:00

  • Zinc Oxide Nanowires Exposure Induces a Distinct Inflammatory Response via CCL11-Mediated Eosinophil Recruitment.

    abstract::High aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most important products in nanotechnology. The wide range applications of ZnONWs have heightened the need for evaluating the risks and biological consequences to these particles. In this study, we investigated inflammatory pathways activated by ZnO...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Alghsham RS,Satpathy SR,Bodduluri SR,Hegde B,Jala VR,Twal W,Burlison JA,Sunkara M,Haribabu B

    更新日期:2019-11-08 00:00:00

  • Modulation of Chemokine Responses: Synergy and Cooperativity.

    abstract::Chemokine biology is mediated by more complex interactions than simple monomolecular ligand-receptor interactions, as chemokines can form higher order quaternary structures, which can also be formed after binding to glycosaminoglycans (GAGs) on endothelial cells, and their receptors are found as dimers and/or oligomer...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Proudfoot AE,Uguccioni M

    更新日期:2016-05-19 00:00:00

  • Cysteine Cathepsins in Tumor-Associated Immune Cells.

    abstract::Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells. They promote the activation of innate myeloid immune cells since they contribute...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Jakoš T,Pišlar A,Jewett A,Kos J

    更新日期:2019-08-28 00:00:00

  • TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells.

    abstract::B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can also be immunogenic in certain contexts and can incite aberrant acti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Suthers AN,Sarantopoulos S

    更新日期:2017-07-13 00:00:00

  • Identifying the Presence of Prostate Cancer in Individuals with PSA Levels

    abstract::Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

    更新日期:2017-12-18 00:00:00

  • Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation.

    abstract::Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

    更新日期:2020-10-22 00:00:00