Beyond IgE-When Do IgE-Crosslinking and Effector Cell Activation Lead to Clinical Anaphylaxis?

abstract：:β-glucan, the most abundant fungal cell wall polysaccharide, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study of this molecule has been motivated by its importance as a pathogen-associated molecular pattern upon fungal...

journal_title：Frontiers in immunology

authors： Camilli G,Tabouret G,Quintin J

更新日期：2018-04-16 00:00:00

abstract：:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inacti...

journal_title：Frontiers in immunology

authors： Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JAS

更新日期：2019-04-18 00:00:00

abstract：:Dendritic cells (DC), master antigen-presenting cells that orchestrate interactions between the adaptive and innate immune arms, are increasingly utilized in cancer immunotherapy. Despite remarkable progress in our understanding of DC immunobiology, as well as several encouraging clinical applications - such as DC-bas...

journal_title：Frontiers in immunology

authors： Datta J,Berk E,Cintolo JA,Xu S,Roses RE,Czerniecki BJ

更新日期：2015-06-02 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects of single supply or...

journal_title：Frontiers in immunology

authors： Nhu TQ,Bich Hang BT,Cornet V,Oger M,Bach LT,Anh Dao NL,Thanh Huong DT,Quetin-Leclercq J,Scippo ML,Phuong NT,Kestemont P

更新日期：2020-05-05 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：:We aimed to explore the prognostic value of blood leukocyte and to generate a predictive model to refine risk stratification for colorectal cancers. 6,558 patients with colorectal cancers were identified eligible respectively in Fudan University Shanghai Cancer Center (FUSCC) between May, 2008 and October, 2016. Then ...

journal_title：Frontiers in immunology

authors： Hu X,Li YQ,Li QG,Ma YL,Peng JJ,Cai SJ

更新日期：2018-10-12 00:00:00

abstract：:Monocytes in humans consist of 3 subsets; CD14+CD16- (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14+CD16- monocytes are significantly elevated and migrate to the sites of injury via the adhesion c...

journal_title：Frontiers in immunology

authors： Lee MKS,Al-Sharea A,Shihata WA,Bertuzzo Veiga C,Cooney OD,Fleetwood AJ,Flynn MC,Claeson E,Palmer CS,Lancaster GI,Henstridge DC,Hamilton JA,Murphy AJ

更新日期：2019-09-06 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:The mucosal immune system is constantly exposed to antigen, whether it be food antigen, commensal bacteria, or harmful antigen. It is essential that the mucosal immune system can distinguish between harmful and non-harmful antigens, and initiate an active immune response to clear the harmful antigens, while initiating...

journal_title：Frontiers in immunology

authors： Lambert SE,Kinder JM,Then JE,Parliament KN,Bruns HA

更新日期：2012-07-18 00:00:00

abstract：:Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

journal_title：Frontiers in immunology

authors： Liu R,Nikolajczyk BS

更新日期：2019-07-17 00:00:00

abstract：:Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations ...

journal_title：Frontiers in immunology

authors： Von Holle TA,Moody MA

更新日期：2019-06-25 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate on the origin of IL-10-secreting B cells and lack of specific surface markers has turned into an important obstacle for studying human B regulatory cells. In t...

journal_title：Frontiers in immunology

authors： Ticha O,Moos L,Wajant H,Bekeredjian-Ding I

更新日期：2018-01-19 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:The NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory ...

journal_title：Frontiers in immunology

authors： Kordaß T,Osen W,Eichmüller SB

更新日期：2018-04-18 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) work through silencing of differentiated antigen-specific T cells, activation and expansion of naturally occurring T regulatory cells (Tregs), transfer of regulatory properties to T cells, and the differentiation of naïve T cells into Tregs. Due to an operational definition based on T...

journal_title：Frontiers in immunology

authors： Nikolic T,Roep BO

更新日期：2013-05-14 00:00:00

abstract：:Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, ...

journal_title：Frontiers in immunology

authors： Morrison MC,Kleemann R

更新日期：2015-06-15 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the ligand-independent ...

journal_title：Frontiers in immunology

authors： Greaves SA,Peterson JN,Torres RM,Pelanda R

更新日期：2018-04-09 00:00:00

abstract：:The adaptive immune system generates an incredible diversity of antigen receptors for B and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these receptors arise by a complex recombination process followed by a series of productivity-based filters, as well as affinity maturation for B cells, g...

journal_title：Frontiers in immunology

authors： Olson BJ,Moghimi P,Schramm CA,Obraztsova A,Ralph D,Vander Heiden JA,Shugay M,Shepherd AJ,Lees W,Matsen FA 4th

更新日期：2019-11-01 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

journal_title：Frontiers in immunology

authors： Cong J,Wei H

更新日期：2019-06-25 00:00:00

abstract：:Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombos...

journal_title：Frontiers in immunology

authors： Tektonidou MG

更新日期：2018-05-31 00:00:00

abstract：:Autoimmune bullous dermatoses (AIBD) include a series of typical organ-specific autoimmune diseases characterized by extensive mucocutaneous blisters. It is generally accepted to be caused by pathological autoantibodies that directly target specific adhesion components of the skin or the adjacent mucous membranes. Bot...

journal_title：Frontiers in immunology

authors： Cao T,Shao S,Fang H,Li B,Wang G

更新日期：2019-08-02 00:00:00

abstract：:Glioblastoma (GBM) is the most malignant form of astrocytoma with short survival and a high recurrence rate and remains a global problem. Currently, surgery, chemotherapy, radiotherapy, and other comprehensive treatments are the main treatment modalities, but patients still have a poor prognosis mainly due to the infi...

journal_title：Frontiers in immunology

authors： Kang X,Zheng Y,Hong W,Chen X,Li H,Huang B,Huang Z,Tang H,Geng W

更新日期：2020-10-21 00:00:00

abstract：:Stromal cells are a subject of rapidly growing immunological interest based on their ability to influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue, stromal cells complement the functions of classical immune cells by sensing pathogens and tissue damage, coordinating leukocyt...

journal_title：Frontiers in immunology

authors： West NR

更新日期：2019-05-15 00:00:00