sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation.

abstract：:Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomav...

journal_title：Frontiers in immunology

authors： Wang C,Dickie J,Sutavani RV,Pointer C,Thomas GJ,Savelyeva N

更新日期：2018-04-23 00:00:00

abstract：:The lung is a primary organ for gas exchange in mammals that represents the largest epithelial surface in direct contact with the external environment. It also serves as a crucial immune organ, which harbors both innate and adaptive immune cells to induce a potent immune response. Due to its direct contact with the ou...

journal_title：Frontiers in immunology

authors： Kumar V

更新日期：2020-08-04 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of action may provide useful insights for their clinical application. The goal ...

journal_title：Frontiers in immunology

authors： Binder C,Sellberg F,Cvetkovski F,Berglund E,Berglund D

更新日期：2020-11-11 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

journal_title：Frontiers in immunology

authors： Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

更新日期：2020-07-16 00:00:00

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00

abstract：:In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker for cross-presenting DC in the spleen. Now, we provide evidence that i...

journal_title：Frontiers in immunology

authors： Becker M,Güttler S,Bachem A,Hartung E,Mora A,Jäkel A,Hutloff A,Henn V,Mages HW,Gurka S,Kroczek RA

更新日期：2014-07-28 00:00:00

abstract：:Among kidney transplant recipients, the treatment of choice for acute T cell-mediated rejection (TCMR) with pulse steroids or antibody protocols has variable outcomes. Some rejection episodes are resistant to an initial steroid pulse, but respond to subsequent antibody protocols. The biological mechanisms causing the ...

journal_title：Frontiers in immunology

authors： Kadota PO,Hajjiri Z,Finn PW,Perkins DL

更新日期：2015-11-06 00:00:00

abstract：:System dynamics is a powerful tool that allows modeling of complex and highly networked systems such as those found in the human immune system. We have developed a model that reproduces how the exposure of human monocytes to lipopolysaccharides (LPSs) induces an inflammatory state characterized by high production of t...

journal_title：Frontiers in immunology

authors： Álvarez E,Toledano V,Morilla F,Hernández-Jiménez E,Cubillos-Zapata C,Varela-Serrano A,Casas-Martín J,Avendaño-Ortiz J,Aguirre LA,Arnalich F,Maroun-Eid C,Martín-Quirós A,Quintana Díaz M,López-Collazo E

更新日期：2017-08-03 00:00:00

abstract：:Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as well as staphylococ...

journal_title：Frontiers in immunology

authors： Kale SD,Mehrkens BN,Stegman MM,Kastelberg B,Carnes H,McNeill RJ,Rizzo A,Karyala SV,Coutermarsh-Ott S,Fretz JA,Sun Y,Koff JL,Rajagopalan G

更新日期：2020-06-26 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：Background:Selenium (Se) levels decrease in the circulation during acute inflammatory states and sepsis, and are inversely associated with morbidity and mortality. A more specific understanding of where selenoproteins and Se processing are compromised during insult is needed. We investigated the acute signaling respons...

journal_title：Frontiers in immunology

authors： Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

更新日期：2020-11-05 00:00:00

abstract：:Chimeric antigen receptor (CAR)-engineered T cells represent a breakthrough in personalized medicine. In this strategy, a patient's own T lymphocytes are genetically reprogrammed to encode a synthetic receptor that binds a tumor antigen, allowing T cells to recognize and kill antigen-expressing cancer cells. As a resu...

journal_title：Frontiers in immunology

authors： Long KB,Young RM,Boesteanu AC,Davis MM,Melenhorst JJ,Lacey SF,DeGaramo DA,Levine BL,Fraietta JA

更新日期：2018-12-03 00:00:00

abstract：:Dendritic epidermal T cells (DETCs) and dermal Vγ4 T cells engage in wound re-epithelialization and skin inflammation. However, it remains unknown whether a functional link between Vγ4 T cell pro-inflammation and DETC pro-healing exists to affect the outcome of skin wound closure. Here, we revealed that Vγ4 T cell-der...

journal_title：Frontiers in immunology

authors： Li Y,Wang Y,Zhou L,Liu M,Liang G,Yan R,Jiang Y,Hao J,Zhang X,Hu X,Huang Y,Wang R,Yin Z,Wu J,Luo G,He W

更新日期：2018-02-12 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

journal_title：Frontiers in immunology

authors： Petre B

更新日期：2020-08-21 00:00:00

abstract：:Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in fibrosis remain poorly understood. Epigenetics refers to alterations of gene expression without changes in the DNA sequence. Alternation o...

journal_title：Frontiers in immunology

authors： Hu L,Yu Y,Huang H,Fan H,Hu L,Yin C,Li K,Fulton DJ,Chen F

更新日期：2017-01-30 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:Background: Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. T...

journal_title：Frontiers in immunology

authors： Cussotto S,Delgado I,Anesi A,Dexpert S,Aubert A,Beau C,Forestier D,Ledaguenel P,Magne E,Mattivi F,Capuron L

更新日期：2020-04-15 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined...

journal_title：Frontiers in immunology

authors： Yang L,Fu J,Zhou Y

更新日期：2020-08-27 00:00:00

abstract：:Glioblastoma is one of the most common neoplasms in the central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction of the tumor cells, possess a pivotal regulation capability in the tumor microenvironment with a superior proliferation ...

journal_title：Frontiers in immunology

authors： Zhai Y,Li G,Li R,Chang Y,Feng Y,Wang D,Wu F,Zhang W

更新日期：2020-10-08 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the cardiovascular system. Atherosclerosis is the most common cardiovascular complication of SLE and a significant risk factor for morbidity and mortality. Vascular damage/protection mechanism in SLE patients is out of balance, caused by...

journal_title：Frontiers in immunology

authors： Ding X,Xiang W,He X

更新日期：2020-11-11 00:00:00

abstract：:Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our...

journal_title：Frontiers in immunology

authors： Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

更新日期：2020-10-22 00:00:00

abstract：:The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various...

journal_title：Frontiers in immunology

authors： Motran CC,Silvane L,Chiapello LS,Theumer MG,Ambrosio LF,Volpini X,Celias DP,Cervi L

更新日期：2018-04-04 00:00:00

abstract：:Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against thi...

journal_title：Frontiers in immunology

authors： Chauhan N,Khatri V,Banerjee P,Kalyanasundaram R

更新日期：2018-07-02 00:00:00

abstract：:Vaccination against Salmonella Typhi using the Vi capsular polysaccharide, a T-cell independent antigen, can protect from the development of typhoid fever. This implies that antibodies to Vi alone can protect in the absence of a T cell-mediated immune response; however, protective Vi antibodies have not been well-char...

journal_title：Frontiers in immunology

authors： Dahora LC,Jin C,Spreng RL,Feely F,Mathura R,Seaton KE,Zhang L,Hill J,Jones E,Alam SM,Dennison SM,Pollard AJ,Tomaras GD

更新日期：2019-11-01 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00