Toward the Discovery of Host-Defense Peptides in Plants.

abstract：:Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...

journal_title：Frontiers in immunology

authors： Esposito S,Stefanelli P,Fry NK,Fedele G,He Q,Paterson P,Tan T,Knuf M,Rodrigo C,Weil Olivier C,Flanagan KL,Hung I,Lutsar I,Edwards K,O'Ryan M,Principi N,World Association of Infectious Diseases and Immunological Disorders

更新日期：2019-07-03 00:00:00

abstract：:Understanding the mechanisms of human immunodeficiency virus type I (HIV-1) pathogenesis would facilitate the identification of new therapeutic targets to control the infection in face of current antiretroviral therapy limitations. CD74 membrane expression is upregulated in HIV-1-infected cells and the magnitude of it...

journal_title：Frontiers in immunology

authors： Trifone C,Salido J,Ruiz MJ,Leng L,Quiroga MF,Salomón H,Bucala R,Ghiglione Y,Turk G

更新日期：2018-06-27 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural...

journal_title：Frontiers in immunology

authors： López-Botet M,Vilches C,Redondo-Pachón D,Muntasell A,Pupuleku A,Yélamos J,Pascual J,Crespo M

更新日期：2017-02-16 00:00:00

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00

abstract：:It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

journal_title：Frontiers in immunology

authors： Sehrawat S,Rouse BT

更新日期：2017-04-03 00:00:00

abstract：:It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports...

journal_title：Frontiers in immunology

authors： Dhainaut M,Moser M

更新日期：2014-03-28 00:00:00

abstract：:T cells recognizing epitopes on the surface of mycobacteria-infected macrophages can impart protection, but with associated risk for reactivation to lung pathology. We aimed to identify antibodies specific to such epitopes, which carry potentials for development toward novel therapeutic constructs. Since epitopes pres...

journal_title：Frontiers in immunology

authors： Ortega PA,Silva-Miranda M,Torres-Larios A,Campos-Chávez E,Franken KCLCM,Ottenhoff THM,Ivanyi J,Espitia C

更新日期：2020-10-02 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Richter's syndrome), ...

journal_title：Frontiers in immunology

authors： Märklin M,Fuchs AR,Tandler C,Heitmann JS,Salih HR,Kauer J,Quintanilla-Martinez L,Wirths S,Kopp HG,Müller MR

更新日期：2020-09-02 00:00:00

abstract：:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) ...

journal_title：Frontiers in immunology

authors： Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ

更新日期：2019-01-10 00:00:00

abstract：:Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding ...

journal_title：Frontiers in immunology

authors： Granofszky N,Farkas AM,Muckenhuber M,Mahr B,Unger L,Maschke S,Pilat N,Holly R,Wiletel M,Regele H,Wekerle T

更新日期：2017-07-19 00:00:00

abstract：:The host immune response to gastrointestinal (GI) infections, hypersensitivity reactions, or GI cancers comprises numerous pathways that elicit responses on different host cells. Some of these include (1) the stimulation of mast cells via their IgE receptor, (2) the production of antibodies leading to antibody-mediate...

journal_title：Frontiers in immunology

authors： El-Zaatari M,Kao JY

更新日期：2017-01-27 00:00:00

abstract：:Aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of natural and synthetic agents, modulates the activity of immune cells in the gut and represents an important link between the environment and immune-mediated pathologies. In this study, we investigated the role of AhR in celiac disea...

journal_title：Frontiers in immunology

authors： Dinallo V,Marafini I,Di Fusco D,Di Grazia A,Laudisi F,Dwairi R,Paoluzi OA,Monteleone G,Monteleone I

更新日期：2019-02-04 00:00:00

abstract：:Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

journal_title：Frontiers in immunology

authors： Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

更新日期：2020-12-23 00:00:00

abstract：:CD4+ T cells comprise multiple functionally distinct cell populations that play a key role in immunity. Despite blood monitoring of CD4+ T-cell subsets is of potential clinical utility, no standardized and validated approaches have been proposed so far. The aim of this study was to design and validate a single 14-colo...

journal_title：Frontiers in immunology

authors： Botafogo V,Pérez-Andres M,Jara-Acevedo M,Bárcena P,Grigore G,Hernández-Delgado A,Damasceno D,Comans S,Blanco E,Romero A,Arriba-Méndez S,Gastaca-Abasolo I,Pedreira CE,van Gaans-van den Brink JAM,Corbiere V,Mascart F,van El

更新日期：2020-02-27 00:00:00

abstract：:Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations ...

journal_title：Frontiers in immunology

authors： Von Holle TA,Moody MA

更新日期：2019-06-25 00:00:00

abstract：:B cell activation via the B cell receptor (BCR) signalosome involves participation of signaling molecules such as BTK and BLNK. Genetic defects in these molecules are known to impair B cell differentiation and subsequently lead to agammaglobulinemia. Here we identified novel mutations in BTK and BLNK in two unrelated ...

journal_title：Frontiers in immunology

authors： Geier CB,Sauerwein KMT,Leiss-Piller A,Zmek I,Fischer MB,Eibl MM,Wolf HM

更新日期：2018-12-18 00:00:00

abstract：:B-cell expansion with NF-κB and T-cell anergy (BENTA) disease is a B-cell-specific lymphoproliferative disorder caused by germline gain-of-function mutations in CARD11. These mutations force the CARD11 scaffold into an open conformation capable of stimulating constitutive NF-κB activation in lymphocytes, without requi...

journal_title：Frontiers in immunology

authors： Arjunaraja S,Angelus P,Su HC,Snow AL

更新日期：2018-02-08 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...

journal_title：Frontiers in immunology

authors： Dupré L,Houmadi R,Tang C,Rey-Barroso J

更新日期：2015-11-18 00:00:00

abstract：:Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to healthy controls (HC). Methods: CD1c-expressing cDC2s were isolated from ...

journal_title：Frontiers in immunology

authors： Lopes AP,van Roon JAG,Blokland SLM,Wang M,Chouri E,Hartgring SAY,van der Wurff-Jacobs KMG,Kruize AA,Burgering BMT,Rossato M,Radstake TRDJ,Hillen MR

更新日期：2019-06-20 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune inflammatory brain disease that can develop a variety of neuropsychiatric presentations. However, the underlying nature of its inflammatory neuronal injury remains unclear. Mitochondrial DNA (mtDNA) is recently regarded as a damage-associated mol...

journal_title：Frontiers in immunology

authors： Peng Y,Zheng D,Zhang X,Pan S,Ji T,Zhang J,Shen HY,Wang HH

更新日期：2019-02-06 00:00:00

abstract：Introduction:C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isofo...

journal_title：Frontiers in immunology

authors： Thiele JR,Zeller J,Kiefer J,Braig D,Kreuzaler S,Lenz Y,Potempa LA,Grahammer F,Huber TB,Huber-Lang M,Bannasch H,Stark GB,Peter K,Eisenhardt SU

更新日期：2018-04-16 00:00:00

abstract：:Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfun...

journal_title：Frontiers in immunology

authors： Klingemann H,Boissel L,Toneguzzo F

更新日期：2016-03-14 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which is different from linear RNA. CircRNA is an RNA molecule with a closed loop structure formed by reverse splicing. CircRNAs have been studied in several organisms, however, the circRNAs associated with the response to Salmonella enterica serovar En...

journal_title：Frontiers in immunology

authors： Zheng L,Liu L,Lin L,Tang H,Fan X,Lin H,Li X

更新日期：2019-05-31 00:00:00

abstract：:Immunotherapy approaches currently make their way into the clinics to improve the outcome of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) is one possible target that, upon blockade, allows T cell-dependent antitumor immune responses to be executed. To date, it is unclear which R...

journal_title：Frontiers in immunology

authors： Derer A,Spiljar M,Bäumler M,Hecht M,Fietkau R,Frey B,Gaipl US

更新日期：2016-12-22 00:00:00

abstract：:Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets...

journal_title：Frontiers in immunology

authors： Bosseboeuf A,Allain-Maillet S,Mennesson N,Tallet A,Rossi C,Garderet L,Caillot D,Moreau P,Piver E,Girodon F,Perreault H,Brouard S,Nicot A,Bigot-Corbel E,Hermouet S,Harb J

更新日期：2017-10-19 00:00:00

abstract：:TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

journal_title：Frontiers in immunology

authors： Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

更新日期：2019-02-28 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor nec...

journal_title：Frontiers in immunology

authors： Roberts CA,Dickinson AK,Taams LS

更新日期：2015-11-19 00:00:00