Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated...

journal_title：Frontiers in immunology

authors： Carvalho MOS,Souza ALCS,Carvalho MB,Pacheco APAS,Rocha LC,do Nascimento VML,Figueiredo CVB,Guarda CC,Santiago RP,Adekile A,Goncalves MS

更新日期：2017-11-06 00:00:00

abstract：:Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipients; these alloantib...

journal_title：Frontiers in immunology

authors： Richards AL,Sheldon K,Wu X,Gruber DR,Hudson KE

更新日期：2018-10-05 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low pH exposure, shifted the repertoires of specificities in different dir...

journal_title：Frontiers in immunology

authors： Graeter S,Schneider C,Verschoor D,von Däniken S,Seibold F,Yawalkar N,Villiger P,Dimitrov JD,Smith DF,Cummings RD,Simon HU,Vassilev T,von Gunten S

更新日期：2020-05-19 00:00:00

abstract：:Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. CORT is now appreciated to also mediate the neuroimmune-priming effect of stress to innate-immune stimulation, and hence serves a...

journal_title：Frontiers in immunology

authors： Liu J,Mustafa S,Barratt DT,Hutchinson MR

更新日期：2018-01-22 00:00:00

abstract：:Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of rece...

journal_title：Frontiers in immunology

authors： Lin A,Loré K

更新日期：2017-12-11 00:00:00

abstract：:In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and ...

journal_title：Frontiers in immunology

authors： Newmark H,Dantoft W,Ghazal P

更新日期：2017-02-09 00:00:00

abstract：:The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the resistance to Respiratory Syncytial Virus (RSV) infection. In this work, by using macrophages deple...

journal_title：Frontiers in immunology

authors： Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

更新日期：2020-09-29 00:00:00

abstract：:Duck plague virus (DPV) is a representative pathogen transmitted among aquatic animals that causes gross lesions and immune inhibition in geese and ducks. The mechanism of organ tropism and innate immune evasion of DPV has not been completely deciphered due to a lack of cell models to study the innate immune manipulat...

journal_title：Frontiers in immunology

authors： Tian B,Cai D,He T,Deng L,Wu L,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Chen S,Zhang S,Huang J,Ou X,Mao S,Yu Y,Zhang L,Liu Y,Cheng A

更新日期：2020-01-28 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to...

journal_title：Frontiers in immunology

authors： Li A,Song NJ,Riesenberg BP,Li Z

更新日期：2020-02-11 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Tuberculosis (TB) is currently one of the leading causes of global mortality. Medical non-compliance due to the length of the treatment and antibiotic side effects has led to the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (M. tb) that are difficult to treat. A current therapeutic stra...

journal_title：Frontiers in immunology

authors： Hernandez J,Ashley D,Cao R,Abrahem R,Nguyen T,To K,Yegiazaryan A,Akinwale David A,Kumar Tiwari R,Venketaraman V

更新日期：2020-08-13 00:00:00

abstract：:Common variable immunodeficiency (CVID) is increasingly recognized for its association with autoimmune and inflammatory complications. Despite recent advances in immunophenotypic and genetic discovery, clinical care of CVID remains limited by our inability to accurately model risk for non-infectious disease developmen...

journal_title：Frontiers in immunology

authors： Farmer JR,Ong MS,Barmettler S,Yonker LM,Fuleihan R,Sullivan KE,Cunningham-Rundles C,USIDNET Consortium.,Walter JE

更新日期：2018-01-09 00:00:00

abstract：:Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune regulatory functions. Ado can (i) actively be released by various cells into the tissue environment and can (ii) be produced through the degradation of extracellular ATP by the concerted action of CD39 and CD73. In this sequence of ...

journal_title：Frontiers in immunology

authors： Silva-Vilches C,Ring S,Mahnke K

更新日期：2018-11-09 00:00:00

abstract：:Newborns are at significantly increased risk of severe disease following infection with influenza virus. This is the collective result of their naïve status, altered immune responsiveness, and the lack of a vaccine that is effective in these individuals. Numerous studies have revealed impairments in both the innate an...

journal_title：Frontiers in immunology

authors： Alexander-Miller MA

更新日期：2020-09-16 00:00:00

abstract：:Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

journal_title：Frontiers in immunology

authors： Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

更新日期：2016-10-31 00:00:00

abstract：:Interleukin-10 plays important, yet contrasting, roles in host protection against bacterial infections and in the septic response. To determine the role of IL-10 in the host defense against Acinetobacter baumannii infection, wild-type (WT) and IL-10-deficient mice were infected intranasally with the bacteria. IL-10-de...

journal_title：Frontiers in immunology

authors： Kang MJ,Jang AR,Park JY,Ahn JH,Lee TS,Kim DY,Lee MS,Hwang S,Jeong YJ,Park JH

更新日期：2020-02-21 00:00:00

abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

journal_title：Frontiers in immunology

authors： Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

更新日期：2019-05-08 00:00:00

abstract：:The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has generated a significant repercussion on the administration of adoptive cell therapies, including chimeric antigen receptor (CAR) T-cells. The closing of borders, the reduction of people transit and the confinement of the...

journal_title：Frontiers in immunology

authors： Ortiz de Landazuri I,Egri N,Muñoz-Sánchez G,Ortiz-Maldonado V,Bolaño V,Guijarro C,Pascal M,Juan M

更新日期：2020-10-15 00:00:00

abstract：:This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focusing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of Trp degradation. IDO1 has been implicated in regulation of feto-mate...

journal_title：Frontiers in immunology

authors： Sedlmayr P,Blaschitz A,Stocker R

更新日期：2014-05-19 00:00:00

abstract：:Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

journal_title：Frontiers in immunology

authors： Zwaini Z,Alammari D,Byrne S,Stover C

更新日期：2016-03-30 00:00:00

abstract：:Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adjuvant principle. How...

journal_title：Frontiers in immunology

authors： Schubert N,Lisenko K,Auerbach C,Weitzmann A,Ghouse SM,Muhandes L,Haase C,Häring T,Schulze L,Voehringer D,Gunzer F,Müller W,Feyerabend TB,Rodewald HR,Dudeck A,Roers A

更新日期：2018-08-28 00:00:00

abstract：:There is a strong correlation between dysregulation of the gastrointestinal microbiota and development of allergic diseases. The most prevalent therapies for relieving asthma symptoms are associated with serious side effects, and therefore novel approaches are needed. Our objective was to elucidate whether oral admini...

journal_title：Frontiers in immunology

authors： Ghiamati Yazdi F,Zakeri A,van Ark I,Leusink-Muis T,Braber S,Soleimanian-Zad S,Folkerts G

更新日期：2020-06-04 00:00:00

abstract：:Enterovirus and Coxsackievirus are the major viruses that cause hand, foot, and mouth disease (HFMD) outbreaks worldwide. Several studies have shown the potential of viral envelope protein 1 (VP1) on providing protective effects from viral strains of different genotypes. However, whether VP1 has the cross-protection i...

journal_title：Frontiers in immunology

authors： Chen FH,Liu X,Fang HL,Nan N,Li Z,Ning NZ,Luo DY,Li T,Wang H

更新日期：2019-11-08 00:00:00

abstract：:Background: IL-17A has effects on several cell types and is a therapeutic target in several inflammatory diseases. IL-17F shares 50% homology and biological activities with IL-17A. It is now of interest to target both cytokines. The objective was to compare the IL-17A and IL-17F effect on cytokine production by RA syn...

journal_title：Frontiers in immunology

authors： Noack M,Beringer A,Miossec P

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

journal_title：Frontiers in immunology

authors： Katare PB,Bagul PK,Dinda AK,Banerjee SK

更新日期：2017-06-22 00:00:00

abstract：:A successful outcome to pregnancy is dependent on the ability of the maternal uterine microenvironment to regulate inflammation processes and establish maternal tolerance. Recently, B cells have been shown to influence pregnancy outcomes as aberrations in their numbers and functions are associated with obstetric compl...

journal_title：Frontiers in immunology

authors： Guzman-Genuino RM,Eldi P,Garcia-Valtanen P,Hayball JD,Diener KR

更新日期：2019-12-11 00:00:00