The role of placental tryptophan catabolism.

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of new antibiotics is notoriously costly and slow; therefore, alternative strategies are needed. Antimicrobial peptides (AMPs), the central effector molecules of the...

journal_title：Frontiers in immunology

authors： Geitani R,Moubareck CA,Xu Z,Karam Sarkis D,Touqui L

更新日期：2020-06-30 00:00:00

abstract：:The potential of tolerogenic dendritic cells (tolDCs) to shape immune responses and restore tolerance has turn them into a promising therapeutic tool for cellular therapies directed toward immune regulation in autoimmunity. Although the cellular mechanisms by which these cells can exert their regulatory function are w...

journal_title：Frontiers in immunology

authors： García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

更新日期：2019-05-28 00:00:00

abstract：:Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically a...

journal_title：Frontiers in immunology

authors： Lage SL,Longo C,Branco LM,da Costa TB,Buzzo Cde L,Bortoluci KR

更新日期：2014-07-02 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to...

journal_title：Frontiers in immunology

authors： Li A,Song NJ,Riesenberg BP,Li Z

更新日期：2020-02-11 00:00:00

abstract：:Natural killer (NK) cells are known for their well characterized ability to control viral infections and eliminate tumor cells. Through their repertoire of activating and inhibitory receptors, NK cells are able to survey different potential target cells for various surface markers, such as MHC-I - which signals to the...

journal_title：Frontiers in immunology

authors： Tu MM,Mahmoud AB,Makrigiannis AP

更新日期：2016-05-02 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Virus-specific CD4(+) T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4(+) T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used fun...

journal_title：Frontiers in immunology

authors： Lokhande MU,Thimme R,Klenerman P,Semmo N

更新日期：2015-02-25 00:00:00

abstract：:Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Cons...

journal_title：Frontiers in immunology

authors： Saul L,Mair I,Ivens A,Brown P,Samuel K,Campbell JDM,Soong DY,Kamenjarin N,Mellanby RJ

更新日期：2019-03-28 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells. Extracellular HMGB1 has been extensively studied for its prototypical alarmin functions activating innate immunity, after being actively r...

journal_title：Frontiers in immunology

authors： Yang H,Wang H,Andersson U

更新日期：2020-03-20 00:00:00

abstract：:Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5-20%, even while under specific treatment. In humans and other species susceptible to fatal VL, such as dogs...

journal_title：Frontiers in immunology

authors： de Melo CVB,Hermida MD,Mesquita BR,Fontes JLM,Koning JJ,Solcà MDS,Benevides BB,Mota GBS,Freitas LAR,Mebius RE,Dos-Santos WLC

更新日期：2020-04-15 00:00:00

abstract：:The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad capsid is currently being investigated as an alternative approach of vaccination. The present study seeks to better understand virus- and host-related factors controlling the effica...

journal_title：Frontiers in immunology

authors： Anchim A,Raddi N,Zig L,Perrieau P,Le Goffic R,Ryffel B,Benihoud K

更新日期：2018-02-05 00:00:00

abstract：:The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especially in laboratory mice since they are used so heavily to model im...

journal_title：Frontiers in immunology

authors： Kokolus KM,Spangler HM,Povinelli BJ,Farren MR,Lee KP,Repasky EA

更新日期：2014-02-10 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or more after diagnosis. Despite aggressive multimodal therapy, consisting mostly of a combination of surgery, radiotherapy, and temozolomi...

journal_title：Frontiers in immunology

authors： Pearson JRD,Cuzzubbo S,McArthur S,Durrant LG,Adhikaree J,Tinsley CJ,Pockley AG,McArdle SEB

更新日期：2020-10-15 00:00:00

abstract：:Ectodermal dysplasias (ED) are uncommon genetic disorders resulting in abnormalities in ectodermally derived structures. Many ED-associated genes have been described, of which ectodysplasin-A (EDA) is one of the more common. The NF-κB essential modulator (NEMO encoded by the IKBKG gene) is unique in that mutations res...

journal_title：Frontiers in immunology

authors： Keller MD,Petersen M,Ong P,Church J,Risma K,Burham J,Jain A,Stiehm ER,Hanson EP,Uzel G,Deardorff MA,Orange JS

更新日期：2011-11-08 00:00:00

abstract：:NKG2D is a potent activating immunoreceptor expressed on nearly all cytotoxic lymphocytes promoting their cytotoxicity against self-cells expressing NKG2D ligands (NKG2DLs). NKG2DLs are MHC class I-like glycoproteins that usually are not expressed on "healthy" cells. Rather, their surface expression is induced by vari...

journal_title：Frontiers in immunology

authors： Kim Y,Born C,Bléry M,Steinle A

更新日期：2020-06-04 00:00:00

abstract：:β-glucan, the most abundant fungal cell wall polysaccharide, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study of this molecule has been motivated by its importance as a pathogen-associated molecular pattern upon fungal...

journal_title：Frontiers in immunology

authors： Camilli G,Tabouret G,Quintin J

更新日期：2018-04-16 00:00:00

abstract：:Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen...

journal_title：Frontiers in immunology

authors： Brendolan A,Caamaño JH

更新日期：2012-12-14 00:00:00

abstract：:The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways. Various membrane-bound and plasma regulatory proteins control the activation of the potentially deleterious complement system. Am...

journal_title：Frontiers in immunology

authors： Sánchez-Corral P,Pouw RB,López-Trascasa M,Józsi M

更新日期：2018-07-12 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

journal_title：Frontiers in immunology

authors： Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

更新日期：2018-06-11 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:A wide variety of biomaterials have been developed as both stabilizing structures for the injured bone and inducers of bone neoformation. They differ in chemical composition, shape, porosity, and mechanical properties. The most extensively employed and studied subset of bioceramics are calcium phosphate materials (CaP...

journal_title：Frontiers in immunology

authors： Humbert P,Brennan MÁ,Davison N,Rosset P,Trichet V,Blanchard F,Layrolle P

更新日期：2019-04-02 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：:The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural variation. We constructed two Tat-expression vectors encoding Tat protei...

journal_title：Frontiers in immunology

authors： Menon M,Budhwar R,Shukla RN,Bankar K,Vasudevan M,Ranga U

更新日期：2020-09-25 00:00:00

abstract：:Accumulation of dendritic cells (DCs) is a special characteristic of the decidual microenvironment. Decidua-infiltrated DCs show unique phenotypes and functions that promote the establishment of fetal-maternal tolerance. However, the regulatory mechanisms yet to be fully investigated. Decidual stromal cells (DSCs) are...

journal_title：Frontiers in immunology

authors： Shao Q,Liu X,Huang Y,Chen X,Wang H

更新日期：2020-10-27 00:00:00