Cyclic Peptide [R4W4] in Improving the Ability of First-Line Antibiotics to Inhibit Mycobacterium tuberculosis Inside in vitro Human Granulomas.

abstract：:NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I genes. In line with the function of several related NLR proteins in innate immune responses, there is, however, also ample evidence that NLRC5 contributes to innate and adaptive immune responses beyond the regulation of MHC cla...

journal_title：Frontiers in immunology

authors： Benkő S,Kovács EG,Hezel F,Kufer TA

更新日期：2017-02-17 00:00:00

abstract：:Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled gra...

journal_title：Frontiers in immunology

authors： Matsuda Y,Sarwal MM

更新日期：2016-10-21 00:00:00

abstract：:Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological ...

journal_title：Frontiers in immunology

authors： Luo Y,Meyer N,Jiao Q,Scheffel J,Zimmermann C,Metz M,Zenclussen A,Maurer M,Siebenhaar F

更新日期：2019-10-15 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airway. Its major symptoms are reversible breathing problems causing airway narrowing and obstruction. IL-19 is a member of the IL-10 family cytokines. We previously showed that IL-19 induces T-helper 2 (Th2) cytokines and that asthma patients had higher serum IL-19 leve...

journal_title：Frontiers in immunology

authors： Weng YH,Chen WY,Lin YL,Wang JY,Chang MS

更新日期：2019-04-30 00:00:00

abstract：:Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

journal_title：Frontiers in immunology

authors： Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

更新日期：2020-01-21 00:00:00

abstract：:Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of an IL-2 agonist in a...

journal_title：Frontiers in immunology

authors： Link CWM,Rau CN,Udoye CC,Ragab M,Korkmaz RÜ,Comdühr S,Clauder AK,Lindemann T,Frehse B,Hofmann K,Almeida LN,Laumonnier Y,Beidaq AE,Finkelman FD,Manz RA

更新日期：2020-12-11 00:00:00

abstract：:Genital herpes is a common sexually transmitted infection caused by herpes simplex virus type 2 (HSV-2). Genital herpes significantly enhances the acquisition and transmission of HIV-1 by creating a microenvironment that supports HIV infection in the host. Dendritic cells (DCs) represent one of the first innate cell t...

journal_title：Frontiers in immunology

authors： Crisci E,Svanberg C,Ellegård R,Khalid M,Hellblom J,Okuyama K,Bhattacharya P,Nyström S,Shankar EM,Eriksson K,Larsson M

更新日期：2019-12-06 00:00:00

abstract：:Influenza virus infection causes 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide annually. Although pneumonia is the most common complication associated with influenza, there are several reports demonstrating increased risk for cardiovascular diseases. Several clinical case reports, as well as...

journal_title：Frontiers in immunology

authors： Gopal R,Marinelli MA,Alcorn JF

更新日期：2020-10-22 00:00:00

abstract：:Among interferon (IFN) inducible antiviral factors both tripartite motif-containing protein 22 (TRIM22) and class II transactivator (CIITA) share the capacity of repressing human immunodeficiency virus type 1 (HIV-1) proviral transcription. TRIM22 is constitutively expressed in a subset of U937 cell clones poorly perm...

journal_title：Frontiers in immunology

authors： Forlani G,Tosi G,Turrini F,Poli G,Vicenzi E,Accolla RS

更新日期：2017-05-15 00:00:00

abstract：:Over the past two decades, heat shock proteins (HSPs) have been implicated in inflammatory responses and autoimmunity. HSPs were originally believed to maintain protein quality control in the cytosol. However, they also exist extracellularly and appear to act as inflammatory factors. Recently, a growing body of eviden...

journal_title：Frontiers in immunology

authors： Morito D,Nagata K

更新日期：2012-03-15 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:Cow's milk protein allergy (CMPA) is the most common allergy in the first year of life. Non-IgE mediated CMPA is characterized by digestive symptoms and tolerance development before the age of three. Gut microbiota composition in early life has been associated with food allergy. The ingestion of different foods/nutrie...

journal_title：Frontiers in immunology

authors： Guadamuro L,Diaz M,Jiménez S,Molinos-Norniella C,Pérez-Solis D,Rodríguez JM,Bousoño C,Gueimonde M,Margolles A,Delgado S,Díaz JJ

更新日期：2019-08-02 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:The host immune response to gastrointestinal (GI) infections, hypersensitivity reactions, or GI cancers comprises numerous pathways that elicit responses on different host cells. Some of these include (1) the stimulation of mast cells via their IgE receptor, (2) the production of antibodies leading to antibody-mediate...

journal_title：Frontiers in immunology

authors： El-Zaatari M,Kao JY

更新日期：2017-01-27 00:00:00

abstract：:Formation of pathological anti-FVIII antibodies, or "inhibitors," is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from the innate immune sys...

journal_title：Frontiers in immunology

authors： Karim AF,Soltis AR,Sukumar G,Königs C,Ewing NP,Dalgard CL,Wilkerson MD,Pratt KP

更新日期：2020-06-12 00:00:00

abstract：:Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody deficiency and identified five disease-associated variants in NFKB...

journal_title：Frontiers in immunology

authors： Schröder C,Sogkas G,Fliegauf M,Dörk T,Liu D,Hanitsch LG,Steiner S,Scheibenbogen C,Jacobs R,Grimbacher B,Schmidt RE,Atschekzei F

更新日期：2019-11-14 00:00:00

abstract：Background:CD1d restricted invariant natural killer T (iNKT) cells are important in the activation and regulation of immune responses. Limited information is available regarding the functional role of iNKT cells in the human immunodeficiency virus (HIV) disease progression. Methodology:α-GalCer stimulated iNKT cells w...

journal_title：Frontiers in immunology

authors： Singh D,Ghate M,Godbole S,Kulkarni S,Thakar M

更新日期：2018-05-24 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of "self" antigens able to...

journal_title：Frontiers in immunology

authors： Frasca D,Diaz A,Romero M,Garcia D,Jayram D,Thaller S,Del Carmen Piqueras M,Bhattacharya S,Blomberg BB

更新日期：2020-02-28 00:00:00

abstract：:Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

journal_title：Frontiers in immunology

authors： Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

更新日期：2020-06-17 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect obse...

journal_title：Frontiers in immunology

authors： Sharapova SO,Pashchenko OE,Bondarenko AV,Vakhlyarskaya SS,Prokofjeva T,Fedorova AS,Savchak I,Mareika Y,Valiev TT,Popa A,Tuzankina IA,Vlasova EV,Sakovich IS,Polyakova EA,Rumiantseva NV,Naumchik IV,Kulyova SA,Aleshkevich

更新日期：2021-01-08 00:00:00

abstract：:Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is largely dictated by environmental signals. Fully activated immunos...

journal_title：Frontiers in immunology

authors： Carenza C,Calcaterra F,Oriolo F,Di Vito C,Ubezio M,Della Porta MG,Mavilio D,Della Bella S

更新日期：2019-06-11 00:00:00

abstract：:The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of new antibiotics is notoriously costly and slow; therefore, alternative strategies are needed. Antimicrobial peptides (AMPs), the central effector molecules of the...

journal_title：Frontiers in immunology

authors： Geitani R,Moubareck CA,Xu Z,Karam Sarkis D,Touqui L

更新日期：2020-06-30 00:00:00

abstract：:Channel catfish farming dominates the aquaculture industry in the United States. However, epidemic outbreaks of motile Aeromonas septicemia (MAS), caused by virulent Aeromonas hydrophila (vAh), have become a prominent problem in the catfish industry. Although vaccination is an effective preventive method, there is no ...

journal_title：Frontiers in immunology

authors： Abdelhamed H,Banes M,Karsi A,Lawrence ML

更新日期：2019-07-16 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor-specific antibodie...

journal_title：Frontiers in immunology

authors： Dahdal S,Saison C,Valette M,Bachy E,Pallet N,Lina B,Koenig A,Monneret G,Defrance T,Morelon E,Thaunat O

更新日期：2019-02-05 00:00:00

abstract：:Mycobacteria propelled modulation of host responses is of considerable interest in the face of emerging drug resistance. Although it is known that Abl tyrosine kinases affect entry and persistence of mycobacteria, mechanisms that couple c-Abl to proximal signaling pathways during immunity are poorly understood. Loss-o...

journal_title：Frontiers in immunology

authors： Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN

更新日期：2018-02-01 00:00:00

abstract：:Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

journal_title：Frontiers in immunology

authors： Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

更新日期：2019-05-09 00:00:00