Abstract:
:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inactive precursor, the proIL-1β in 17KDa active IL-1β peptide, is controlled by caspase-1-dependent pathway, associated with inflammasomes. Other caspase-1 independent mechanisms mediated by proteases, especially as MMPs, have already been described. Methods: We evaluated IL-1β activation pathways in neutrophils and monocyte subsets from patients with different clinical forms of Chagas disease after T. cruzi antigen stimulation by multiparameter flow cytometry. Results: Our data demonstrated that Chagas patients with the indeterminate clinical form (IND) showed increased levels of IL-1β post-stimulation as well as increased expression of MMP-2, NLRP3, and CASP1, which are associated with the classical caspase-1-dependent pathway. Conversely, patients with the cardiac clinical form (CARD) showed increased IL-1β after stimulation associated with MMP-9 and alternative caspase-1-independent pathway. Conclusions: We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease. MMP-2 and MMP-9 gelatinases are associated with distinct disease outcomes and IL-1β production.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JASdoi
10.3389/fimmu.2019.00800subject
Has Abstractpub_date
2019-04-18 00:00:00pages
800issn
1664-3224journal_volume
10pub_type
杂志文章abstract::Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole...
journal_title:Frontiers in immunology
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.03016
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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abstract::Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...
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journal_title:Frontiers in immunology
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doi:10.3389/fimmu.2019.00404
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
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doi:10.3389/fimmu.2013.00249
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doi:10.3389/fimmu.2017.00322
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pub_type: 杂志文章
doi:10.3389/fimmu.2017.01620
更新日期:2017-11-23 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.01797
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abstract::Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively and qualitatively in the elderly. However, the function of human B-1 cells, which play critical anti-microbial and housekeeping roles...
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doi:10.3389/fimmu.2019.00483
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
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doi:10.3389/fimmu.2018.01350
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pub_type: 杂志文章
doi:10.3389/fimmu.2014.00294
更新日期:2014-06-19 00:00:00
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doi:10.3389/fimmu.2018.02142
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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