Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance.


:Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development of GVHD. Host-derived DCs are important to elicit allogeneic T cell responses, whereas certain donor-types of DCs derived from newly engrafted hematopoietic stem/progenitor cells (HSPCs) can amply this graft-vs.-host reaction. In contrast, some DCs also play non-redundant roles in mediating immune tolerance. They induce apoptotic deletion of host-reactive donor T cells while promoting expansion and function of regulatory T cells (Treg). Unfortunately, this tolerogenic effect of DCs is impaired during GVHD. Severe GVHD in patients subject to allo-HSCT is associated with significantly decreased number of circulating peripheral blood DCs during engraftment. Existing studies reveal that GVHD causes delayed reconstitution of donor DCs from engrafted HSPCs, impairs the antigen presentation function of newly generated DCs and reduces the capacity of DCs to regulate Treg. The present review will discuss the importance of DCs in alloimmunity and the mechanism underlying DC reconstitution after allo-HSCT.


Front Immunol


Frontiers in immunology


Yu H,Tian Y,Wang Y,Mineishi S,Zhang Y




Has Abstract


2019-02-01 00:00:00








  • Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells.

    abstract::The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

    更新日期:2020-12-23 00:00:00

  • PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis.

    abstract::Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1hi, tissue-resident memory populat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Shwetank,Frost EL,Mockus TE,Ren HM,Toprak M,Lauver MD,Netherby-Winslow CS,Jin G,Cosby JM,Evavold BD,Lukacher AE

    更新日期:2019-04-17 00:00:00

  • The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.

    abstract::Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Gonçalves-de-Albuquerque SDC,Pessoa-E-Silva R,Trajano-Silva LAM,de Goes TC,de Morais RCS,da C Oliveira CN,de Lorena VMB,de Paiva-Cavalcanti M

    更新日期:2017-10-30 00:00:00

  • Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.

    abstract::Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

    更新日期:2018-05-29 00:00:00

  • T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response.

    abstract::Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent immune responses is n...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Aragoneses-Fenoll L,Ojeda G,Montes-Casado M,Acosta-Ampudia Y,Dianzani U,Portolés P,Rojo JM

    更新日期:2018-02-27 00:00:00

  • Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation.

    abstract::Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Son S,Shim DW,Hwang I,Park JH,Yu JW

    更新日期:2019-05-16 00:00:00

  • Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation.

    abstract::Hyaluronan (HA), the major extracellular matrix component, is often anchored to CD44, a family of structurally/functionally important cell surface receptors. Recent results indicate that UV irradiation (UVR)-induced cutaneous squamous cell carcinomas (SCC) overexpress a variety of CD44 variant isoforms (CD44v), with d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Bourguignon LY,Bikle D

    更新日期:2015-05-13 00:00:00

  • Evaluating the Vaccine Potential of a Tetravalent Fusion Protein (rBmHAXT) Vaccine Antigen Against Lymphatic Filariasis in a Mouse Model.

    abstract::Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against thi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Chauhan N,Khatri V,Banerjee P,Kalyanasundaram R

    更新日期:2018-07-02 00:00:00

  • Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D.

    abstract::Bi-allelic null mutations affecting UNC13D, STXBP2, or STX11 result in defects of lymphocyte cytotoxic degranulation and commonly cause familial hemophagocytic lymphohistiocytosis (FHL) in early life. Patients with partial loss of function are increasingly being diagnosed after presenting with alternative features of ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gray PE,Shadur B,Russell S,Mitchell R,Buckley M,Gallagher K,Andrews I,Thia K,Trapani JA,Kirk EP,Voskoboinik I

    更新日期:2017-08-09 00:00:00

  • Innate Allorecognition and Memory in Transplantation.

    abstract::Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation an...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FG

    更新日期:2020-05-28 00:00:00

  • Monocyte HLA-DR Assessment by a Novel Point-of-Care Device Is Feasible for Early Identification of ICU Patients With Complicated Courses-A Proof-of-Principle Study.

    abstract::Background: Critically ill patients, especially following trauma or extensive surgery, experience a systemic immune response, consisting of a pro-inflammatory as well as a counterbalancing anti-inflammatory response. Pro-inflammation is necessary for the initiation of homeostatic control and wound healing of the organ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Tamulyte S,Kopplin J,Brenner T,Weigand MA,Uhle F

    更新日期:2019-03-12 00:00:00

  • Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma.

    abstract::Mouse allergy has become increasingly common, mainly affecting laboratory workers and inner-city households. To date, only one major allergen, namely Mus m 1, has been described. We sought to identify T cell targets in mouse allergic patients. PBMC from allergic donors were expanded with either murine urine or epithel...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schulten V,Westernberg L,Birrueta G,Sidney J,Paul S,Busse P,Peters B,Sette A

    更新日期:2018-02-13 00:00:00

  • Pathophysiology of GvHD and Other HSCT-Related Major Complications.

    abstract::For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve pa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ghimire S,Weber D,Mavin E,Wang XN,Dickinson AM,Holler E

    更新日期:2017-03-20 00:00:00

  • HO-1 and CD39: It Takes Two to Protect the Realm.

    abstract::Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment. Indeed, evolution has ensured that each cell is equipped with multiple overlapping families of genes that safeguard against pathogens, injury, st...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Lee GR,Shaefi S,Otterbein LE

    更新日期:2019-07-26 00:00:00

  • NETosis in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses. Neuroinflammation is a well-established fea...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Pietronigro EC,Della Bianca V,Zenaro E,Constantin G

    更新日期:2017-03-02 00:00:00

  • Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells.

    abstract::Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed after antigen clearance and a long-term resting phase accompanied ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Onodera A,Kokubo K,Nakayama T

    更新日期:2018-12-12 00:00:00

  • Cytokine-Based Generation of CD49a+Eomes-/+ Natural Killer Cell Subsets.

    abstract::Recent studies have identified CD49a+Eomes- and CD49a+Eomes+ subsets of tissue-resident NK (trNK) cells in different organs of the mouse. However, the characteristics of CD49a+Eomes-/+ NK cell development and the regulation of Eomes expression in NK cells remain unclear. Here, we established an in vitro cytokine-based...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ni X,Fu B,Zhang J,Sun R,Tian Z,Wei H

    更新日期:2018-09-25 00:00:00

  • Bacterial Lipopolysaccharides Suppress Erythroblastic Islands and Erythropoiesis in the Bone Marrow in an Extrinsic and G- CSF-, IL-1-, and TNF-Independent Manner.

    abstract::Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

    更新日期:2020-10-06 00:00:00

  • Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19).

    abstract::Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. Methods: ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Diao B,Wang C,Tan Y,Chen X,Liu Y,Ning L,Chen L,Li M,Liu Y,Wang G,Yuan Z,Feng Z,Zhang Y,Wu Y,Chen Y

    更新日期:2020-05-01 00:00:00

  • Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity.

    abstract::The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progressi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Terry S,Buart S,Chouaib S

    更新日期:2017-11-24 00:00:00

  • A Neutrophil-Driven Inflammatory Signature Characterizes the Blood Transcriptome Fingerprint of Psoriasis.

    abstract::Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

    更新日期:2020-11-24 00:00:00

  • Tolerogenic Role of Myeloid Suppressor Cells in Organ Transplantation.

    abstract::Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strateg...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ochando J,Conde P,Utrero-Rico A,Paz-Artal E

    更新日期:2019-03-06 00:00:00

  • Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis.

    abstract::Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an "alarmin" role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cell...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Li L,Zhu H,Zuo X

    更新日期:2018-11-15 00:00:00

  • Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.

    abstract::Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

    更新日期:2018-11-01 00:00:00

  • Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer's Disease Brain.

    abstract::Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechan...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhao Y,Cong L,Jaber V,Lukiw WJ

    更新日期:2017-09-04 00:00:00

  • Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.

    abstract::Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Liu R,Nikolajczyk BS

    更新日期:2019-07-17 00:00:00

  • Phenotype and Function of Activated Natural Killer Cells From Patients With Prostate Cancer: Patient-Dependent Responses to Priming and IL-2 Activation.

    abstract::Background: Although immunotherapy has emerged as the "next generation" of cancer treatments, it has not yet been shown to be successful in the treatment of patients with prostate cancer, for whom therapeutic options remain limited to radiotherapy and androgen (hormone) deprivation therapy. Previous studies have shown...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hood SP,Foulds GA,Imrie H,Reeder S,McArdle SEB,Khan M,Pockley AG

    更新日期:2019-01-25 00:00:00

  • Plasminflammation-An Emerging Pathway to Bradykinin Production.

    abstract::Plasminogen activation is essential for fibrinolysis-the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Maas C

    更新日期:2019-08-27 00:00:00

  • Dissection of the Human T-Cell Receptor γ Gene Repertoire in the Brain and Peripheral Blood Identifies Age- and Alzheimer's Disease-Associated Clonotype Profiles.

    abstract::The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TRGs in patients with AD a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Aliseychik M,Patrikeev A,Gusev F,Grigorenko A,Andreeva T,Biragyn A,Rogaev E

    更新日期:2020-01-29 00:00:00

  • Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy.

    abstract::A body of evidence suggests that food allergy (FA) has increased in prevalence over the past few decades. Novel findings support the hypothesis that some commensal bacteria and particularly microbial metabolites might contribute to development of oral tolerance and prevention from FA. Recently, beneficial effects of s...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Luu M,Monning H,Visekruna A

    更新日期:2020-06-16 00:00:00