Abstract:
:Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-delta (γδ) T cells, can also contribute to protective immunity, but their effect is not actuated during the natural course of infection. This review serves to consolidate and discuss the multifaceted roles of these T cell subsets during acute and chronic phases of CHIKV infection, and highlight gaps in the current literature. Importantly, the unique characteristics of skin-resident memory T cells are outlined to propose novel prophylactic strategies that utilize their properties to provide adequate, lasting protection.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Poh CM,Chan YH,Ng LFPdoi
10.3389/fimmu.2020.00287subject
Has Abstractpub_date
2020-02-21 00:00:00pages
287issn
1664-3224journal_volume
11pub_type
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2016.00167
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.00226
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journal_title:Frontiers in immunology
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.02512
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.00348
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pub_type: 杂志文章
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更新日期:2013-06-04 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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更新日期:2012-02-27 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.00980
更新日期:2019-05-03 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.575451
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2020.596772
更新日期:2020-12-11 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.00869
更新日期:2018-04-30 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2015.00543
更新日期:2015-11-02 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2015.00620
更新日期:2016-01-06 00:00:00
abstract::[This corrects the article DOI: 10.3389/fimmu.2020.562282.]. ...
journal_title:Frontiers in immunology
pub_type: 已发布勘误
doi:10.3389/fimmu.2020.625157
更新日期:2020-12-16 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 已发布勘误
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journal_title:Frontiers in immunology
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doi:10.3389/fimmu.2012.00205
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journal_title:Frontiers in immunology
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type:
doi:10.3389/fimmu.2020.00046
更新日期:2020-02-12 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2020.00235
更新日期:2020-02-21 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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