Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity.

abstract：:Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously,...

journal_title：Frontiers in immunology

authors： Youssef EG,Zhang L,Alkhazraji S,Gebremariam T,Singh S,Yount NY,Yeaman MR,Uppuluri P,Ibrahim AS

更新日期：2020-02-18 00:00:00

abstract：:B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required ...

journal_title：Frontiers in immunology

authors： Brzostek J,Gascoigne NR,Rybakin V

更新日期：2016-02-04 00:00:00

abstract：:The size and composition of the T lymphocyte compartment is subject to strict homeostatic regulation and is remarkably stable throughout life in spite of variable dynamics in cell production and death during T cell development and immune responses. Homeostasis is achieved by careful orchestration of lymphocyte surviva...

journal_title：Frontiers in immunology

authors： Hapuarachchi T,Lewis J,Callard RE

更新日期：2013-11-11 00:00:00

abstract：:Novel adjuvant technologies have a key role in the development of next-generation vaccines, due to their capacity to modulate the duration, strength and quality of the immune response. The AS01 adjuvant is used in the malaria vaccine RTS,S/AS01 and in the licensed herpes-zoster vaccine (Shingrix) where the vaccine has...

journal_title：Frontiers in immunology

authors： Buckley PR,Alden K,Coccia M,Chalon A,Collignon C,Temmerman ST,Didierlaurent AM,van der Most R,Timmis J,Andersen CA,Coles MC

更新日期：2019-09-12 00:00:00

abstract：:Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Upon binding to CD38-expressing MM cells, isatuximab is thought to induce tumor cell killing via fragment crystallizable (...

journal_title：Frontiers in immunology

authors： Zhu C,Song Z,Wang A,Srinivasan S,Yang G,Greco R,Theilhaber J,Shehu E,Wu L,Yang ZY,Passe-Coutrin W,Fournier A,Tai YT,Anderson KC,Wiederschain D,Bahjat K,Adrián FJ,Chiron M

更新日期：2020-08-14 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes. In BP, 80 to 90% of autoantibodies target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. Recently, the administrat...

journal_title：Frontiers in immunology

authors： Mai Y,Nishie W,Izumi K,Shimizu H

更新日期：2019-05-29 00:00:00

abstract：:Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire. In this paper, we enrich these...

journal_title：Frontiers in immunology

authors： Krawczyk K,Kelm S,Kovaltsuk A,Galson JD,Kelly D,Trück J,Regep C,Leem J,Wong WK,Nowak J,Snowden J,Wright M,Starkie L,Scott-Tucker A,Shi J,Deane CM

更新日期：2018-07-23 00:00:00

abstract：:The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+ cell population to ...

journal_title：Frontiers in immunology

authors： Wang X,Laan M,Bichele R,Kisand K,Scott HS,Peterson P

更新日期：2012-03-01 00:00:00

abstract：:Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Cytokines are known to play vital role as a peacekeeper during inflammatory and other immunocompromised conditions such as leprosy. This study has tried to bridge the gap of information on cytokine gene polymorphisms and its potential role in the p...

journal_title：Frontiers in immunology

authors： Tarique M,Naz H,Saini C,Suhail M,Shankar H,Khanna N,Sharma A

更新日期：2020-08-06 00:00:00

abstract：:Soluble factors are an essential means of communication between cells and their environment. However, many molecules readily interact with extracellular matrix components, giving rise to multiple modes of diffusion. The molecular quantification of diffusion in situ is thus a challenging imaging frontier, requiring ver...

journal_title：Frontiers in immunology

authors： Miller H,Cosgrove J,Wollman AJM,Taylor E,Zhou Z,O'Toole PJ,Coles MC,Leake MC

更新日期：2018-05-22 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:Effector T cells exit the inflamed vasculature into an environment shaped by tissue-specific structural configurations and inflammation-imposed extrinsic modifications. Once within interstitial spaces of non-lymphoid tissues, T cells migrate in an apparent random, non-directional, fashion. Efficient T cell scanning of...

journal_title：Frontiers in immunology

authors： Gaylo A,Schrock DC,Fernandes NR,Fowell DJ

更新日期：2016-10-14 00:00:00

abstract：:Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miR...

journal_title：Frontiers in immunology

authors： Croston TL,Lemons AR,Beezhold DH,Green BJ

更新日期：2018-02-07 00:00:00

abstract：:In the last two decades, extracellular vesicles (EVs) have aroused wide interest among researchers in basic and clinical research. EVs, small membrane vesicles are released by almost all kinds of cells into the extracellular environment. According to many recent studies, EVs participate in immunomodulation and play an...

journal_title：Frontiers in immunology

authors： Zhang B,Zhao M,Lu Q

更新日期：2021-01-14 00:00:00

abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...

journal_title：Frontiers in immunology

authors： Serrano-Coll H,Ospina JP,Salazar-Peláez L,Cardona-Castro N

更新日期：2020-03-19 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avo...

journal_title：Frontiers in immunology

authors： Chaput C,Sander LE,Suttorp N,Opitz B

更新日期：2013-11-21 00:00:00

abstract：:Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human populations. In contrast, innate-like T cells quickly respond to patho...

journal_title：Frontiers in immunology

authors： Huang S

更新日期：2016-12-21 00:00:00

abstract：:Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with H...

journal_title：Frontiers in immunology

authors： Chen L,Wang C,Luo J,Su W,Li M,Zhao N,Lyu W,Attaran H,He Y,Ding H,He H

更新日期：2017-12-12 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland, or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients' age over 18 mont...

journal_title：Frontiers in immunology

authors： Bottino C,Dondero A,Bellora F,Moretta L,Locatelli F,Pistoia V,Moretta A,Castriconi R

更新日期：2014-02-12 00:00:00

abstract：:The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especially in laboratory mice since they are used so heavily to model im...

journal_title：Frontiers in immunology

authors： Kokolus KM,Spangler HM,Povinelli BJ,Farren MR,Lee KP,Repasky EA

更新日期：2014-02-10 00:00:00

abstract：:Sjögren's syndrome (SS) is a systemic autoimmune disease mainly characterized by inflammatory involvement of exocrine gland. Atherosclerosis is a complex process leading to plaque formation in arterial wall with subsequent cardiovascular (CV) events. Recently, numerous studies demonstrated that SS patients bear an inc...

journal_title：Frontiers in immunology

authors： Bartoloni E,Alunno A,Cafaro G,Valentini V,Bistoni O,Bonifacio AF,Gerli R

更新日期：2019-04-17 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the...

journal_title：Frontiers in immunology

authors： Pelosi A,Alicata C,Tumino N,Ingegnere T,Loiacono F,Mingari MC,Moretta L,Vacca P

更新日期：2020-02-06 00:00:00

abstract：:The emergence and continuous development of immune checkpoint inhibitors (ICIs) therapy brings a revolution in cancer therapy history, but the major hurdle associated with their usage is the concomitant ICIs-related toxicities that present a challenge for oncologists. The toxicities may involve non-specific symptoms o...

journal_title：Frontiers in immunology

authors： Xu Y,Fu Y,Zhu B,Wang J,Zhang B

更新日期：2020-10-06 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a common and devastating autoimmune disease, characterized by a dysregulated adaptive immune response against intracellular antigens, which involves both autoreactive T and B cells. In SLE, mainly intracellular autoantigens generate autoantibodies and these assemble into immune co...

journal_title：Frontiers in immunology

authors： Ugarte-Berzal E,Boon L,Martens E,Rybakin V,Blockmans D,Vandooren J,Proost P,Opdenakker G

更新日期：2019-03-22 00:00:00

abstract：:Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells being more related to inflammation and autoimmunity while M2-polariz...

journal_title：Frontiers in immunology

authors： Montes-Cobos E,Schweingruber N,Li X,Fischer HJ,Reichardt HM,Lühder F

更新日期：2017-10-13 00:00:00

abstract：:Background: CXCL13 is preferentially secreted by Follicular Helper T cells (TFH) to attract B cells to germinal centers. Plasma levels of CXCL13 have been reported to be elevated during chronic HIV-infection, however there is limited data on such elevation during early phases of infection and on the effect of ART. Mor...

journal_title：Frontiers in immunology

authors： Mehraj V,Ramendra R,Isnard S,Dupuy FP,Lebouché B,Costiniuk C,Thomas R,Szabo J,Baril JG,Trottier B,Coté P,LeBlanc R,Durand M,Chartrand-Lefebvre C,Kema I,Zhang Y,Finkelman M,Tremblay C,Routy JP

更新日期：2019-02-21 00:00:00