Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires.

Abstract:

:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral immune system, or induce memory B cells with a diminished ability to differentiate into new plasma cells. This leaves the host vulnerable to chronic or recurrent infections. Single cell approaches coupled with next generation antibody gene sequencing facilitate a detailed analysis of the pathogen-specific memory B cell repertoire. Monoclonal antibodies that are generated from antibody gene sequences allow a functional analysis of the repertoire. This review discusses what has been learned thus far from analysis of diverse pathogen-specific memory B cell compartments and describes major differences in their repertoires. Such information may illuminate ways to advance the goal of improving vaccine and therapeutic antibody design.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

doi

10.3389/fimmu.2018.03064

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

3064

issn

1664-3224

journal_volume

9

pub_type

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