B Cell Functions Can Be Modulated by Antimicrobial Peptides in Rainbow Trout Oncorhynchus mykiss: Novel Insights into the Innate Nature of B Cells in Fish.

abstract：:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inacti...

journal_title：Frontiers in immunology

authors： Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JAS

更新日期：2019-04-18 00:00:00

abstract：:The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophag...

journal_title：Frontiers in immunology

authors： Jacquin E,Apetoh L

更新日期：2018-05-09 00:00:00

abstract：:HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at ...

journal_title：Frontiers in immunology

authors： Duquesnoy RJ

更新日期：2016-11-28 00:00:00

abstract：:Acinetobacter baumannii (A. baumannii) is becoming a common global concern due to the emergence of multi-drug or pan-drug resistant strains. Confronting the issue of antimicrobial resistance by developing vaccines against the resistant pathogen is becoming a common strategy. In this study, different methods for prepar...

journal_title：Frontiers in immunology

authors： Li S,Chen DQ,Ji L,Sun S,Jin Z,Jin ZL,Sun HW,Zeng H,Zhang WJ,Lu DS,Luo P,Zhao AN,Luo J,Zou QM,Li HB

更新日期：2020-06-23 00:00:00

abstract：:Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (RLRs) play an important role as sentinels to thwart ...

journal_title：Frontiers in immunology

authors： Yong HY,Luo D

更新日期：2018-06-20 00:00:00

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by activating innate se...

journal_title：Frontiers in immunology

authors： Nascimento CR,Andrade D,Carvalho-Pinto CE,Serra RR,Vellasco L,Brasil G,Ramos-Junior ES,da Mota JB,Almeida LN,Andrade MV,Correia Soeiro MN,Juliano L,Alvarenga PH,Oliveira AC,Sicuro FL,de Carvalho ACC,Svensjö E,Scharfstei

更新日期：2017-08-02 00:00:00

abstract：:Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isola...

journal_title：Frontiers in immunology

authors： Eggenhofer E,Benseler V,Kroemer A,Popp FC,Geissler EK,Schlitt HJ,Baan CC,Dahlke MH,Hoogduijn MJ

更新日期：2012-09-26 00:00:00

abstract：:The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies. So far only two alleles, the HLA-B*2706 in Asia and the HLA-B*2709 in Sardinia, have not been f...

journal_title：Frontiers in immunology

authors： Paladini F,Fiorillo MT,Tedeschi V,Cauli A,Mathieu A,Sorrentino R

更新日期：2019-01-25 00:00:00

abstract：:Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

journal_title：Frontiers in immunology

authors： Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

更新日期：2020-10-23 00:00:00

abstract：:Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

journal_title：Frontiers in immunology

authors： Korn T,Muschaweckh A

更新日期：2019-11-14 00:00:00

abstract：:Microvesicles (MVs) are membrane particles of 200-500 nm released by all cell types constitutively. MVs of myeloid origin are found increased in the cerebrospinal fluid (CSF) of patients suffering from neuroinflammatory disorders, although the factors triggering their production have never been defined. Here, we repor...

journal_title：Frontiers in immunology

authors： Colombo F,Bastoni M,Nigro A,Podini P,Finardi A,Casella G,Ramesh M,Farina C,Verderio C,Furlan R

更新日期：2018-02-07 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of autoimmune disorders, transplant-allograft rejection, virus-mediated tis...

journal_title：Frontiers in immunology

authors： Schmidt C,Berger T,Groettrup M,Basler M

更新日期：2018-10-26 00:00:00

abstract：:One of the major contributions to protective immunity to influenza viruses that is provided by virus-specific CD4 T cells is delivery of effector function to the infected lung. However, there is little known about the selection and breadth of viral epitope-specific CD4 T cells that home to the lung after their initial...

journal_title：Frontiers in immunology

authors： Richards KA,DiPiazza AT,Rattan A,Knowlden ZAG,Yang H,Sant AJ

更新日期：2018-04-06 00:00:00

abstract：:Cell migration is indispensable for various biological processes including angiogenesis, wound healing, and immunity. In general, there are two different migration modes described, the mesenchymal migration mode and the amoeboid migration mode. Neutrophils rapidly migrate toward the sites of injury, infection, and inf...

journal_title：Frontiers in immunology

authors： Salvermoser M,Begandt D,Alon R,Walzog B

更新日期：2018-11-16 00:00:00

abstract：:Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a d...

journal_title：Frontiers in immunology

authors： Whittaker E,Goldblatt D,McIntyre P,Levy O

更新日期：2018-04-04 00:00:00

abstract：:Chemokine biology is mediated by more complex interactions than simple monomolecular ligand-receptor interactions, as chemokines can form higher order quaternary structures, which can also be formed after binding to glycosaminoglycans (GAGs) on endothelial cells, and their receptors are found as dimers and/or oligomer...

journal_title：Frontiers in immunology

authors： Proudfoot AE,Uguccioni M

更新日期：2016-05-19 00:00:00

abstract：:One of the most significant challenges of cell biology is to understand how each type of cell copes with its specific workload without suffering damage. Among the most intriguing questions concerns intestinal epithelial cells in mammals; these cells act as a barrier between the internally protected region and the exte...

journal_title：Frontiers in immunology

authors： Randall-Demllo S,Chieppa M,Eri R

更新日期：2013-09-30 00:00:00

abstract：:Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

journal_title：Frontiers in immunology

authors： Griffin DO,Rothstein TL

更新日期：2012-05-25 00:00:00

abstract：:Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the Royal-Free-Hospital (RFH) London CVID cohort, including symptoms,...

journal_title：Frontiers in immunology

authors： van Schewick CM,Nöltner C,Abel S,Burns SO,Workman S,Symes A,Guzman D,Proietti M,Bulashevska A,Moreira F,Soetedjo V,Lowe DM,Grimbacher B

更新日期：2020-07-31 00:00:00

abstract：:Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to unravel NK cell funct...

journal_title：Frontiers in immunology

authors： Pende D,Falco M,Vitale M,Cantoni C,Vitale C,Munari E,Bertaina A,Moretta F,Del Zotto G,Pietra G,Mingari MC,Locatelli F,Moretta L

更新日期：2019-05-28 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Formation of pathological anti-FVIII antibodies, or "inhibitors," is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from the innate immune sys...

journal_title：Frontiers in immunology

authors： Karim AF,Soltis AR,Sukumar G,Königs C,Ewing NP,Dalgard CL,Wilkerson MD,Pratt KP

更新日期：2020-06-12 00:00:00

abstract：:Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...

journal_title：Frontiers in immunology

authors： Li Y,Zheng JY,Liu JQ,Yang J,Liu Y,Wang C,Ma XN,Liu BL,Xin GZ,Liu LF

更新日期：2016-12-07 00:00:00

abstract：:The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequ...

journal_title：Frontiers in immunology

authors： Toor JS,Rao AA,McShan AC,Yarmarkovich M,Nerli S,Yamaguchi K,Madejska AA,Nguyen S,Tripathi S,Maris JM,Salama SR,Haussler D,Sgourakis NG

更新日期：2018-01-30 00:00:00

abstract：:Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechan...

journal_title：Frontiers in immunology

authors： Zhao Y,Cong L,Jaber V,Lukiw WJ

更新日期：2017-09-04 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：:The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight ...

journal_title：Frontiers in immunology

authors： Pednekar L,Pathan AA,Paudyal B,Tsolaki AG,Kaur A,Abozaid SM,Kouser L,Khan HA,Peerschke EI,Shamji MH,Stenbeck G,Ghebrehiwet B,Kishore U

更新日期：2016-12-13 00:00:00