Characterization and functional properties of gastric tissue-resident memory T cells from children, adults, and the elderly.

abstract：:Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matr...

journal_title：Frontiers in immunology

authors： Mozos I,Malainer C,Horbańczuk J,Gug C,Stoian D,Luca CT,Atanasov AG

更新日期：2017-08-31 00:00:00

abstract：:Natural antibodies (NAbs) are pre-existing antibodies with germline origin that arise in the absence of previous exposure to foreign antigens. NAbs are produced by B-1 lymphocytes and are primarily of the IgM isotype. There is accumulating evidence that - in addition to their role in antimicrobial host defense - NAbs ...

journal_title：Frontiers in immunology

authors： Tsiantoulas D,Gruber S,Binder CJ

更新日期：2013-01-09 00:00:00

abstract：:Microparticles (MPs) are vesicles derived from the plasma membrane of different cells, are considered a source of circulating autoantigens, and can form immune complexes (MPs-ICs). The number of MPs and MPs-ICs increases in patients with systemic lupus erythematosus (SLE). MPs activate myeloid cells by inducing IL-6 a...

journal_title：Frontiers in immunology

authors： Burbano C,Villar-Vesga J,Orejuela J,Muñoz C,Vanegas A,Vásquez G,Rojas M,Castaño D

更新日期：2018-03-01 00:00:00

abstract：:Tumor necrosis factor-α inhibitors (TNFis) have revolutionized the management of rheumatoid arthritis (RA), however despite considerable progress, only a small proportion of patients maintain long-term clinical response. Selection of, and switching between, biologics is mainly empirical, experiential, and not evidence...

journal_title：Frontiers in immunology

authors： Mehta P,Manson JJ

更新日期：2020-04-07 00:00:00

abstract：Background:The role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via activation of the complement system or as direct opsonins. As recent ...

journal_title：Frontiers in immunology

authors： Vogt S,Trendelenburg M,Tamm M,Stolz D,Hostettler KE,Osthoff M

更新日期：2020-09-23 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00

abstract：:Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history...

journal_title：Frontiers in immunology

authors： Comberiati P,Costagliola G,Carli N,Legitimo A,D'Elios S,Consolini R,Peroni DG

更新日期：2019-07-17 00:00:00

abstract：:Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules is tightly controlled through the balance of a large repertoire of inhibitory and activating receptors...

journal_title：Frontiers in immunology

authors： Pfefferle A,Jacobs B,Haroun-Izquierdo A,Kveberg L,Sohlberg E,Malmberg KJ

更新日期：2020-05-12 00:00:00

abstract：:Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear receptor (NR) family of transcription factors have been reported to aff...

journal_title：Frontiers in immunology

authors： Tel-Karthaus N,Kers-Rebel ED,Looman MW,Ichinose H,de Vries CJ,Ansems M

更新日期：2018-08-03 00:00:00

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

journal_title：Frontiers in immunology

authors： Hack SP,Zhu AX,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that ...

journal_title：Frontiers in immunology

authors： Mesman AW,Geijtenbeek TB

更新日期：2012-03-26 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease. Complement proteins, regulators, and receptors are widely expressed throughout the CNS and, in many ...

journal_title：Frontiers in immunology

authors： Carpanini SM,Torvell M,Morgan BP

更新日期：2019-03-04 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs, we investigated whether DKK3 contributes to the immune suppre...

journal_title：Frontiers in immunology

authors： Lu KH,Tounsi A,Shridhar N,Küblbeck G,Klevenz A,Prokosch S,Bald T,Tüting T,Arnold B

更新日期：2015-12-24 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively and qualitatively in the elderly. However, the function of human B-1 cells, which play critical anti-microbial and housekeeping roles...

journal_title：Frontiers in immunology

authors： Rodriguez-Zhurbenko N,Quach TD,Hopkins TJ,Rothstein TL,Hernandez AM

更新日期：2019-03-19 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

journal_title：Frontiers in immunology

authors： Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

更新日期：2019-07-31 00:00:00

abstract：:Ectodermal dysplasias (ED) are uncommon genetic disorders resulting in abnormalities in ectodermally derived structures. Many ED-associated genes have been described, of which ectodysplasin-A (EDA) is one of the more common. The NF-κB essential modulator (NEMO encoded by the IKBKG gene) is unique in that mutations res...

journal_title：Frontiers in immunology

authors： Keller MD,Petersen M,Ong P,Church J,Risma K,Burham J,Jain A,Stiehm ER,Hanson EP,Uzel G,Deardorff MA,Orange JS

更新日期：2011-11-08 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes. In BP, 80 to 90% of autoantibodies target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. Recently, the administrat...

journal_title：Frontiers in immunology

authors： Mai Y,Nishie W,Izumi K,Shimizu H

更新日期：2019-05-29 00:00:00

abstract：:Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to fight against pathogen infection and tumors. Because of their abilit...

journal_title：Frontiers in immunology

authors： Takami M,Ihara F,Motohashi S

更新日期：2018-09-07 00:00:00

abstract：:Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15-40% of melanoma patients and resistance is associated with defects in antigen presentation and interferon signa...

journal_title：Frontiers in immunology

authors： Alavi S,Stewart AJ,Kefford RF,Lim SY,Shklovskaya E,Rizos H

更新日期：2018-06-21 00:00:00

abstract：:The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TRGs in patients with AD a...

journal_title：Frontiers in immunology

authors： Aliseychik M,Patrikeev A,Gusev F,Grigorenko A,Andreeva T,Biragyn A,Rogaev E

更新日期：2020-01-29 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is highly effective in the treatment of B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoma, providing alternative therapeutic options for patients who failed to respond to conventional treatment or relapse. Moreover, it can bridge other therapeutic strategies an...

journal_title：Frontiers in immunology

authors： Xu X,Sun Q,Liang X,Chen Z,Zhang X,Zhou X,Li M,Tu H,Liu Y,Tu S,Li Y

更新日期：2019-11-12 00:00:00

abstract：:CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyte glycoprotein pept...

journal_title：Frontiers in immunology

authors： Dagkonaki A,Avloniti M,Evangelidou M,Papazian I,Kanistras I,Tseveleki V,Lampros F,Tselios T,Jensen LT,Möbius W,Ruhwedel T,Androutsou ME,Matsoukas J,Anagnostouli M,Lassmann H,Probert L

更新日期：2020-11-19 00:00:00