Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases.

Abstract:

:Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Mozos I,Malainer C,Horbańczuk J,Gug C,Stoian D,Luca CT,Atanasov AG

doi

10.3389/fimmu.2017.01058

subject

Has Abstract

pub_date

2017-08-31 00:00:00

pages

1058

issn

1664-3224

journal_volume

8

pub_type

杂志文章,评审
  • Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.

    abstract::TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01243

    authors: Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

    更新日期:2017-10-03 00:00:00

  • Excess of Mortality in Adults and Elderly and Circulation of Subtypes of Influenza Virus in Southern Brazil.

    abstract:Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01903

    authors: Freitas ARR,Donalisio MR

    更新日期:2018-01-08 00:00:00

  • Paired Rheumatoid Arthritis Synovial Biopsies From Small and Large Joints Show Similar Global Transcriptomic Patterns With Enrichment of Private Specificity TCRB and TCR Signaling Pathways.

    abstract:Objectives:We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level. Methods:Synovial biopsies were performed simultaneously in one small and one large joint per patient using need...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.593083

    authors: Triaille C,Vansteenkiste L,Constant M,Ambroise J,Méric de Bellefon L,Nzeusseu Toukap A,Sokolova T,Galant C,Coulie P,Carrasco J,Durez P,Lauwerys BR

    更新日期:2020-11-23 00:00:00

  • Ataxia Telangiectasia Diagnosed on Newborn Screening-Case Cohort of 5 Years' Experience.

    abstract::Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase. The syndrome encompasses combined immunodeficiency and various degrees of neurological a...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章

    doi:10.3389/fimmu.2019.02940

    authors: Mandola AB,Reid B,Sirror R,Brager R,Dent P,Chakroborty P,Bulman DE,Roifman CM

    更新日期:2019-12-20 00:00:00

  • Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments.

    abstract::Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.02634

    authors: Korn T,Muschaweckh A

    更新日期:2019-11-14 00:00:00

  • Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients.

    abstract::Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2016.00560

    authors: Toor SM,Syed Khaja AS,El Salhat H,Bekdache O,Kanbar J,Jaloudi M,Elkord E

    更新日期:2016-12-08 00:00:00

  • Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.

    abstract::Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.03068

    authors: Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

    更新日期:2020-01-14 00:00:00

  • Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?

    abstract::The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progression toward MS. A connection between HERVs and MS is also supported b...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章

    doi:10.3389/fimmu.2018.03092

    authors: Morandi E,Tanasescu R,Tarlinton RE,Constantin-Teodosiu D,Gran B

    更新日期:2019-01-22 00:00:00

  • Emerging Mechanisms of Insulin-Mediated Antiviral Immunity in Drosophila melanogaster.

    abstract::Arboviruses (arthropod-borne viruses), such as Zika (ZIKV), West Nile (WNV), and dengue (DENV) virus, include some of the most significant global health risks to human populations. The steady increase in the number of cases is of great concern due to the debilitating diseases associated with each viral infection. Beca...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.02973

    authors: Trammell CE,Goodman AG

    更新日期:2019-12-20 00:00:00

  • Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells.

    abstract::Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. The composition of the T cell receptor (TCR) repertoire underlying this response remains poorly characterised, especially within African populations in which CMV is endemic ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02539

    authors: Attaf M,Malik A,Severinsen MC,Roider J,Ogongo P,Buus S,Ndung'u T,Leslie A,Kløverpris HN,Matthews PC,Sewell AK,Goulder P

    更新日期:2018-11-14 00:00:00

  • IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?

    abstract::Approximately 10% of individuals latently infected with Mycobacterium tuberculosis (Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial for containing latent TB infection, the full array of host factors conferring protective immunity ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2018.02209

    authors: Ronacher K,Sinha R,Cestari M

    更新日期:2018-09-25 00:00:00

  • Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome.

    abstract::Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede a diagnosis of multiple sclerosis (MS). Therefore, studying individuals with CIS may lead to breakthroughs in understanding the development and pathogenesis of MS. In this study, serum levels of immunoglobulin (Ig)G, IgA, I...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01590

    authors: Trend S,Jones AP,Cha L,Byrne SN,Geldenhuys S,Fabis-Pedrini MJ,Carroll WM,Cole JM,Booth DR,Lucas RM,Kermode AG,French MA,Hart PH

    更新日期:2018-07-13 00:00:00

  • Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis.

    abstract::Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of autoimmune disorders, transplant-allograft rejection, virus-mediated tis...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02386

    authors: Schmidt C,Berger T,Groettrup M,Basler M

    更新日期:2018-10-26 00:00:00

  • Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis.

    abstract::Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-c...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00383

    authors: Sahasrabudhe NM,Beukema M,Tian L,Troost B,Scholte J,Bruininx E,Bruggeman G,van den Berg M,Scheurink A,Schols HA,Faas MM,de Vos P

    更新日期:2018-03-01 00:00:00

  • The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins.

    abstract::Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01690

    authors: van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

    更新日期:2017-11-30 00:00:00

  • New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness.

    abstract::Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently treated with trastuzumab (Herceptin) and bevacizumab (Avastin), res...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01804

    authors: Corraliza-Gorjón I,Somovilla-Crespo B,Santamaria S,Garcia-Sanz JA,Kremer L

    更新日期:2017-12-21 00:00:00

  • Hyperprogressive Disease in Anorectal Melanoma Treated by PD-1 Inhibitors.

    abstract::The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00797

    authors: Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

    更新日期:2018-04-19 00:00:00

  • Interferon Signaling Is Frequently Downregulated in Melanoma.

    abstract::Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15-40% of melanoma patients and resistance is associated with defects in antigen presentation and interferon signa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01414

    authors: Alavi S,Stewart AJ,Kefford RF,Lim SY,Shklovskaya E,Rizos H

    更新日期:2018-06-21 00:00:00

  • Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential.

    abstract::Protein kinase C isoform θ (PKCθ) is a key modulator of TCR signaling and mediates activation of NF-κB, NF-AT, and AP-1 transcription factors. Although in vitro studies of PKCθ(-/-) T cells have shown impaired activation responses, in vivo studies indicate that PKCθ requirement is not universal. While PKCθ is importan...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2012.00259

    authors: Bronk CC,Yu XZ,Beg AA

    更新日期:2012-08-14 00:00:00

  • Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease.

    abstract::Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02784

    authors: Thompson KK,Nissen JC,Pretory A,Tsirka SE

    更新日期:2018-11-28 00:00:00

  • Extensive Alternative Splicing of KIR Transcripts.

    abstract::The killer-cell Ig-like receptors (KIR) form a multigene entity involved in modulating immune responses through interactions with MHC class I molecules. The complexity of the KIR cluster is reflected by, for instance, abundant levels of allelic polymorphism, gene copy number variation, and stochastic expression profil...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02846

    authors: Bruijnesteijn J,van der Wiel MKH,de Groot N,Otting N,de Vos-Rouweler AJM,Lardy NM,de Groot NG,Bontrop RE

    更新日期:2018-12-04 00:00:00

  • Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation.

    abstract::Overwhelming infection causes significant morbidity and mortality among patients treated with bone marrow transplantation (BMT) for primary immune deficiencies, syndromes of bone marrow failure, or cancer. The polymorphonuclear leukocyte (PMN; neutrophil) is the first responder to microbial invasion and acts within th...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2016.00250

    authors: Glenn JW,Cody MJ,McManus MP,Pulsipher MA,Schiffman JD,Yost CC

    更新日期:2016-06-27 00:00:00

  • The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design.

    abstract::The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.00278

    authors: Fleri W,Paul S,Dhanda SK,Mahajan S,Xu X,Peters B,Sette A

    更新日期:2017-03-14 00:00:00

  • Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.

    abstract::Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2013.00074

    authors: Harvie M,Camberis M,Le Gros G

    更新日期:2013-03-20 00:00:00

  • Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia.

    abstract::Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01817

    authors: Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

    更新日期:2018-08-06 00:00:00

  • DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway.

    abstract::DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear. Hence, th...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00925

    authors: Zhang Y,Han Y,Zhao Y,Lv Y,Hu Y,Tan Y,Bi X,Yu B,Kou J

    更新日期:2017-08-14 00:00:00

  • Association of Clinical Phenotypes in Haploinsufficiency A20 (HA20) With Disrupted Domains of A20.

    abstract::Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.574992

    authors: Chen Y,Ye Z,Chen L,Qin T,Seidler U,Tian D,Xiao F

    更新日期:2020-09-23 00:00:00

  • A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease.

    abstract:Background:Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or IL18 polymorphism p...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.521409

    authors: Gomes Dos Santos A,Watanabe EH,Ferreira DT,Oliveira J,Nakanishi ÉS,Oliveira CS,Bocchi E,Novaes CTG,Cruz F,Carvalho NB,Sato PK,Yamashiro-Kanashiro EH,Pontillo A,de Freitas VLT,Onuchic LF,Shikanai-Yasuda MA

    更新日期:2020-10-22 00:00:00

  • Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo.

    abstract::Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used in vitro macrophage...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,meta分析

    doi:10.3389/fimmu.2019.02887

    authors: Chen HJ,Li Yim AYF,Griffith GR,de Jonge WJ,Mannens MMAM,Ferrero E,Henneman P,de Winther MPJ

    更新日期:2019-12-11 00:00:00

  • HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine.

    abstract::Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mong...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.3389/fimmu.2019.00428

    authors: Yao Y,Yang H,Shi L,Liu S,Li C,Chen J,Zhou Z,Sun M,Shi L

    更新日期:2019-03-08 00:00:00