Role of Fused Mycobacterium tuberculosis Immunogens and Adjuvants in Modern Tuberculosis Vaccines.

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictl...

journal_title：Frontiers in immunology

authors： Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

更新日期：2016-06-24 00:00:00

abstract：:pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how...

journal_title：Frontiers in immunology

authors： Naffah de Souza C,Breda LCD,Khan MA,de Almeida SR,Câmara NOS,Sweezey N,Palaniyar N

更新日期：2018-01-09 00:00:00

abstract：:In adaptation to rising stimulant strength, innate monocytes can be dynamically programed to preferentially express either pro- or anti-inflammatory mediators. Such dynamic innate adaptation or programing may bear profound relevance in host health and disease. However, molecular mechanisms that govern innate adaptatio...

journal_title：Frontiers in immunology

authors： Yuan R,Geng S,Li L

更新日期：2016-11-10 00:00:00

abstract：:B cell activation and differentiation yields plasma cells with high affinity antibodies to a given antigen in a time-frame that allows for host protection. Although the end product is most commonly humoral immunity, the rapid proliferation and somatic mutation of the B cell receptor also results in oncogenic mutations...

journal_title：Frontiers in immunology

authors： Barwick BG,Gupta VA,Vertino PM,Boise LH

更新日期：2019-05-21 00:00:00

abstract：:The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM comp...

journal_title：Frontiers in immunology

authors： Lu HY,Bauman BM,Arjunaraja S,Dorjbal B,Milner JD,Snow AL,Turvey SE

更新日期：2018-09-19 00:00:00

abstract：:C-reactive protein (CRP), a humoral component of the innate immune system with important functions in host-defense, is extensively used as a sensitive biomarker of systemic inflammation. During inflammation, hepatocyte-derived CRP rises dramatically in the blood due to increased interleukin-6 (IL-6) levels. Reliable d...

journal_title：Frontiers in immunology

authors： Wetterö J,von Löhneysen S,Cobar F,Kristenson M,Garvin P,Sjöwall C

更新日期：2021-01-08 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and lig...

journal_title：Frontiers in immunology

authors： Franzin R,Netti GS,Spadaccino F,Porta C,Gesualdo L,Stallone G,Castellano G,Ranieri E

更新日期：2020-10-08 00:00:00

abstract：Background:The immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in attenuating clinical symptoms and in decreasing inflammatory mechan...

journal_title：Frontiers in immunology

authors： Bejar J,Kessler O,Sabag AD,Sabo E,Itzhak OB,Neufeld G,Vadasz Z

更新日期：2018-04-04 00:00:00

abstract：:Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Interferon γ (IFNγ)-primed macrophages stimulated with lipopolysaccharide (LPS) [M(IFNγ+LPS)] produce high levels of pro-inflammatory cytokines such as IL-12, TNFα, and IL-6 and low level...

journal_title：Frontiers in immunology

authors： Ruenjaiman V,Butta P,Leu YW,Pongpanich M,Leelahavanichkul A,Kueanjinda P,Palaga T

更新日期：2020-01-10 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00

abstract：:Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure. Correcting the patient's o...

journal_title：Frontiers in immunology

authors： Ott de Bruin LM,Volpi S,Musunuru K

更新日期：2015-05-21 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or more after diagnosis. Despite aggressive multimodal therapy, consisting mostly of a combination of surgery, radiotherapy, and temozolomi...

journal_title：Frontiers in immunology

authors： Pearson JRD,Cuzzubbo S,McArthur S,Durrant LG,Adhikaree J,Tinsley CJ,Pockley AG,McArdle SEB

更新日期：2020-10-15 00:00:00

abstract：:The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

journal_title：Frontiers in immunology

authors： Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

更新日期：2019-07-31 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:Mast cells constitutively express ß-catenin and expand in solid tumors such as colon and skin cancer. However, the role of ß-catenin signaling in mast cells and the cause or effect of mast cell expansion and tumor growth has yet to be established. In earlier studies we used mast cell depletion and protease staining ap...

journal_title：Frontiers in immunology

authors： Saadalla A,Lima MM,Tsai F,Osman A,Singh MP,Linden DR,Dennis KL,Haeryfar SMM,Gurish MF,Gounari F,Khazaie K

更新日期：2019-12-03 00:00:00

abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...

journal_title：Frontiers in immunology

authors： Tanaka Y,Nagai Y,Okumura M,Greene MI,Kambayashi T

更新日期：2020-04-09 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous pathogens including parasites, bacteria, and viruses. The contribu...

journal_title：Frontiers in immunology

authors： Saluja R,Metz M,Maurer M

更新日期：2012-06-13 00:00:00

abstract：:Despite effective antiretroviral therapy (ART), HIV-infected individuals with apparently similar clinical and immunological characteristics can vary in responsiveness to vaccinations. However, molecular mechanisms responsible for such impairment, as well as biomarkers able to predict vaccine responsiveness in HIV-infe...

journal_title：Frontiers in immunology

authors： Cotugno N,De Armas L,Pallikkuth S,Rinaldi S,Issac B,Cagigi A,Rossi P,Palma P,Pahwa S

更新日期：2017-09-11 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

journal_title：Frontiers in immunology

authors： Thompson KK,Nissen JC,Pretory A,Tsirka SE

更新日期：2018-11-28 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network and cytoskeletal re...

journal_title：Frontiers in immunology

authors： Ballek O,Valečka J,Dobešová M,Broučková A,Manning J,Řehulka P,Stulík J,Filipp D

更新日期：2016-10-27 00:00:00

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：Background:Selenium (Se) levels decrease in the circulation during acute inflammatory states and sepsis, and are inversely associated with morbidity and mortality. A more specific understanding of where selenoproteins and Se processing are compromised during insult is needed. We investigated the acute signaling respons...

journal_title：Frontiers in immunology

authors： Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

更新日期：2020-11-05 00:00:00

abstract：:Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis and to develop antiviral small molecules to treat infected ...

journal_title：Frontiers in immunology

authors： Nyanguile O

更新日期：2019-06-21 00:00:00

abstract：Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

journal_title：Frontiers in immunology

authors： Freitas ARR,Donalisio MR

更新日期：2018-01-08 00:00:00

abstract：:The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggeri...

journal_title：Frontiers in immunology

authors： Dushek O

更新日期：2012-01-10 00:00:00