Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity.

Abstract:

:The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictly extracellular protozoan parasites are confronted with different arms of the host's immune response (cellular as well as humoral) and via an elaborate and efficient (vector)-parasite-host interplay they have evolved efficient immune escape mechanisms to evade/manipulate the entire host immune response. This is of importance, since these parasites need to survive sufficiently long in their mammalian/vector host in order to complete their life cycle/transmission. Here, we will give an overview of the different mechanisms AT (i.e. T. brucei as a model organism) employ, comprising both tsetse fly saliva and parasite-derived components to modulate host innate immune responses thereby sculpturing an environment that allows survival and development within the mammalian host.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

doi

10.3389/fimmu.2016.00233

subject

Has Abstract

pub_date

2016-06-24 00:00:00

pages

233

issn

1664-3224

journal_volume

7

pub_type

杂志文章,评审
  • Corrigendum: Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression.

    abstract::[This corrects the article DOI: 10.3389/fimmu.2019.00702.]. ...

    journal_title:Frontiers in immunology

    pub_type: 已发布勘误

    doi:10.3389/fimmu.2020.592865

    authors: Ryffel B,Huang F,Robinet P,Panek C,Couillin I,Erard F,Piotet J,Le Bert M,Mackowiak C,Torres Arias M,Dimier-Poisson I,Zheng SG

    更新日期:2020-10-28 00:00:00

  • Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment.

    abstract::Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor cells and the number and activity of tumor-infiltrating T cells represent a good marker for tumor prognosis. Based on these findings, immunotherapy, e.g., checkpoint blockade, has received considerable attention during the last ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.00248

    authors: Renner K,Singer K,Koehl GE,Geissler EK,Peter K,Siska PJ,Kreutz M

    更新日期:2017-03-08 00:00:00

  • 1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.

    abstract::The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8+ T cells ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00320

    authors: Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

    更新日期:2017-03-22 00:00:00

  • The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.

    abstract::Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that rec...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01124

    authors: Paul S,Lal G

    更新日期:2017-09-13 00:00:00

  • Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

    abstract::Plasmodium vivax is the most common species that cause malaria outside of the African continent. The development of an efficacious vaccine would contribute greatly to control malaria. Recently, using bacterial and adenoviral recombinant proteins based on the P. vivax circumsporozoite protein (CSP), we demonstrated the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01275

    authors: Gimenez AM,Lima LC,Françoso KS,Denapoli PMA,Panatieri R,Bargieri DY,Thiberge JM,Andolina C,Nosten F,Renia L,Nussenzweig RS,Nussenzweig V,Amino R,Rodrigues MM,Soares IS

    更新日期:2017-10-11 00:00:00

  • Interplay of Regulatory T Cell and Th17 Cells during Infectious Diseases in Humans and Animals.

    abstract::It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.00341

    authors: Sehrawat S,Rouse BT

    更新日期:2017-04-03 00:00:00

  • A Rosetta Stone for Breast Cancer: Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment.

    abstract::Increasing evidence has revealed that the initiation and progression of breast cancer are greatly affected by the immune environment. Neutrophils are the most abundant leucocytes in circulation and act as the spearhead in inflammation, including in breast cancer. Circulating neutrophils are closely related to the prog...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.01779

    authors: Zhang W,Shen Y,Huang H,Pan S,Jiang J,Chen W,Zhang T,Zhang C,Ni C

    更新日期:2020-08-07 00:00:00

  • Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family.

    abstract::The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways. Various membrane-bound and plasma regulatory proteins control the activation of the potentially deleterious complement system. Am...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2018.01607

    authors: Sánchez-Corral P,Pouw RB,López-Trascasa M,Józsi M

    更新日期:2018-07-12 00:00:00

  • Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients.

    abstract::Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2016.00560

    authors: Toor SM,Syed Khaja AS,El Salhat H,Bekdache O,Kanbar J,Jaloudi M,Elkord E

    更新日期:2016-12-08 00:00:00

  • Innate Immune Cells in Immune Tolerance After Liver Transplantation.

    abstract::Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2018.02401

    authors: Huang H,Lu Y,Zhou T,Gu G,Xia Q

    更新日期:2018-11-09 00:00:00

  • Gut Microbiota and Bacterial DNA Suppress Autoimmunity by Stimulating Regulatory B Cells in a Murine Model of Lupus.

    abstract::Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We previously showed the suppressive effect of vancomycin treatment during the "active-disease" stage ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.593353

    authors: Mu Q,Edwards MR,Swartwout BK,Cabana Puig X,Mao J,Zhu J,Grieco J,Cecere TE,Prakash M,Reilly CM,Puglisi C,Bachali P,Grammer AC,Lipsky PE,Luo XM

    更新日期:2020-11-10 00:00:00

  • PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients.

    abstract:Background:The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use of anti-PD-L1/PD-1 antibodies in multiple myeloma (MM) patients still remains debated, at least in part because of discordant literature data on PD-L1...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.613007

    authors: Costa F,Vescovini R,Marchica V,Storti P,Notarfranchi L,Dalla Palma B,Toscani D,Burroughs-Garcia J,Catarozzo MT,Sammarelli G,Giuliani N

    更新日期:2021-01-08 00:00:00

  • Higher Frequencies of Lymphocytes Expressing the Natural Killer Group 2D Receptor in Patients With Behçet Disease.

    abstract::Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a l...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02157

    authors: Bonacini M,Soriano A,Zerbini A,Calò E,Cimino L,Muratore F,Fontana L,Braglia L,Parmeggiani M,Salvarani C,Croci S

    更新日期:2018-09-25 00:00:00

  • Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.02240

    authors: Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

    更新日期:2019-09-20 00:00:00

  • Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases.

    abstract::Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.00367

    authors: Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

    更新日期:2020-03-03 00:00:00

  • MicroRNA Functions in Thymic Biology: Thymic Development and Involution.

    abstract::During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critica...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2018.02063

    authors: Xu M,Gan T,Ning H,Wang L

    更新日期:2018-09-11 00:00:00

  • Myeloid Extracellular Vesicles: Messengers from the Demented Brain.

    abstract::Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2016.00017

    authors: Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

    更新日期:2016-01-29 00:00:00

  • Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines.

    abstract::Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.01344

    authors: Esposito S,Stefanelli P,Fry NK,Fedele G,He Q,Paterson P,Tan T,Knuf M,Rodrigo C,Weil Olivier C,Flanagan KL,Hung I,Lutsar I,Edwards K,O'Ryan M,Principi N,World Association of Infectious Diseases and Immunological Disorders

    更新日期:2019-07-03 00:00:00

  • Lactic Acid: A Novel Signaling Molecule in Early Pregnancy?

    abstract::Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnan...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.00279

    authors: Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AH

    更新日期:2020-02-27 00:00:00

  • A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity.

    abstract::The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to generate cross-reactive...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.01207

    authors: Sato-Kaneko F,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Cottam HB,Chan M,Chu PJ,Burkhart D,Schoener R,Matsutani T,Carson DA,Corr M,Hayashi T

    更新日期:2020-06-19 00:00:00

  • Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus Replication.

    abstract::Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with H...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.01757

    authors: Chen L,Wang C,Luo J,Su W,Li M,Zhao N,Lyu W,Attaran H,He Y,Ding H,He H

    更新日期:2017-12-12 00:00:00

  • Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology.

    abstract::Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2016.00140

    authors: Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

    更新日期:2016-04-19 00:00:00

  • Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries.

    abstract::Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.01961

    authors: Corbett AJ,Awad W,Wang H,Chen Z

    更新日期:2020-08-27 00:00:00

  • HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine.

    abstract::Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mong...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.3389/fimmu.2019.00428

    authors: Yao Y,Yang H,Shi L,Liu S,Li C,Chen J,Zhou Z,Sun M,Shi L

    更新日期:2019-03-08 00:00:00

  • A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.

    abstract:Introduction:C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isofo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.00675

    authors: Thiele JR,Zeller J,Kiefer J,Braig D,Kreuzaler S,Lenz Y,Potempa LA,Grahammer F,Huber TB,Huber-Lang M,Bannasch H,Stark GB,Peter K,Eisenhardt SU

    更新日期:2018-04-16 00:00:00

  • Toward the Discovery of Host-Defense Peptides in Plants.

    abstract::Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.01825

    authors: Petre B

    更新日期:2020-08-21 00:00:00

  • Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling.

    abstract::Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Neverthele...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.02187

    authors: Orbach R,Su X

    更新日期:2020-09-11 00:00:00

  • MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.

    abstract::Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.02462

    authors: Hawez A,Al-Haidari A,Madhi R,Rahman M,Thorlacius H

    更新日期:2019-11-01 00:00:00

  • NIH3T3 Directs Memory-Fated CTL Programming and Represses High Expression of PD-1 on Antitumor CTLs.

    abstract::Memory CD8+ T cells have long been considered a promising population for adoptive cell therapy (ACT) due to their long-term persistence and robust re-stimulatory response. NIH3T3 is an immortalized mouse embryonic fibroblast cell line. We report that NIH3T3-conditioned medium (CM) can augment effector functions of CTL...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.00761

    authors: Qin Y,Lee Y,Seo J,Kim T,Shin JH,Park SH

    更新日期:2019-04-11 00:00:00

  • Quantitative Measurement of Naïve T Cell Association With Dendritic Cells, FRCs, and Blood Vessels in Lymph Nodes.

    abstract::T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01571

    authors: Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

    更新日期:2018-07-26 00:00:00