MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.

abstract：:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...

journal_title：Frontiers in immunology

authors： Costa MC,Paixão CS,Viana DL,Rocha BO,Saldanha M,da Mota LMH,Machado PRL,Pagliari C,de Oliveira MF,Arruda S,Carvalho EM,Carvalho LP

更新日期：2020-03-25 00:00:00

abstract：:A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein....

journal_title：Frontiers in immunology

authors： Naz A,Shahid F,Butt TT,Awan FM,Ali A,Malik A

更新日期：2020-07-10 00:00:00

abstract：:Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is an SLE risk gene of previously unknown function. We undertook the pre...

journal_title：Frontiers in immunology

authors： Harris VM,Koelsch KA,Kurien BT,Harley ITW,Wren JD,Harley JB,Scofield RH

更新日期：2019-10-21 00:00:00

abstract：:Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth. Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will attempt to eliminate these pathogens using a combination of immune defense strategies. These include the recruitment of macrophages and other...

journal_title：Frontiers in immunology

authors： BoseDasgupta S,Pieters J

更新日期：2014-10-08 00:00:00

abstract：:Neutrophils are known to extrude decondensed chromatin, thus forming NETs (neutrophil extracellular traps). These structures immobilize pathogens, thereby preventing their spreading, and are also adorned with antimicrobial molecules. NETs can also influence pathogenesis in chronic inflammation, autoimmunity, and cance...

journal_title：Frontiers in immunology

authors： Tatsiy O,McDonald PP

更新日期：2018-09-18 00:00:00

abstract：:Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ult...

journal_title：Frontiers in immunology

authors： Reinherz EL,Keskin DB,Reinhold B

更新日期：2014-09-04 00:00:00

abstract：:DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can be quickly modified to combat emerging infectious threats, but often fail to generate a strong immunologic response limiting enthusiasm for their use in humans ...

journal_title：Frontiers in immunology

authors： Solodushko V,Bitko V,Barrington R,Fouty B

更新日期：2019-10-11 00:00:00

abstract：:Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in HIV+ individuals. Here, we analyzed a cohort of HIV+ men who have sex ...

journal_title：Frontiers in immunology

authors： Hearps AC,Agius PA,Zhou J,Brunt S,Chachage M,Angelovich TA,Cameron PU,Giles M,Price P,Elliott J,Jaworowski A

更新日期：2017-06-30 00:00:00

abstract：:We conducted a prospective study of 312 patients (194 with multiple myeloma, 118 with lymphomas) receiving high-dose conditioning chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT). Polymorphisms of MBL2 and MASP2 genes were investigated and serial measurements of serum concentrations of m...

journal_title：Frontiers in immunology

authors： Świerzko AS,Michalski M,Sokołowska A,Nowicki M,Eppa Ł,Szala-Poździej A,Mitrus I,Szmigielska-Kapłon A,Sobczyk-Kruszelnicka M,Michalak K,Gołos A,Wierzbowska A,Giebel S,Jamroziak K,Kowalski ML,Brzezińska O,Thiel S,Jenseniu

更新日期：2018-09-20 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:B-cell expansion with NF-κB and T-cell anergy (BENTA) disease is a B-cell-specific lymphoproliferative disorder caused by germline gain-of-function mutations in CARD11. These mutations force the CARD11 scaffold into an open conformation capable of stimulating constitutive NF-κB activation in lymphocytes, without requi...

journal_title：Frontiers in immunology

authors： Arjunaraja S,Angelus P,Su HC,Snow AL

更新日期：2018-02-08 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses. Neuroinflammation is a well-established fea...

journal_title：Frontiers in immunology

authors： Pietronigro EC,Della Bianca V,Zenaro E,Constantin G

更新日期：2017-03-02 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：:The last decade has seen much progress in adjunctive cell therapy for immune disorders. Both corporate and institutional Phase III studies have been run using mesenchymal stromal cells (MSC) for treatment of Graft versus Host Disease (GvHD), and product approval has been achieved for treatment of pediatric GvHD in Can...

journal_title：Frontiers in immunology

authors： Vaes B,Van't Hof W,Deans R,Pinxteren J

更新日期：2012-11-27 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Mechanisms driving acute graft-versus-host disease (aGVHD) onset in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are still poorly understood. To provide a detailed characterization of tissue-infiltrating T lymphocytes (TL) and search for eventual site-specific specificities, we de...

journal_title：Frontiers in immunology

authors： Alhaj Hussen K,Michonneau D,Biajoux V,Keita S,Dubouchet L,Nelson E,Setterblad N,Le Buanec H,Bouaziz JD,Guimiot F,Socié G,Canque B

更新日期：2020-11-24 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required ...

journal_title：Frontiers in immunology

authors： Brzostek J,Gascoigne NR,Rybakin V

更新日期：2016-02-04 00:00:00

abstract：:Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger adults. Unfortunately, influenza vaccine responses tend to be impaired in older adults due to aging of the immune system (immunosenescence). Latent infection with cy...

journal_title：Frontiers in immunology

authors： van den Berg SPH,Wong A,Hendriks M,Jacobi RHJ,van Baarle D,van Beek J

更新日期：2018-01-29 00:00:00

abstract：:Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

journal_title：Frontiers in immunology

authors： Korn T,Muschaweckh A

更新日期：2019-11-14 00:00:00

abstract：:The diversity of the immune repertoire is important for the adaptive immune system's ability to detect pathogens. Much of this diversity is generated in two steps, first through the recombination of germline gene segments and second through hypermutation during an immune response. While both steps are to some extent b...

journal_title：Frontiers in immunology

authors： Schwartz GW,Hershberg U

更新日期：2013-11-08 00:00:00

abstract：:B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R expression in RA. Flo...

journal_title：Frontiers in immunology

authors： Dam EM,Maier AC,Hocking AM,Carlin J,Ng B,Buckner JH

更新日期：2018-09-05 00:00:00

abstract：:Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence neoplastic cell functional behavior, remodeling TME and generating a tumor cell niche that supports tissue neovascularization, tumor invasion an...

journal_title：Frontiers in immunology

authors： Poggi A,Varesano S,Zocchi MR

更新日期：2018-02-19 00:00:00

abstract：:The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate i...

journal_title：Frontiers in immunology

authors： Sherman H,Gitschier HJ,Rossi AE

更新日期：2018-04-23 00:00:00

abstract：:Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human. Further, any invol...

journal_title：Frontiers in immunology

authors： Kroczek RA,Henn V

更新日期：2012-02-10 00:00:00

abstract：OBJECTIVE:Multiple solid cancers contain tertiary lymphoid organs (TLO). However, it is unclear whether they promote tumor rejection, facilitate tumor evasion, or simply whether they are a byproduct of chronic inflammation. We hypothesize that although chronic inflammation induces TLO formation, the tumor milieu can mo...

journal_title：Frontiers in immunology

authors： García-Hernández ML,Uribe-Uribe NO,Espinosa-González R,Kast WM,Khader SA,Rangel-Moreno J

更新日期：2017-05-17 00:00:00

abstract：:Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of ot...

journal_title：Frontiers in immunology

authors： McDaniel DK,Ringel-Scaia VM,Morrison HA,Coutermarsh-Ott S,Council-Troche M,Angle JW,Perry JB,Davis G,Leng W,Minarchick V,Yang Y,Chen B,Reece SW,Brown DA,Cecere TE,Brown JM,Gowdy KM,Hochella MF Jr,Allen IC

更新日期：2019-11-28 00:00:00

abstract：:The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorgan...

journal_title：Frontiers in immunology

authors： Covián C,Fernández-Fierro A,Retamal-Díaz A,Díaz FE,Vasquez AE,Lay MK,Riedel CA,González PA,Bueno SM,Kalergis AM

更新日期：2019-11-29 00:00:00

abstract：:Immunotherapy using checkpoint inhibitor targeting PD-1 and PD-L1 revolutionized the treatment of microsatellite instable metastatic colon cancer. Such treatment is now a standard of care for these patients. However, when used as monotherapy checkpoint inhibitors targeting PD-1 and PD-L1 are not effective in metastati...

journal_title：Frontiers in immunology

authors： Ghiringhelli F,Fumet JD

更新日期：2019-08-06 00:00:00