Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis.

abstract：:Glioblastoma (GBM) is the most malignant form of astrocytoma with short survival and a high recurrence rate and remains a global problem. Currently, surgery, chemotherapy, radiotherapy, and other comprehensive treatments are the main treatment modalities, but patients still have a poor prognosis mainly due to the infi...

journal_title：Frontiers in immunology

authors： Kang X,Zheng Y,Hong W,Chen X,Li H,Huang B,Huang Z,Tang H,Geng W

更新日期：2020-10-21 00:00:00

abstract：:The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questi...

journal_title：Frontiers in immunology

authors： Ruiz A,Blanch-Lombarte O,Jimenez-Moyano E,Ouchi D,Mothe B,Peña R,Galvez C,Genescà M,Martinez-Picado J,Goulder P,Barnard R,Howell B,Clotet B,Prado JG

更新日期：2019-01-22 00:00:00

abstract：:Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...

journal_title：Frontiers in immunology

authors： Turner JS,Day A,Alsoussi WB,Liu Z,O'Halloran JA,Presti RM,Patterson BK,Whelan SPJ,Ellebedy AH,Mudd PA

更新日期：2021-01-08 00:00:00

abstract：:B cell activation via the B cell receptor (BCR) signalosome involves participation of signaling molecules such as BTK and BLNK. Genetic defects in these molecules are known to impair B cell differentiation and subsequently lead to agammaglobulinemia. Here we identified novel mutations in BTK and BLNK in two unrelated ...

journal_title：Frontiers in immunology

authors： Geier CB,Sauerwein KMT,Leiss-Piller A,Zmek I,Fischer MB,Eibl MM,Wolf HM

更新日期：2018-12-18 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:Autophagy was initially characterized as a process to digest cellular components, including damaged cell organelles or unused proteins. However, later studies showed that autophagy plays an important role to protect hosts from microbial infections. Accumulating evidences showed the contribution of autophagy itself and...

journal_title：Frontiers in immunology

authors： Kanayama M,Shinohara ML

更新日期：2016-02-18 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbid...

journal_title：Frontiers in immunology

authors： Campillay-Véliz CP,Carvajal JJ,Avellaneda AM,Escobar D,Covián C,Kalergis AM,Lay MK

更新日期：2020-06-16 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) possess a diverse array of regulatory functions including activation and silencing of gene transcription, regulation of splicing, and coordinating epigenetic modifications. GATA3-AS1 is a divergent lncRNA gene neighboring GATA3. GATA3 is considered the master regulator of TH2 lineage com...

journal_title：Frontiers in immunology

authors： Gibbons HR,Shaginurova G,Kim LC,Chapman N,Spurlock CF 3rd,Aune TM

更新日期：2018-10-29 00:00:00

abstract：:Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of ...

journal_title：Frontiers in immunology

authors： Lundy SK,Klinker MW,Fox DA

更新日期：2015-03-20 00:00:00

abstract：:The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challe...

journal_title：Frontiers in immunology

authors： Sandbrink JB,Shattock RJ

更新日期：2020-12-22 00:00:00

abstract：:Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activa...

journal_title：Frontiers in immunology

authors： Antonangeli F,Soriani A,Cerboni C,Sciumè G,Santoni A

更新日期：2017-11-20 00:00:00

abstract：:Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects of single supply or...

journal_title：Frontiers in immunology

authors： Nhu TQ,Bich Hang BT,Cornet V,Oger M,Bach LT,Anh Dao NL,Thanh Huong DT,Quetin-Leclercq J,Scippo ML,Phuong NT,Kestemont P

更新日期：2020-05-05 00:00:00

abstract：:HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of people living with HIV-2 (PLWHIV-2), compared to blood bank heal...

journal_title：Frontiers in immunology

authors： Iannetta M,Isnard S,Manuzak J,Guillerme JB,Notin M,Bailly K,Andrieu M,Amraoui S,Vimeux L,Figueiredo S,Charmeteau-de Muylder B,Vaton L,Hatton EX,Samri A,Autran B,Thiébaut R,Chaghil N,Glohi D,Charpentier C,Descamps D

更新日期：2020-08-13 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

journal_title：Frontiers in immunology

authors： Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

更新日期：2018-04-19 00:00:00

abstract：:Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the establishment of protein antigen-specific B cell memory and long-lived pla...

journal_title：Frontiers in immunology

authors： Lang ML

更新日期：2018-02-22 00:00:00

abstract：:Our immune system bears the tremendous task of mounting effective anti-microbial responses whilst maintaining immunoregulatory functions to avoid autoimmunity. In order to quickly respond to pathogens, Dendritic cells (DC) are armed with pattern recognition receptors (PRRs), allowing them to recognize highly conserved...

journal_title：Frontiers in immunology

authors： Ng D,Gommerman JL

更新日期：2013-04-22 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00

abstract：:Differentiation of Natural Killer (NK) cells is a stepwise process having its origin in the bone marrow and proceeding in the periphery, where these cells follow organ specific trajectories. Several soluble factors and cytokines regulate the distinct stages of NK cell differentiation, and ultimately, their functional ...

journal_title：Frontiers in immunology

authors： Scarno G,Pietropaolo G,Di Censo C,Gadina M,Santoni A,Sciumè G

更新日期：2019-10-17 00:00:00

abstract：:Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mong...

journal_title：Frontiers in immunology

authors： Yao Y,Yang H,Shi L,Liu S,Li C,Chen J,Zhou Z,Sun M,Shi L

更新日期：2019-03-08 00:00:00

abstract：:Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged as an attractive al...

journal_title：Frontiers in immunology

authors： Amini L,Vollmer T,Wendering DJ,Jurisch A,Landwehr-Kenzel S,Otto NM,Jürchott K,Volk HD,Reinke P,Schmueck-Henneresse M

更新日期：2019-05-28 00:00:00

abstract：:Background: Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. T...

journal_title：Frontiers in immunology

authors： Cussotto S,Delgado I,Anesi A,Dexpert S,Aubert A,Beau C,Forestier D,Ledaguenel P,Magne E,Mattivi F,Capuron L

更新日期：2020-04-15 00:00:00

abstract：:Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

journal_title：Frontiers in immunology

authors： Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

更新日期：2019-08-23 00:00:00

abstract：:The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises ...

journal_title：Frontiers in immunology

authors： Sciumè G,Shih HY,Mikami Y,O'Shea JJ

更新日期：2017-11-13 00:00:00

abstract：:Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15-40% of melanoma patients and resistance is associated with defects in antigen presentation and interferon signa...

journal_title：Frontiers in immunology

authors： Alavi S,Stewart AJ,Kefford RF,Lim SY,Shklovskaya E,Rizos H

更新日期：2018-06-21 00:00:00

abstract：:The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones, differentiate, and acquire an effector phenotype. Despite growing ex...

journal_title：Frontiers in immunology

authors： Azarov I,Peskov K,Helmlinger G,Kosinsky Y

更新日期：2019-06-11 00:00:00

abstract：:The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects chan...

journal_title：Frontiers in immunology

authors： Wehbi VL,Taskén K

更新日期：2016-06-08 00:00:00

abstract：:Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cancer therapy has intensified interest in immunoediting as a constraint l...

journal_title：Frontiers in immunology

authors： Huang SH,McCann CD,Mota TM,Wang C,Lipkin SM,Jones RB

更新日期：2019-08-06 00:00:00

abstract：:Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as well as staphylococ...

journal_title：Frontiers in immunology

authors： Kale SD,Mehrkens BN,Stegman MM,Kastelberg B,Carnes H,McNeill RJ,Rizzo A,Karyala SV,Coutermarsh-Ott S,Fretz JA,Sun Y,Koff JL,Rajagopalan G

更新日期：2020-06-26 00:00:00