Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations.

abstract：:For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve pa...

journal_title：Frontiers in immunology

authors： Ghimire S,Weber D,Mavin E,Wang XN,Dickinson AM,Holler E

更新日期：2017-03-20 00:00:00

abstract：:Natural killer (NK) cells are innate immune lymphocytes with potent cytolytic and immune-regulatory activities. NK cells are well-known for their ability to kill infected and malignant cells in a fast and non-specific way without prior sensitization. For this purpose, NK cells are equipped with a set of cytotoxic mole...

journal_title：Frontiers in immunology

authors： Vandenhaute J,Wouters CH,Matthys P

更新日期：2020-01-15 00:00:00

abstract：:New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early infection and host re...

journal_title：Frontiers in immunology

authors： Rosenbaum P,Tchitchek N,Joly C,Stimmer L,Hocini H,Dereuddre-Bosquet N,Beignon AS,Chapon C,Levy Y,Le Grand R,Martinon F

更新日期：2018-04-25 00:00:00

abstract：:COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outco...

journal_title：Frontiers in immunology

authors： Peng X,Ouyang J,Isnard S,Lin J,Fombuena B,Zhu B,Routy JP

更新日期：2020-12-15 00:00:00

abstract：Background:Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or IL18 polymorphism p...

journal_title：Frontiers in immunology

authors： Gomes Dos Santos A,Watanabe EH,Ferreira DT,Oliveira J,Nakanishi ÉS,Oliveira CS,Bocchi E,Novaes CTG,Cruz F,Carvalho NB,Sato PK,Yamashiro-Kanashiro EH,Pontillo A,de Freitas VLT,Onuchic LF,Shikanai-Yasuda MA

更新日期：2020-10-22 00:00:00

abstract：:Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

journal_title：Frontiers in immunology

authors： Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

更新日期：2019-03-29 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

journal_title：Frontiers in immunology

authors： Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

更新日期：2020-11-24 00:00:00

abstract：:Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

journal_title：Frontiers in immunology

authors： Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

更新日期：2020-02-14 00:00:00

abstract：:Despite continuous exposure and development of specific immunity, Staphylococcus aureus (Sa) remains one of the leading causes of severe infections worldwide. Although innate immune defense mechanisms are well understood, the role of the T cell response has not been fully elucidated. Here, we demonstrate that Sa and o...

journal_title：Frontiers in immunology

authors： Uebele J,Habenicht K,Ticha O,Bekeredjian-Ding I

更新日期：2020-09-30 00:00:00

abstract：:CD4+ regulatory T cells have been intensively studied during aging, but little is still known about age-related changes of other regulatory T cell subsets. It was, therefore, the goal of the present study to analyze CD8+human leukocyte antigen-antigen D related (HLADR)+ T cells in old age, a cell population reported t...

journal_title：Frontiers in immunology

authors： Lukas Yani S,Keller M,Melzer FL,Weinberger B,Pangrazzi L,Sopper S,Trieb K,Lobina M,Orrù V,Fiorillo E,Cucca F,Grubeck-Loebenstein B

更新日期：2018-06-04 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00

abstract：:Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed after antigen clearance and a long-term resting phase accompanied ...

journal_title：Frontiers in immunology

authors： Onodera A,Kokubo K,Nakayama T

更新日期：2018-12-12 00:00:00

abstract：:Bovine neonatal pancytopenia (BNP) was a vaccine-induced alloimmune disease observed in young calves and characterized by hemorrhages, pancytopenia, and severe destruction of the hematopoietic tissues. BNP was induced by alloreactive maternal antibodies present in the colostrum of certain cows vaccinated with a highly...

journal_title：Frontiers in immunology

authors： Kasonta R,Mauritz J,Spohr C,Sauter-Louis C,Duchow K,Cussler K,Holsteg M,Bastian M

更新日期：2018-08-14 00:00:00

abstract：:PD-1, TIM-3, and LAG-3 are molecules shown to have immune modulatory properties, and although initially classified as indicators of T cell hyporesponsiveness, it has become clear that they are also associated with the normal course of T cell activation. Functional studies have focused mainly on CD8(+) T cells during c...

journal_title：Frontiers in immunology

authors： Sabins NC,Harman BC,Barone LR,Shen S,Santulli-Marotto S

更新日期：2016-06-16 00:00:00

abstract：:Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase. The syndrome encompasses combined immunodeficiency and various degrees of neurological a...

journal_title：Frontiers in immunology

authors： Mandola AB,Reid B,Sirror R,Brager R,Dent P,Chakroborty P,Bulman DE,Roifman CM

更新日期：2019-12-20 00:00:00

abstract：:Macrophages form an important component of the innate immune system and serve as first responders against invading pathogens. While pathways critical for initiation of inflammatory responses between macrophages and other LysM+ myeloid cells are largely similar, it remains unknown whether a specific pathway has differe...

journal_title：Frontiers in immunology

authors： Xiong X,Mathewson ND,Li H,Tan M,Fujiwara H,Li H,Reddy P,Sun Y

更新日期：2018-12-06 00:00:00

abstract：:TNFAIP3 encodes the NF-κB regulatory protein A20. High-penetrance heterozygous mutations in TNFAIP3 cause a haploinsufficiency of A20 (HA20), inadequate inhibition of NF-κB pathway, and an early onset autoinflammatory disorder. However, the clinical phenotype of patients with HA20 varies greatly and clinical diagnoses...

journal_title：Frontiers in immunology

authors： Lawless D,Pathak S,Scambler TE,Ouboussad L,Anwar R,Savic S

更新日期：2018-07-04 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells essential for the induction of adaptive immune responses. Their unprecedented ability to present antigens to T cells has made them excellent targets for vaccine development. In the last years, a new technology based on antigen delivery directly to different DC subsets...

journal_title：Frontiers in immunology

authors： Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

更新日期：2017-12-04 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune neurological disorder typified by skeletal muscle fatigue and most often production of autoantibodies against the nicotinic acetylcholine receptor (AChR). The present study was undertaken to assess the extent of AChR-peptide recognition in MG patients using co-culturing (DC:TC) ...

journal_title：Frontiers in immunology

authors： Sharma S,Malmeström C,Lindberg C,Meisel S,Schön K,Verolin M,Lycke NY

更新日期：2017-10-24 00:00:00

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

journal_title：Frontiers in immunology

authors： Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

更新日期：2018-08-14 00:00:00

abstract：:Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has ...

journal_title：Frontiers in immunology

authors： Davidov V,Jensen G,Mai S,Chen SH,Pan PY

更新日期：2020-09-02 00:00:00

abstract：:Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which...

journal_title：Frontiers in immunology

authors： Trim W,Turner JE,Thompson D

更新日期：2018-02-09 00:00:00

abstract：:Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical signs of infections in children, second, the early appearance of...

journal_title：Frontiers in immunology

authors： Fierz W,Walz B

更新日期：2020-06-05 00:00:00

abstract：:This is the first case of NBAS disease detected by NBS for primary immunodeficiency. NBS with KRECs is revealing unknown potentialities detecting conditions that benefit from early recognition like NBAS deficiency. Immune phenotyping should be mandatory in patients with NBAS deficiency since they can exhibit severe im...

journal_title：Frontiers in immunology

authors： Ricci S,Lodi L,Serranti D,Moroni M,Belli G,Mancano G,La Barbera A,Forzano G,Mangone G,Indolfi G,Azzari C

更新日期：2019-08-27 00:00:00

abstract：:The mechanistic requirements of antigen recognition by T cells expressing a γδ TCR has revealed important differences with those of αβ TCR cells and, despite impressive new data generated in the very recent years, they remain poorly understood. Based on the structure of the TCR chains and the tissue distribution, γδ c...

journal_title：Frontiers in immunology

authors： De Libero G,Lau SY,Mori L

更新日期：2015-01-15 00:00:00

abstract：:Due to limited sepsis patient cohort size and extreme heterogeneity, only one significant locus and suggestive associations at several independent loci were implicated by three genome-wide association studies. However, genes from such suggestive loci may also provide crucial information to unravel genetic mechanisms t...

journal_title：Frontiers in immunology

authors： Le KTT,Matzaraki V,Netea MG,Wijmenga C,Moser J,Kumar V

更新日期：2019-08-14 00:00:00