Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS.

abstract：:The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises ...

journal_title：Frontiers in immunology

authors： Sciumè G,Shih HY,Mikami Y,O'Shea JJ

更新日期：2017-11-13 00:00:00

abstract：:Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-c...

journal_title：Frontiers in immunology

authors： Sahasrabudhe NM,Beukema M,Tian L,Troost B,Scholte J,Bruininx E,Bruggeman G,van den Berg M,Scheurink A,Schols HA,Faas MM,de Vos P

更新日期：2018-03-01 00:00:00

abstract：:Background: Variants in recombination-activating genes (RAG) are common genetic causes of autosomal recessive forms of combined immunodeficiencies (CID) ranging from severe combined immunodeficiency (SCID), Omenn syndrome (OS), leaky SCID, and CID with granulomas and/or autoimmunity (CID-G/AI), and even milder present...

journal_title：Frontiers in immunology

authors： Sharapova SO,Skomska-Pawliszak M,Rodina YA,Wolska-Kuśnierz B,Dabrowska-Leonik N,Mikołuć B,Pashchenko OE,Pasic S,Freiberger T,Milota T,Formánková R,Szaflarska A,Siedlar M,Avčin T,Markelj G,Ciznar P,Kalwak K,Kołtan S,Ja

更新日期：2020-06-10 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and skin during development. However, the roles of IL34 and CSF1 at homeost...

journal_title：Frontiers in immunology

authors： Lin W,Xu D,Austin CD,Caplazi P,Senger K,Sun Y,Jeet S,Young J,Delarosa D,Suto E,Huang Z,Zhang J,Yan D,Corzo C,Barck K,Rajan S,Looney C,Gandham V,Lesch J,Liang WC,Mai E,Ngu H,Ratti N,Chen Y,Misner D,Lin T

更新日期：2019-09-04 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:A growing number of diseases in humans, including trauma, certain cancers, and infection, are known to be associated with l-arginine deficiency. In addition, l-arginine must be supplemented by diet during pregnancy to aid fetal development. In conditions of l-arginine depletion, T cell proliferation is impaired. We ha...

journal_title：Frontiers in immunology

authors： Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

更新日期：2017-04-25 00:00:00

abstract：:Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell repertoires of pat...

journal_title：Frontiers in immunology

authors： Arakawa A,Vollmer S,Tietze J,Galinski A,Heppt MV,Bürdek M,Berking C,Prinz JC

更新日期：2019-06-18 00:00:00

abstract：:The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

journal_title：Frontiers in immunology

authors： Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

更新日期：2017-03-07 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

journal_title：Frontiers in immunology

authors： Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

更新日期：2019-09-20 00:00:00

abstract：:Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

journal_title：Frontiers in immunology

authors： Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

更新日期：2019-01-31 00:00:00

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymphocytes toward cancer cells by bispecific antibodies (bsAbs) that eng...

journal_title：Frontiers in immunology

authors： Satta A,Grazia G,Caroli F,Frigerio B,Di Nicola M,Raspagliesi F,Mezzanzanica D,Zaffaroni N,Gianni AM,Anichini A,Figini M

更新日期：2019-10-25 00:00:00

abstract：:The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of new antibiotics is notoriously costly and slow; therefore, alternative strategies are needed. Antimicrobial peptides (AMPs), the central effector molecules of the...

journal_title：Frontiers in immunology

authors： Geitani R,Moubareck CA,Xu Z,Karam Sarkis D,Touqui L

更新日期：2020-06-30 00:00:00

abstract：:Background: Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic lesions are a consequence of renal inflammation or independently contribute to renal damage is unclear. Our aim was to investigate the relationship bet...

journal_title：Frontiers in immunology

authors： Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M

更新日期：2018-08-28 00:00:00

abstract：:We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice. Although the protective effects were ascribed to the induction of ad...

journal_title：Frontiers in immunology

authors： Horwitz DA,Liu A,Bickerton S,Castaldo G,Matarese G,Fahmy TM,La Cava A

更新日期：2020-12-16 00:00:00

abstract：Background:Selenium (Se) levels decrease in the circulation during acute inflammatory states and sepsis, and are inversely associated with morbidity and mortality. A more specific understanding of where selenoproteins and Se processing are compromised during insult is needed. We investigated the acute signaling respons...

journal_title：Frontiers in immunology

authors： Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

更新日期：2020-11-05 00:00:00

abstract：:Regulatory T cells play an important role in the control of autoimmune diseases and maintenance of tolerance. In the context of transplantation, regulatory T cells (Tregs) have been proposed as new therapeutic tools that may induce allospecific tolerance toward the graft, avoiding the side effects induced by generaliz...

journal_title：Frontiers in immunology

authors： Alvarez-Salazar EK,Cortés-Hernández A,Arteaga-Cruz S,Alberú-Gómez J,Soldevila G

更新日期：2020-04-02 00:00:00

abstract：:Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor kidney for rejection, and contributes to the long-term risk of graft loss. In the last decade, epidemiological studies have linked ...

journal_title：Frontiers in immunology

authors： Tammaro A,Kers J,Scantlebery AML,Florquin S

更新日期：2020-07-07 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00

abstract：:Proteinuria has been identified as prognosticator of renal outcome in patients with ANCA-associated glomerulonephritis, but whether proteinuria is related to podocyte abnormalities in these patients is largely unknown. We here investigate podocyte foot process width and number of podocytes positive for the podocyte ma...

journal_title：Frontiers in immunology

authors： van Daalen EE,Neeskens P,Zandbergen M,Harper L,Karras A,Vaglio A,de Zoysa J,Bruijn JA,Bajema IM

更新日期：2019-06-26 00:00:00

abstract：:Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphati...

journal_title：Frontiers in immunology

authors： Soloff AC,Jones KE,Powers AA,Murthy P,Wang Y,Russell KL,Byrne-Steele M,Lund AW,Yuan JM,Monaco SE,Han J,Dhupar R,Lotze MT

更新日期：2020-09-04 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapabl...

journal_title：Frontiers in immunology

authors： Nikolaev EV,Zloza A,Sontag ED

更新日期：2019-01-28 00:00:00

abstract：:Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

journal_title：Frontiers in immunology

authors： Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

更新日期：2016-10-31 00:00:00

abstract：:γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

journal_title：Frontiers in immunology

authors： Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

更新日期：2017-01-09 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...

journal_title：Frontiers in immunology

authors： Costa MC,Paixão CS,Viana DL,Rocha BO,Saldanha M,da Mota LMH,Machado PRL,Pagliari C,de Oliveira MF,Arruda S,Carvalho EM,Carvalho LP

更新日期：2020-03-25 00:00:00

abstract：:Immunotherapy approaches currently make their way into the clinics to improve the outcome of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) is one possible target that, upon blockade, allows T cell-dependent antitumor immune responses to be executed. To date, it is unclear which R...

journal_title：Frontiers in immunology

authors： Derer A,Spiljar M,Bäumler M,Hecht M,Fietkau R,Frey B,Gaipl US

更新日期：2016-12-22 00:00:00