l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes.

abstract：:For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that interactions between malignant cells and neighboring stromal and immune cells-the tumor microenvironment (TME)-profoundly ...

journal_title：Frontiers in immunology

authors： Haas L,Obenauf AC

更新日期：2019-11-28 00:00:00

abstract：:IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases of PI3K. Our experim...

journal_title：Frontiers in immunology

authors： Ten Broeke T,Honing H,Brandsma AM,Jacobino S,Bakema JE,Kanters D,van der Linden JAM,Bracke M,Koenderman L,Leusen JHW

更新日期：2019-01-31 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

journal_title：Frontiers in immunology

authors： Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

更新日期：2017-06-26 00:00:00

abstract：:Anti-drug antibodies to coagulation factor VIII (fVIII), often termed inhibitors, present the greatest economical and treatment related obstacle in the management of hemophilia A. Although several genetic and environmental risk factors associated with inhibitor development have been identified, the precise mechanisms ...

journal_title：Frontiers in immunology

authors： Zakas PM,Healey JF,Smith IW,Lillicrap D,Lollar P

更新日期：2020-02-07 00:00:00

abstract：:The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth fa...

journal_title：Frontiers in immunology

authors： Foster SL,Seehus CR,Woolf CJ,Talbot S

更新日期：2017-11-03 00:00:00

abstract：:The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

journal_title：Frontiers in immunology

authors： Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

更新日期：2019-09-26 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：:Glioblastoma (GBM) is the most malignant form of astrocytoma with short survival and a high recurrence rate and remains a global problem. Currently, surgery, chemotherapy, radiotherapy, and other comprehensive treatments are the main treatment modalities, but patients still have a poor prognosis mainly due to the infi...

journal_title：Frontiers in immunology

authors： Kang X,Zheng Y,Hong W,Chen X,Li H,Huang B,Huang Z,Tang H,Geng W

更新日期：2020-10-21 00:00:00

abstract：:Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in o...

journal_title：Frontiers in immunology

authors： Camaioni A,Klinger FG,Campagnolo L,Salustri A

更新日期：2018-11-29 00:00:00

abstract：:TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

journal_title：Frontiers in immunology

authors： Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

更新日期：2017-10-03 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common path...

journal_title：Frontiers in immunology

authors： Kawakami T,Ando T,Kawakami Y

更新日期：2015-08-24 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01137.]. ...

journal_title：Frontiers in immunology

authors： Luchini LSG,Pidde G,Squaiella-Baptistão CC,Tambourgi DV

更新日期：2019-07-03 00:00:00

abstract：:Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to fight against pathogen infection and tumors. Because of their abilit...

journal_title：Frontiers in immunology

authors： Takami M,Ihara F,Motohashi S

更新日期：2018-09-07 00:00:00

abstract：:Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in 1967. The etiology of KD has been studied comprehensively but remains largely unknown. The disease seems to result from the interplay of genetic and environmental susceptibility factors with infectious triggers, followed by a subsequent abnormal imm...

journal_title：Frontiers in immunology

authors： Kaneko K,Akagawa S,Akagawa Y,Kimata T,Tsuji S

更新日期：2020-07-24 00:00:00

abstract：:During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most im...

journal_title：Frontiers in immunology

authors： Rider P,Kaplanov I,Romzova M,Bernardis L,Braiman A,Voronov E,Apte RN

更新日期：2012-09-14 00:00:00

abstract：:The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for...

journal_title：Frontiers in immunology

authors： Domnich M,Riedesel J,Pylaeva E,Kürten CHL,Buer J,Lang S,Jablonska J

更新日期：2020-10-09 00:00:00

abstract：:In humans, loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3) gene is frequently associated with susceptibility to bacterial as well as fungal infections including aspergillosis, although its pathogenesis remains largely unknown. In the present study, we investigated the immune...

journal_title：Frontiers in immunology

authors： Danion F,Aimanianda V,Bayry J,Duréault A,Wong SSW,Bougnoux ME,Tcherakian C,Alyanakian MA,Guegan H,Puel A,Picard C,Lortholary O,Lanternier F,Latgé JP

更新日期：2020-01-28 00:00:00

abstract：:c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells. Invariant natural killer T (iNKT) cells can rapidly produce large quantity of TH-related cytokines such as IFN-γ, IL-4, and IL-17A upon stim...

journal_title：Frontiers in immunology

authors： Yu JS,Hamada M,Ohtsuka S,Yoh K,Takahashi S,Miaw SC

更新日期：2017-10-27 00:00:00

abstract：:T cells are the main orchestrators of protective immunity in the stomach; however, limited information on the presence and function of the gastric T subsets is available mainly due to the difficulty in recovering high numbers of viable cells from human gastric biopsies. To overcome this shortcoming we optimized a cell...

journal_title：Frontiers in immunology

authors： Booth JS,Toapanta FR,Salerno-Goncalves R,Patil S,Kader HA,Safta AM,Czinn SJ,Greenwald BD,Sztein MB

更新日期：2014-06-19 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Cancer immunotherapy is currently the hottest topic in the oncology field, owing predominantly to the discovery of immune checkpoint blockers. These promising antibodies and their attractive combinatorial features have initiated the revival of other effective immunotherapies, such as dendritic cell (DC) vaccinations. ...

journal_title：Frontiers in immunology

authors： Vandenberk L,Belmans J,Van Woensel M,Riva M,Van Gool SW

更新日期：2016-01-14 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as well in murine Mtb infection models. However, the interaction of mycobacteria with MDSCs and its role in TB infection is not well studied. Here, we investigated the role of Ca...

journal_title：Frontiers in immunology

authors： John V,Kotze LA,Ribechini E,Walzl G,Du Plessis N,Lutz MB

更新日期：2019-12-03 00:00:00

abstract：:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tole...

journal_title：Frontiers in immunology

authors： Javidi E,Magnus T

更新日期：2019-04-02 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence of ~30,770 cases in the United States, MM has a high mortality rate, leading to 12,770 deaths per year. MM is a genetically complex, highly heterogeneo...

journal_title：Frontiers in immunology

authors： Caraccio C,Krishna S,Phillips DJ,Schürch CM

更新日期：2020-04-24 00:00:00

abstract：:Gastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing the intestinal epithelial barrier. The initial interaction of the intestinal epithelium with t...

journal_title：Frontiers in immunology

authors： Ebner F,Kuhring M,Radonić A,Midha A,Renard BY,Hartmann S

更新日期：2018-08-15 00:00:00

abstract：:The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. ...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,Ludwig I,van Kooten P,van der Zee R,Broere F

更新日期：2017-11-21 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques. Sufficient clearance of myelin and cellular debris is one of the requirements for proper tissue repair and remyelination. The mechanisms underlying the clearance o...

journal_title：Frontiers in immunology

authors： Kamermans A,Rijnsburger M,Chakraborty A,van der Pol S,de Vries HE,van Horssen J

更新日期：2019-05-03 00:00:00

abstract：:The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of mon...

journal_title：Frontiers in immunology

authors： Pellefigues C,Tang SC,Schmidt A,White RF,Lamiable O,Connor LM,Ruedl C,Dobrucki J,Le Gros G,Ronchese F

更新日期：2017-11-16 00:00:00