Sense and Immunity: Context-Dependent Neuro-Immune Interplay.

abstract：:The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell ...

journal_title：Frontiers in immunology

authors： Kielsen K,Enevold C,Heilmann C,Sengeløv H,Pedersen AE,Ryder LP,Müller K

更新日期：2018-02-02 00:00:00

abstract：:Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immatu...

journal_title：Frontiers in immunology

authors： Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

更新日期：2017-11-13 00:00:00

abstract：:Thymic epithelial cells (TECs) provide the microenvironment required for the development of T cells in the thymus. A unique property of medullary thymic epithelial cells (mTECs) is their expression of a wide range of tissue-restricted self-antigens, critically regulated by the nuclear protein AIRE, which contributes t...

journal_title：Frontiers in immunology

authors： Akiyama T,Shinzawa M,Akiyama N

更新日期：2012-09-04 00:00:00

abstract：:Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global becoming a new worldwide challenge. For more than a century since its discovery, it has remained neglected with no effective drugs or vaccines. The mechanisms by which Trypanosoma cruzi regulates and uses the...

journal_title：Frontiers in immunology

authors： Nde PN,Lima MF,Johnson CA,Pratap S,Villalta F

更新日期：2012-11-06 00:00:00

abstract：:Most of the few patients with homozygous CD70 deficiency described to date suffered from EBV-related malignancies in early childhood. We present a woman with CD70 deficiency diagnosed in adulthood. She presented in childhood with recurrent airway infections due to encapsulated bacteria, herpes zoster and a fulminant E...

journal_title：Frontiers in immunology

authors： Krüger R,Martin E,Dmytrus J,Feiterna-Sperling C,Meisel C,Unterwalder N,Kölsch U,Wahn V,Hofmann J,Korn P,Latour S,Boztug K,von Bernuth H

更新日期：2020-08-04 00:00:00

abstract：:Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding ...

journal_title：Frontiers in immunology

authors： Granofszky N,Farkas AM,Muckenhuber M,Mahr B,Unger L,Maschke S,Pilat N,Holly R,Wiletel M,Regele H,Wekerle T

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00

abstract：:Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which...

journal_title：Frontiers in immunology

authors： Trim W,Turner JE,Thompson D

更新日期：2018-02-09 00:00:00

abstract：:The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to ...

journal_title：Frontiers in immunology

authors： Yuan X,Cao H,Wang J,Tang K,Li B,Zhao Y,Cheng M,Qin H,Liu X,Zhang X

更新日期：2017-09-29 00:00:00

abstract：:Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organi...

journal_title：Frontiers in immunology

authors： Tarifeño-Saldivia E,Aguilar A,Contreras D,Mercado L,Morales-Lange B,Márquez K,Henríquez A,Riquelme-Vidal C,Boltana S

更新日期：2018-06-05 00:00:00

abstract：:Adoptive cell transfer therapy is currently one of the most promising approaches for cancer treatment. This therapy has some limitations, however, such as the dispersion of in vivo-administered cells, causing only a small proportion to reach the tumor. Nanotechnological approaches could offer a solution for this drawb...

journal_title：Frontiers in immunology

authors： Sanz-Ortega L,Rojas JM,Portilla Y,Pérez-Yagüe S,Barber DF

更新日期：2019-08-30 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. Methods: ...

journal_title：Frontiers in immunology

authors： Diao B,Wang C,Tan Y,Chen X,Liu Y,Ning L,Chen L,Li M,Liu Y,Wang G,Yuan Z,Feng Z,Zhang Y,Wu Y,Chen Y

更新日期：2020-05-01 00:00:00

abstract：:Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5-20%, even while under specific treatment. In humans and other species susceptible to fatal VL, such as dogs...

journal_title：Frontiers in immunology

authors： de Melo CVB,Hermida MD,Mesquita BR,Fontes JLM,Koning JJ,Solcà MDS,Benevides BB,Mota GBS,Freitas LAR,Mebius RE,Dos-Santos WLC

更新日期：2020-04-15 00:00:00

abstract：:The onset of hepatic disorders in patients with systemic lupus erythematosus (SLE) is frequent; however, the etiology and liver pathogenesis of SLE remain unknown. In the present study, the role of hepatic deposited immunoglobulin G (IgG) in SLE-derived liver damage was investigated. From a retrospective analysis of t...

journal_title：Frontiers in immunology

authors： Fang X,Zaman MH,Guo X,Ding H,Xie C,Zhang X,Deng GM

更新日期：2018-06-25 00:00:00

abstract：:The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor-specific antibodie...

journal_title：Frontiers in immunology

authors： Dahdal S,Saison C,Valette M,Bachy E,Pallet N,Lina B,Koenig A,Monneret G,Defrance T,Morelon E,Thaunat O

更新日期：2019-02-05 00:00:00

abstract：:Approximately 1.2 billion people suffer from fungal diseases worldwide. Arguably, the most serious manifestation occurs when pathogenic fungi infect the brain, often causing fatal meningoencephalitis. For most fungi, infection occurs via the vascular route. The organism must first be arrested in the brain microvascula...

journal_title：Frontiers in immunology

authors： Shi M,Mody CH

更新日期：2016-08-02 00:00:00

abstract：:IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circul...

journal_title：Frontiers in immunology

authors： Zachova K,Kosztyu P,Zadrazil J,Matousovic K,Vondrak K,Hubacek P,Julian BA,Moldoveanu Z,Novak Z,Kostovcikova K,Raska M,Mestecky J

更新日期：2020-02-28 00:00:00

abstract：:The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in...

journal_title：Frontiers in immunology

authors： Jogdand GM,Mohanty S,Devadas S

更新日期：2016-11-23 00:00:00

abstract：:Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1hi, tissue-resident memory populat...

journal_title：Frontiers in immunology

authors： Shwetank,Frost EL,Mockus TE,Ren HM,Toprak M,Lauver MD,Netherby-Winslow CS,Jin G,Cosby JM,Evavold BD,Lukacher AE

更新日期：2019-04-17 00:00:00

abstract：:Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins (laminins 411 and 511) in this monocyte to macrophage switch. C...

journal_title：Frontiers in immunology

authors： Li L,Song J,Chuquisana O,Hannocks MJ,Loismann S,Vogl T,Roth J,Hallmann R,Sorokin L

更新日期：2020-10-30 00:00:00

abstract：:Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

journal_title：Frontiers in immunology

authors： Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

更新日期：2017-12-18 00:00:00

abstract：:Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic...

journal_title：Frontiers in immunology

authors： Li B,Hu Y,Zhao Y,Cheng M,Qin H,Cheng T,Wang Q,Peng X,Zhang X

更新日期：2017-01-31 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

journal_title：Frontiers in immunology

authors： Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

更新日期：2020-01-23 00:00:00

abstract：:The apoptosis of hemocytes plays an essential function in shrimp immune defense against pathogen invasions. In order to further elucidate the differential apoptotic responses of the granulocytes and the hyalinocytes in Fenneropenaeus chinensis post WSSV infection, the characteristics of apoptotic dynamics and viral pr...

journal_title：Frontiers in immunology

authors： Cui C,Liang Q,Tang X,Xing J,Sheng X,Zhan W

更新日期：2020-12-07 00:00:00

abstract：:The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challe...

journal_title：Frontiers in immunology

authors： Sandbrink JB,Shattock RJ

更新日期：2020-12-22 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnan...

journal_title：Frontiers in immunology

authors： Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AH

更新日期：2020-02-27 00:00:00