Autoimmunity After Ischemic Stroke and Brain Injury.

Abstract:

:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tolerance mechanisms. In stroke patients, the detection of T cells and antibodies specific to neuronal antigens suggests a role of humoral adaptive immunity. In experimental models stroke leads to a significant increase of autoreactive T and B cells to CNS antigens. Lesion volume and functional outcome in stroke patients and murine stroke models are connected to antigen-specific responses to brain proteins. In patients with traumatic brain injury (TBI) a range of antibodies against brain proteins can be detected in serum samples. In this review, we will summarize the role of autoimmunity in post-lesional conditions and discuss the role of B and T cells and their potential neuroprotective or detrimental effects.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Javidi E,Magnus T

doi

10.3389/fimmu.2019.00686

subject

Has Abstract

pub_date

2019-04-02 00:00:00

pages

686

issn

1664-3224

journal_volume

10

pub_type

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