Abstract:
:The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of monocytes and neutrophils and the release of neutrophil extracellular traps (NETs). Nb also activates toll-like receptor 4 (TLR4) signaling with expression of Ifnb transcripts in the skin and the development of an IFN type I signature on helminth antigen-bearing dendritic cells in draining lymph nodes. Co-injection of Nb together with about 10,000 Gram-negative bacteria amplified this TLR4-dependent but NET-independent IFN type I response and enhanced the development of Th2 responses. Thus, a limited activation of antibacterial signaling pathways is able to boost antihelminthic responses, suggesting a role for bacterial sensing in the optimal induction of Th2 immunity.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Pellefigues C,Tang SC,Schmidt A,White RF,Lamiable O,Connor LM,Ruedl C,Dobrucki J,Le Gros G,Ronchese Fdoi
10.3389/fimmu.2017.01575subject
Has Abstractpub_date
2017-11-16 00:00:00pages
1575issn
1664-3224journal_volume
8pub_type
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