Epigenomic Views of Innate Lymphoid Cells.

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanism...

journal_title：Frontiers in immunology

authors： Jaronen M,Quintana FJ

更新日期：2014-10-20 00:00:00

abstract：:Therapeutic approaches that engage immune cells to treat cancer are becoming increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid tumor types. Most of the current immunotherapies focus on manipulating T cells, however, the tumor microenvironment (TME) is abundantly infiltrate...

journal_title：Frontiers in immunology

authors： Clappaert EJ,Murgaski A,Van Damme H,Kiss M,Laoui D

更新日期：2018-10-08 00:00:00

abstract：:Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

journal_title：Frontiers in immunology

authors： Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

更新日期：2018-10-16 00:00:00

abstract：Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

journal_title：Frontiers in immunology

authors： Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

更新日期：2018-08-14 00:00:00

abstract：:The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3(-) CD4(+) T cells able to secrete IL-10 in an antigen-specific manner, type 1 regulatory (Tr1) T cells. Although their s...

journal_title：Frontiers in immunology

authors： White AM,Wraith DC

更新日期：2016-09-14 00:00:00

abstract：:For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that interactions between malignant cells and neighboring stromal and immune cells-the tumor microenvironment (TME)-profoundly ...

journal_title：Frontiers in immunology

authors： Haas L,Obenauf AC

更新日期：2019-11-28 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, d...

journal_title：Frontiers in immunology

authors： Dolcino M,Pelosi A,Fiore PF,Patuzzo G,Tinazzi E,Lunardi C,Puccetti A

更新日期：2018-07-16 00:00:00

abstract：:Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphati...

journal_title：Frontiers in immunology

authors： Soloff AC,Jones KE,Powers AA,Murthy P,Wang Y,Russell KL,Byrne-Steele M,Lund AW,Yuan JM,Monaco SE,Han J,Dhupar R,Lotze MT

更新日期：2020-09-04 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

journal_title：Frontiers in immunology

authors： Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

更新日期：2017-12-18 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor nec...

journal_title：Frontiers in immunology

authors： Roberts CA,Dickinson AK,Taams LS

更新日期：2015-11-19 00:00:00

abstract：Background:Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was ...

journal_title：Frontiers in immunology

authors： Liu Y,Xie P,Jiang D,Liu J,Zhang J,Bian T,Shi J

更新日期：2020-12-07 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R expression in RA. Flo...

journal_title：Frontiers in immunology

authors： Dam EM,Maier AC,Hocking AM,Carlin J,Ng B,Buckner JH

更新日期：2018-09-05 00:00:00

abstract：:The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. ...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,Ludwig I,van Kooten P,van der Zee R,Broere F

更新日期：2017-11-21 00:00:00

abstract：:Chemokines and their cognate receptors have been identified as major factors initiating and governing cell movement and interaction. These ligands and their receptors are expressed on a wide variety of cells and act during steady-state migration as well as inflammatory recruitment. CCR6 is a non-promiscuous chemokine ...

journal_title：Frontiers in immunology

authors： Lee AY,Eri R,Lyons AB,Grimm MC,Korner H

更新日期：2013-07-15 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:T cells play a critical role in cancer control, but a range of potent immunosuppressive mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity. While various immunotherapies (IMTs) aiming at re-invigorating the T-cell-mediated anti-tumor response, such as immune checkpoint blockad...

journal_title：Frontiers in immunology

authors： Vigano S,Alatzoglou D,Irving M,Ménétrier-Caux C,Caux C,Romero P,Coukos G

更新日期：2019-06-06 00:00:00

abstract：:The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorgan...

journal_title：Frontiers in immunology

authors： Covián C,Fernández-Fierro A,Retamal-Díaz A,Díaz FE,Vasquez AE,Lay MK,Riedel CA,González PA,Bueno SM,Kalergis AM

更新日期：2019-11-29 00:00:00

abstract：:Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clin...

journal_title：Frontiers in immunology

authors： Carvalho LP,Passos S,Schriefer A,Carvalho EM

更新日期：2012-10-04 00:00:00

abstract：Background:Immunotherapies targeting CTLA-4 and PD-1 have elicited promising responses in a variety of cancers. However, the relatively low response rates warrant the identification of additional immunosuppressive pathways. V domain immunoglobulin suppressor of T cell activation (VISTA) plays a critical role in antitum...

journal_title：Frontiers in immunology

authors： Xie X,Zhang J,Shi Z,Liu W,Hu X,Qie C,Chen W,Wang Y,Wang L,Jiang J,Liu J

更新日期：2020-10-29 00:00:00

abstract：:In this review we discuss how the competition for cytokines between different cells of the immune system can shape the system wide immune response. We focus on interleukin-2 (IL-2) secretion by activated effector T cells (T(eff)) and on the competition for IL-2 consumption between T(eff) and regulatory T cells (T(reg)...

journal_title：Frontiers in immunology

authors： Höfer T,Krichevsky O,Altan-Bonnet G

更新日期：2012-09-05 00:00:00

abstract：:Human papillomavirus (HPV) vaccines are safe and effective in preventing HPV infection and cervical precancers. Neutralizing antibodies are thought to be the primary mechanism of protection for HPV vaccines, although the exact level required for protection has not been identified. Three common serological assays used ...

journal_title：Frontiers in immunology

authors： Toh ZQ,He L,Chen C,Huang A,Russell FM,Garland SM,Reyburn R,Ratu T,Tuivaga E,Frazer IH,Mulholland EK,Licciardi PV

更新日期：2020-10-28 00:00:00

abstract：:Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biol...

journal_title：Frontiers in immunology

authors： Rahman S,Gadjeva M

更新日期：2014-08-11 00:00:00

abstract：:γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the ...

journal_title：Frontiers in immunology

authors： Kim G,Gu MJ,Kim SJ,Ko KH,Kye YC,Kim CG,Cho JH,Lee WK,Song KD,Chu H,Park YM,Han SH,Yun CH

更新日期：2018-02-28 00:00:00

abstract：:Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a "high inflammatory/immune biotype." Recent studies implicate both complement and macrophages i...

journal_title：Frontiers in immunology

authors： Purves-Tyson TD,Robinson K,Brown AM,Boerrigter D,Cai HQ,Weissleder C,Owens SJ,Rothmond DA,Shannon Weickert C

更新日期：2020-09-29 00:00:00

abstract：:In the last two decades, extracellular vesicles (EVs) have aroused wide interest among researchers in basic and clinical research. EVs, small membrane vesicles are released by almost all kinds of cells into the extracellular environment. According to many recent studies, EVs participate in immunomodulation and play an...

journal_title：Frontiers in immunology

authors： Zhang B,Zhao M,Lu Q

更新日期：2021-01-14 00:00:00

abstract：:Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expressio...

journal_title：Frontiers in immunology

authors： Liu Y,Munker S,Müllenbach R,Weng HL

更新日期：2012-05-11 00:00:00

abstract：:Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ame...

journal_title：Frontiers in immunology

authors： Paivandy A,Sandelin M,Igelström H,Landelius P,Janson C,Melo FR,Pejler G

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

journal_title：Frontiers in immunology

authors： Katare PB,Bagul PK,Dinda AK,Banerjee SK

更新日期：2017-06-22 00:00:00