Abstract：
:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national level. In 135 NSTI patients and 65 control patients, admission levels of MASP-1, MASP-2, MASP-3, C4, C3, complement activation products C4c, C3bc, and terminal complement complex (TCC) were assessed. Results: The 90-day mortality was 23%. In a Cox regression model adjusted for sex, and SAPS II, a higher than median MASP-1 (HR 0.378, CI 95% [0.164-0.872], p = 0.0226) and C4 (HR 0.162, 95% CI [0.060-0.438], p = 0.0003), C4c/C4 ratio (HR 2.290 95% CI [1.078-4.867], p = 0.0312), C3bc (HR 2.664 95% CI [1.195-5.938], p = 0.0166), and C3bc/C3 ratio (HR 4.041 95% CI [1.673-9.758], p = 0.0019) were associated with 90-day mortality, while MASP-2, C4c, C3, and TCC were not. C4 had the highest ROC-AUC (0.748, [95% CI 0.649-0.847]), which was comparable to the AUC for SOFA score (0.753, [95% CI 0.649-0.857]), and SAPS II (0.862 [95% CI 0.795-0.929]). Conclusion: In adjusted analyses, high admission levels of the C4c/C4 ratio, C3bc, and the C3bc/C3 ratio were significantly associated with a higher risk of death after 90 days while high admission levels of MASP-1 and C4 were associated with lower risk. In this cohort, these variables are better predictors of mortality in NSTI than C-reactive protein and Procalcitonin. C4's ability to predict mortality was comparable to the well-established scoring systems SAPS score II and SOFA on day 1.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred Pdoi
10.3389/fimmu.2020.00017subject
Has Abstractpub_date
2020-01-31 00:00:00pages
17issn
1664-3224journal_volume
11pub_type
杂志文章abstract：:Ticks, blood-feeding arthropods, and secrete immunosuppressive molecules that inhibit host immune responses and provide survival advantages to pathogens. In this study, we characterized the immunosuppressive function of a novel tick salivary protein, DsCystatin, from Dermacentor silvarum of China. DsCystatin directly ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01245
更新日期：2018-06-01 00:00:00
abstract：:Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both physiological and pathological conditions. These structu...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.00826
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abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.01272
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abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01706
更新日期：2018-08-17 00:00:00
abstract：:Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2012.00161
更新日期：2012-06-18 00:00:00
abstract：:The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases. Some of them are primarily complement-mediated rare diseases, such as paroxysmal nocturnal hemoglobinuria, C3 glomerulonephritis, and a...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.01851
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abstract：:Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct "memory" states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2014.00680
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abstract：:Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.618402
更新日期：2021-01-08 00:00:00
abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2016.00239
更新日期：2016-06-14 00:00:00
abstract：:Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.01537
更新日期：2020-07-23 00:00:00
abstract：:NH36 is a vital enzyme of the DNA metabolism and a specific target for anti-Leishmania chemotherapy. We developed second-generation vaccines composed of the FML complex or its main native antigen, the NH36 nucleoside hydrolase of Leishmania (L.) donovani and saponin, and a DNA vaccine containing the NH36 gene. All the...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2019.00813
更新日期：2019-04-16 00:00:00
abstract：:Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we soug...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01374
更新日期：2019-06-14 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common path...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2015.00434
更新日期：2015-08-24 00:00:00
abstract：:CD4+ T cells play a central role in orchestrating protective immunity and autoimmunity. The activation and differentiation of myelin-reactive CD4+ T cells into effector (Th1 and Th17) and regulatory (Tregs) subsets at the peripheral tissues, and their subsequent transmigration across the blood-brain barrier (BBB) into...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.01695
更新日期：2017-11-29 00:00:00
abstract：:Background: Critically ill patients, especially following trauma or extensive surgery, experience a systemic immune response, consisting of a pro-inflammatory as well as a counterbalancing anti-inflammatory response. Pro-inflammation is necessary for the initiation of homeostatic control and wound healing of the organ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.00432
更新日期：2019-03-12 00:00:00
abstract：:Chronic lymphocytic leukemia (CLL) can be divided into prognostically distinct subsets with stereotyped or non-stereotyped, mutated or unmutated B cell receptors (BCRs). Individual subsets vary in antigen specificity and origin, but the impact of antigenic pressure on the CLL BCR repertoire remains unknown. Here, we e...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01996
更新日期：2018-09-13 00:00:00
abstract：:Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.02263
更新日期：2018-09-28 00:00:00
abstract：:Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of ot...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.02714
更新日期：2019-11-28 00:00:00
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pub_type： 杂志文章
doi：10.3389/fimmu.2018.03149
更新日期：2019-01-14 00:00:00
abstract：:Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2017.01846
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.01094
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2016.00183
更新日期：2016-05-19 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2019.00596
更新日期：2019-03-26 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2020.00676
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2014.00404
更新日期：2014-08-25 00:00:00
abstract：:Human regulatory CD4+ T cells (Tregs) are potent immunosuppressive lymphocytes responsible for immune tolerance and homeostasis. Since the seminal reports identifying Tregs, vast research has been channeled into understanding their genesis, signature molecular markers, mechanisms of suppression, and role in disease. T...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2017.01117
更新日期：2017-09-21 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2015.00627
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.574508
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01542
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.00592
更新日期：2018-03-22 00:00:00
