Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer.

abstract：:Accumulation of dendritic cells (DCs) is a special characteristic of the decidual microenvironment. Decidua-infiltrated DCs show unique phenotypes and functions that promote the establishment of fetal-maternal tolerance. However, the regulatory mechanisms yet to be fully investigated. Decidual stromal cells (DSCs) are...

journal_title：Frontiers in immunology

authors： Shao Q,Liu X,Huang Y,Chen X,Wang H

更新日期：2020-10-27 00:00:00

abstract：:NKG2D is a potent activating immunoreceptor expressed on nearly all cytotoxic lymphocytes promoting their cytotoxicity against self-cells expressing NKG2D ligands (NKG2DLs). NKG2DLs are MHC class I-like glycoproteins that usually are not expressed on "healthy" cells. Rather, their surface expression is induced by vari...

journal_title：Frontiers in immunology

authors： Kim Y,Born C,Bléry M,Steinle A

更新日期：2020-06-04 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement ...

journal_title：Frontiers in immunology

authors： Holers VM,Banda NK

更新日期：2018-05-28 00:00:00

abstract：:Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...

journal_title：Frontiers in immunology

authors： Huang G,Liu X,Duszynski DW,Tang X,El-Ashram S,Liu Z,Suo X,Li Q

更新日期：2017-12-18 00:00:00

abstract：:γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

journal_title：Frontiers in immunology

authors： Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

更新日期：2017-01-09 00:00:00

abstract：:Human papillomavirus (HPV) vaccines are safe and effective in preventing HPV infection and cervical precancers. Neutralizing antibodies are thought to be the primary mechanism of protection for HPV vaccines, although the exact level required for protection has not been identified. Three common serological assays used ...

journal_title：Frontiers in immunology

authors： Toh ZQ,He L,Chen C,Huang A,Russell FM,Garland SM,Reyburn R,Ratu T,Tuivaga E,Frazer IH,Mulholland EK,Licciardi PV

更新日期：2020-10-28 00:00:00

abstract：:Host immunity provides wide spectrum protection that serves to eradicate pathogens and cancer cells, while maintaining self-tolerance and immunological homeostasis. Ligation of the T cell receptor (TCR) by antigen activates signaling pathways that coordinately induce aerobic glycolysis, mitochondrial activity, anaboli...

journal_title：Frontiers in immunology

authors： Patsoukis N,Weaver JD,Strauss L,Herbel C,Seth P,Boussiotis VA

更新日期：2017-04-11 00:00:00

abstract：:Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different...

journal_title：Frontiers in immunology

authors： Bouvier I,Jusforgues-Saklani H,Lim A,Lemaître F,Lemercier B,Auriau C,Nicola MA,Leroy S,Law HK,Bandeira A,Moon JJ,Bousso P,Albert ML

更新日期：2011-12-08 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：PURPOSE OF REVIEW:The standard treatment options for systemic lupus erythematosus (SLE) are focused on non-specific immunosuppression. Over the past few years, scientific studies and ongoing clinical trials have shifted the paradigm with rapid advances in developing biologics and small molecules. A number of monoclonal...

journal_title：Frontiers in immunology

authors： Vukelic M,Li Y,Kyttaris VC

更新日期：2018-11-16 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is highly effective in the treatment of B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoma, providing alternative therapeutic options for patients who failed to respond to conventional treatment or relapse. Moreover, it can bridge other therapeutic strategies an...

journal_title：Frontiers in immunology

authors： Xu X,Sun Q,Liang X,Chen Z,Zhang X,Zhou X,Li M,Tu H,Liu Y,Tu S,Li Y

更新日期：2019-11-12 00:00:00

abstract：:Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish. In mammals, Dectin-1 is a member of the C-type lectin receptor (CLR) family a...

journal_title：Frontiers in immunology

authors： Petit J,Bailey EC,Wheeler RT,de Oliveira CAF,Forlenza M,Wiegertjes GF

更新日期：2019-02-26 00:00:00

abstract：:Chimeric antigen receptor (CAR) therapy has been proved effective in a stream of clinical trials, especially in hematologic malignancies. However, current CAR therapy is highly personalized as cells used are derived from patients themselves, which can be costly, time-consuming, and sometimes fails to achieve optimal t...

journal_title：Frontiers in immunology

authors： Zhang Y,Li P,Fang H,Wang G,Zeng X

更新日期：2020-12-10 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hBtk) display spontaneous ...

journal_title：Frontiers in immunology

authors： Rip J,de Bruijn MJW,Appelman MK,Pal Singh S,Hendriks RW,Corneth OBJ

更新日期：2019-01-30 00:00:00

abstract：:High aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most important products in nanotechnology. The wide range applications of ZnONWs have heightened the need for evaluating the risks and biological consequences to these particles. In this study, we investigated inflammatory pathways activated by ZnO...

journal_title：Frontiers in immunology

authors： Alghsham RS,Satpathy SR,Bodduluri SR,Hegde B,Jala VR,Twal W,Burlison JA,Sunkara M,Haribabu B

更新日期：2019-11-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.00367.]. ...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-04-03 00:00:00

abstract：:HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology, and response to antiretroviral treatment - and how best to monitor them - remain unclear. We develop a quantitative high-throughput sequencing ...

journal_title：Frontiers in immunology

authors： Heather JM,Best K,Oakes T,Gray ER,Roe JK,Thomas N,Friedman N,Noursadeghi M,Chain B

更新日期：2016-01-11 00:00:00

abstract：:The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto unknown clinical sig...

journal_title：Frontiers in immunology

authors： Bergström B,Lundqvist C,Vasileiadis GK,Carlsten H,Ekwall O,Ekwall AH

更新日期：2019-06-18 00:00:00

abstract：:The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...

journal_title：Frontiers in immunology

authors： Dupré L,Houmadi R,Tang C,Rey-Barroso J

更新日期：2015-11-18 00:00:00

abstract：:Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is stochastically established, KIR repertoire perturbations reflect a dominance of discrete NK-cell subsets as the conse...

journal_title：Frontiers in immunology

authors： Zambello R,Teramo A,Barilà G,Gattazzo C,Semenzato G

更新日期：2014-02-26 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：Background:The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods:This was a single ...

journal_title：Frontiers in immunology

authors： Spinella PC,Thomas KA,Turnbull IR,Fuchs A,Bochicchio K,Schuerer D,Reese S,Coleoglou Centeno AA,Horn CB,Baty J,Shea SM,Meledeo MA,Pusateri AE,Levy JH,Cap AP,Bochicchio GV,TAMPITI Investigators.

更新日期：2020-09-08 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00

abstract：:The global health burden associated with melanoma continues to increase while treatment options for metastatic melanoma are limited. Nevertheless, in the past decade, the field of cancer immunotherapy has witnessed remarkable advances for the treatment of a number of malignancies including metastatic melanoma. Althoug...

journal_title：Frontiers in immunology

authors： Sadozai H,Gruber T,Hunger RE,Schenk M

更新日期：2017-12-08 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques. Sufficient clearance of myelin and cellular debris is one of the requirements for proper tissue repair and remyelination. The mechanisms underlying the clearance o...

journal_title：Frontiers in immunology

authors： Kamermans A,Rijnsburger M,Chakraborty A,van der Pol S,de Vries HE,van Horssen J

更新日期：2019-05-03 00:00:00

abstract：:Considerable evidence has been gathered over the last 10 years showing that the tumor microenvironment (TME) is not simply a passive recipient of immune cells, but an active participant in the establishment of immunosuppressive conditions. It is now well documented that hypoxia, within the TME, affects the functions o...

journal_title：Frontiers in immunology

authors： Baginska J,Viry E,Paggetti J,Medves S,Berchem G,Moussay E,Janji B

更新日期：2013-12-25 00:00:00

abstract：:The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Smolen KK,Willems F,Kollmann TR,Marchant A

更新日期：2016-08-31 00:00:00

abstract：:Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

journal_title：Frontiers in immunology

authors： Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

更新日期：2020-02-14 00:00:00