The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response.

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

journal_title：Frontiers in immunology

authors： Meli R,Mattace Raso G,Calignano A

更新日期：2014-04-23 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-s...

journal_title：Frontiers in immunology

authors： Ashley CL,Abendroth A,McSharry BP,Slobedman B

更新日期：2019-12-11 00:00:00

abstract：:Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Eston...

journal_title：Frontiers in immunology

authors： Ruohtula T,de Goffau MC,Nieminen JK,Honkanen J,Siljander H,Hämäläinen AM,Peet A,Tillmann V,Ilonen J,Niemelä O,Welling GW,Knip M,Harmsen HJ,Vaarala O

更新日期：2019-10-23 00:00:00

abstract：:In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing...

journal_title：Frontiers in immunology

authors： Maueröder C,Mahajan A,Paulus S,Gößwein S,Hahn J,Kienhöfer D,Biermann MH,Tripal P,Friedrich RP,Munoz LE,Neurath MF,Becker C,Schett GA,Herrmann M,Leppkes M

更新日期：2016-12-09 00:00:00

abstract：:Sepsis is characterized by the host's dysregulated immune response to an infection followed by a potentially fatal organ dysfunction. Although there have been some advances in the treatment of sepsis, mainly focused on broad-spectrum antibiotics, mortality rates remain high, urging for the search of new therapies. Oxi...

journal_title：Frontiers in immunology

authors： Navegantes-Lima KC,Monteiro VVS,de França Gaspar SL,de Brito Oliveira AL,de Oliveira JP,Reis JF,de Souza Gomes R,Rodrigues CA,Stutz H,Sovrani V,Peres A,Romão PRT,Monteiro MC

更新日期：2020-07-01 00:00:00

abstract：:Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the reso...

journal_title：Frontiers in immunology

authors： Barnig C,Bezema T,Calder PC,Charloux A,Frossard N,Garssen J,Haworth O,Dilevskaya K,Levi-Schaffer F,Lonsdorfer E,Wauben M,Kraneveld AD,Te Velde AA

更新日期：2019-07-23 00:00:00

abstract：:The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epito...

journal_title：Frontiers in immunology

authors： Gupta S,Agarwal A,Kumar A,Biswas D

更新日期：2018-04-10 00:00:00

abstract：:The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises ...

journal_title：Frontiers in immunology

authors： Sciumè G,Shih HY,Mikami Y,O'Shea JJ

更新日期：2017-11-13 00:00:00

abstract：:Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

journal_title：Frontiers in immunology

authors： Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

更新日期：2018-01-31 00:00:00

abstract：:Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

journal_title：Frontiers in immunology

authors： Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

更新日期：2018-05-29 00:00:00

abstract：:Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings, where the conventional parasitological methods are insensitive. We determined the accuracy of an up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay in urine and serum for...

journal_title：Frontiers in immunology

authors： Sousa MS,van Dam GJ,Pinheiro MCC,de Dood CJ,Peralta JM,Peralta RHS,Daher EF,Corstjens PLAM,Bezerra FSM

更新日期：2019-04-04 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which is different from linear RNA. CircRNA is an RNA molecule with a closed loop structure formed by reverse splicing. CircRNAs have been studied in several organisms, however, the circRNAs associated with the response to Salmonella enterica serovar En...

journal_title：Frontiers in immunology

authors： Zheng L,Liu L,Lin L,Tang H,Fan X,Lin H,Li X

更新日期：2019-05-31 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial encroachment. In addition to their antimicrobial activities, defensins in general, and human β-defensin 2 (hBD2) in particular, also exhibit immunomodulatory ca...

journal_title：Frontiers in immunology

authors： Koeninger L,Armbruster NS,Brinch KS,Kjaerulf S,Andersen B,Langnau C,Autenrieth SE,Schneidawind D,Stange EF,Malek NP,Nordkild P,Jensen BAH,Wehkamp J

更新日期：2020-01-31 00:00:00

abstract：:The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers ...

journal_title：Frontiers in immunology

authors： Bürckert JP,Dubois ARSX,Faison WJ,Farinelle S,Charpentier E,Sinner R,Wienecke-Baldacchino A,Muller CP

更新日期：2017-12-22 00:00:00

abstract：:Chemokines and their cognate receptors have been identified as major factors initiating and governing cell movement and interaction. These ligands and their receptors are expressed on a wide variety of cells and act during steady-state migration as well as inflammatory recruitment. CCR6 is a non-promiscuous chemokine ...

journal_title：Frontiers in immunology

authors： Lee AY,Eri R,Lyons AB,Grimm MC,Korner H

更新日期：2013-07-15 00:00:00

abstract：:Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR) repertoires through next-generation sequencing is providing excellent insights into the understanding of adaptive immune responses. Variable(Diversity)Joining [V(D)J] germline genes and alleles must be characterized in detail to fac...

journal_title：Frontiers in immunology

authors： Zhang W,Wang IM,Wang C,Lin L,Chai X,Wu J,Bett AJ,Dhanasekaran G,Casimiro DR,Liu X

更新日期：2016-11-04 00:00:00

abstract：:The emergence and continuous development of immune checkpoint inhibitors (ICIs) therapy brings a revolution in cancer therapy history, but the major hurdle associated with their usage is the concomitant ICIs-related toxicities that present a challenge for oncologists. The toxicities may involve non-specific symptoms o...

journal_title：Frontiers in immunology

authors： Xu Y,Fu Y,Zhu B,Wang J,Zhang B

更新日期：2020-10-06 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide. Efforts to develop a next-generation vaccine have largely focused on envelope glycoproteins to target virus-neutralizing antibody responses. However, these approach...

journal_title：Frontiers in immunology

authors： Mokhtar H,Pedrera M,Frossard JP,Biffar L,Hammer SE,Kvisgaard LK,Larsen LE,Stewart GR,Somavarapu S,Steinbach F,Graham SP

更新日期：2016-02-16 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

journal_title：Frontiers in immunology

authors： Jacquet S,Pontier D,Etienne L

更新日期：2020-12-18 00:00:00

abstract：:Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE-/-) mice. Male ApoE-/- mice received vehicle (control), low-level lipopolysaccharide (...

journal_title：Frontiers in immunology

authors： Chami B,Hossain F,Hambly TW,Cai X,Aran R,Fong G,Vellajo A,Martin NJJ,Wang X,Dennis JM,Sharma A,Shihata WA,Chin-Dusting JPF,de Haan JB,Sharland A,Geczy CL,Freedman B,Witting PK

更新日期：2019-03-07 00:00:00

abstract：:HERV-H endogenous retroviruses are thought to be essential to stem cell identity in humans. We embrace several decades of HERV-H research in order to relate the transcription of HERV-H loci to their genomic structure. We find that highly transcribed HERV-H loci are younger, more fragmented, and less likely to be prese...

journal_title：Frontiers in immunology

authors： Gemmell P,Hein J,Katzourakis A

更新日期：2019-07-09 00:00:00

abstract：:Aging is a continuous process promoted by both intrinsic and extrinsic factors that each trigger a multitude of molecular events. Increasing evidence supports a central role for inflammation in this progression. Here, we discuss how the low-grade chronic inflammation that characterizes aging is tightly interconnected ...

journal_title：Frontiers in immunology

authors： Pinheiro da Silva F,Machado MCC

更新日期：2017-10-25 00:00:00

abstract：:Piperlongumine (PL), a natural small molecule derived from the Piper longum Linn plant, has received growing interest as a prooxidative drug with promising anticancer properties. Yet, the influence of PL on primary human T cells remained elusive. Knowledge of this is of crucial importance, however, since T cells in pa...

journal_title：Frontiers in immunology

authors： Liang J,Ziegler JD,Jahraus B,Orlik C,Blatnik R,Blank N,Niesler B,Wabnitz G,Ruppert T,Hübner K,Balta E,Samstag Y

更新日期：2020-06-12 00:00:00

abstract：:The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly virulent in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of...

journal_title：Frontiers in immunology

authors： Reche PA

更新日期：2020-10-16 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Richter's syndrome), ...

journal_title：Frontiers in immunology

authors： Märklin M,Fuchs AR,Tandler C,Heitmann JS,Salih HR,Kauer J,Quintanilla-Martinez L,Wirths S,Kopp HG,Müller MR

更新日期：2020-09-02 00:00:00

abstract：:Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

journal_title：Frontiers in immunology

authors： Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

更新日期：2019-06-25 00:00:00