The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances.

abstract：:Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...

journal_title：Frontiers in immunology

authors： Turner JS,Day A,Alsoussi WB,Liu Z,O'Halloran JA,Presti RM,Patterson BK,Whelan SPJ,Ellebedy AH,Mudd PA

更新日期：2021-01-08 00:00:00

abstract：:The close association between cardiovascular pathology and renal dysfunction is well documented and significant. Patients with conventional risk factors for cardiovascular disease like diabetes and hypertension also suffer renal dysfunction. This is unsurprising if the kidney is simply regarded as a "modified blood ve...

journal_title：Frontiers in immunology

authors： Hewitson TD,Holt SG,Smith ER

更新日期：2015-09-17 00:00:00

abstract：PURPOSE OF REVIEW:The standard treatment options for systemic lupus erythematosus (SLE) are focused on non-specific immunosuppression. Over the past few years, scientific studies and ongoing clinical trials have shifted the paradigm with rapid advances in developing biologics and small molecules. A number of monoclonal...

journal_title：Frontiers in immunology

authors： Vukelic M,Li Y,Kyttaris VC

更新日期：2018-11-16 00:00:00

abstract：:Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even formation of non-union. However, immuno-senescence is not limited to the adaptive ...

journal_title：Frontiers in immunology

authors： Löffler J,Sass FA,Filter S,Rose A,Ellinghaus A,Duda GN,Dienelt A

更新日期：2019-10-18 00:00:00

abstract：:Antibodies against HLA and non-HLA are associated with transplantation outcome. Recently, pretransplant serum IgG antibody levels against apoptotic cells were found to correlate with kidney allograft loss. We investigated the presence of these antibodies in lung transplantation (LTx) patients and evaluated the correla...

journal_title：Frontiers in immunology

authors： Budding K,van de Graaf EA,Kardol-Hoefnagel T,Oudijk ED,Kwakkel-van Erp JM,Hack CE,Otten HG

更新日期：2017-03-21 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammation have been incompletely described. In this study, we investigated GP...

journal_title：Frontiers in immunology

authors： Recio C,Lucy D,Purvis GSD,Iveson P,Zeboudj L,Iqbal AJ,Lin D,O'Callaghan C,Davison L,Griesbach E,Russell AJ,Wynne GM,Dib L,Monaco C,Greaves DR

更新日期：2018-06-20 00:00:00

abstract：:Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the...

journal_title：Frontiers in immunology

authors： Terrén I,Orrantia A,Vitallé J,Zenarruzabeitia O,Borrego F

更新日期：2019-09-24 00:00:00

abstract：:Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tis...

journal_title：Frontiers in immunology

authors： Wu Y,Tian Z,Wei H

更新日期：2017-08-04 00:00:00

abstract：:There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

journal_title：Frontiers in immunology

authors： Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

更新日期：2019-04-05 00:00:00

abstract：:The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close ...

journal_title：Frontiers in immunology

authors： Rosales-Mendoza S,Nieto-Gómez R,Angulo C

更新日期：2017-03-10 00:00:00

abstract：:Background: Apart from IgG oligoclonal bands, no other biomarker has, to date, been validated for diagnostic and/or prognostic purposes in multiple sclerosis (MS). Aim: To investigate a wide panel of cytokines and chemokines in the cerebrospinal fluid (CSF) of relapsing-remitting MS (RRMS) patients and evaluate their ...

journal_title：Frontiers in immunology

authors： Puthenparampil M,Stropparo E,Zywicki S,Bovis F,Cazzola C,Federle L,Grassivaro F,Rinaldi F,Perini P,Sormani MP,Gallo P

更新日期：2020-03-05 00:00:00

abstract：Background:Ischemia-reperfusion (IR) is a major contributor to graft rejection after liver transplantation. During IR injury, an intense inflammatory process occurs in the liver. Neutrophils are considered central players in the events that lead to liver injury. CXC chemokines mediate hepatic inflammation following rep...

journal_title：Frontiers in immunology

authors： de Oliveira THC,Marques PE,Poosti F,Ruytinx P,Amaral FA,Brandolini L,Allegretti M,Proost P,Teixeira MM

更新日期：2018-01-05 00:00:00

abstract：:Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

journal_title：Frontiers in immunology

authors： Zwaini Z,Alammari D,Byrne S,Stover C

更新日期：2016-03-30 00:00:00

abstract：:Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells. ILCs are present in lymphoid and non-lympho...

journal_title：Frontiers in immunology

authors： Panda SK,Colonna M

更新日期：2019-05-07 00:00:00

abstract：:Background: IL-17A has effects on several cell types and is a therapeutic target in several inflammatory diseases. IL-17F shares 50% homology and biological activities with IL-17A. It is now of interest to target both cytokines. The objective was to compare the IL-17A and IL-17F effect on cytokine production by RA syn...

journal_title：Frontiers in immunology

authors： Noack M,Beringer A,Miossec P

更新日期：2019-07-23 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00

abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...

journal_title：Frontiers in immunology

authors： Nicoli F,Papagno L,Frere JJ,Cabral-Piccin MP,Clave E,Gostick E,Toubert A,Price DA,Caputo A,Appay V

更新日期：2018-12-21 00:00:00

abstract：:A sudden outbreak of COVID-19 caused by a novel coronavirus, SARS-CoV-2, in Wuhan, China in December 2019 quickly grew into a global pandemic, putting at risk not only the global healthcare system, but also the world economy. As the disease continues to spread rapidly, the development of prophylactic and therapeutic a...

journal_title：Frontiers in immunology

authors： Liang Y,Wang ML,Chien CS,Yarmishyn AA,Yang YP,Lai WY,Luo YH,Lin YT,Chen YJ,Chang PC,Chiou SH

更新日期：2020-05-12 00:00:00

abstract：:Objectives: Standardization of myositis specific antibody (MSA) detection is of high importance because these antibodies are relevant for diagnosis and stratification of patients with idiopathic inflammatory myositis (IIM) and have the potential to be used in classification criteria. Many laboratories rely on immunopr...

journal_title：Frontiers in immunology

authors： Mahler M,Betteridge Z,Bentow C,Richards M,Seaman A,Chinoy H,McHugh N

更新日期：2019-04-30 00:00:00

abstract：:Dengue is considered the most important emerging, human arboviruses, with worldwide distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or specific anti-viral drugs. The development of a dengue vaccine faces unique challenges. The four serotypes co-circulate in endemic areas, an...

journal_title：Frontiers in immunology

authors： Sariol CA,White LJ

更新日期：2014-09-24 00:00:00

abstract：:The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers ...

journal_title：Frontiers in immunology

authors： Bürckert JP,Dubois ARSX,Faison WJ,Farinelle S,Charpentier E,Sinner R,Wienecke-Baldacchino A,Muller CP

更新日期：2017-12-22 00:00:00

abstract：:Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent immune responses is n...

journal_title：Frontiers in immunology

authors： Aragoneses-Fenoll L,Ojeda G,Montes-Casado M,Acosta-Ampudia Y,Dianzani U,Portolés P,Rojo JM

更新日期：2018-02-27 00:00:00

abstract：:Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish. In mammals, Dectin-1 is a member of the C-type lectin receptor (CLR) family a...

journal_title：Frontiers in immunology

authors： Petit J,Bailey EC,Wheeler RT,de Oliveira CAF,Forlenza M,Wiegertjes GF

更新日期：2019-02-26 00:00:00

abstract：:Background: Critically ill patients, especially following trauma or extensive surgery, experience a systemic immune response, consisting of a pro-inflammatory as well as a counterbalancing anti-inflammatory response. Pro-inflammation is necessary for the initiation of homeostatic control and wound healing of the organ...

journal_title：Frontiers in immunology

authors： Tamulyte S,Kopplin J,Brenner T,Weigand MA,Uhle F

更新日期：2019-03-12 00:00:00

abstract：:T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and o...

journal_title：Frontiers in immunology

authors： Hale JS,Ahmed R

更新日期：2015-02-02 00:00:00

abstract：:Highly sensitive reporter-gene assays have been developed that allow both the direct vascular endothelial growth factor (VEGF) neutralizing activity of bevacizumab and the ability of bevacizumab to activate antibody dependent cellular cytotoxicity (ADCC) to be quantified rapidly and in a highly specific manner. The us...

journal_title：Frontiers in immunology

authors： Lallemand C,Ferrando-Miguel R,Auer M,Iglseder S,Czech T,Gaber-Wagener A,Di Pauli F,Deisenhammer F,Tovey MG

更新日期：2020-10-15 00:00:00

abstract：:We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice. Although the protective effects were ascribed to the induction of ad...

journal_title：Frontiers in immunology

authors： Horwitz DA,Liu A,Bickerton S,Castaldo G,Matarese G,Fahmy TM,La Cava A

更新日期：2020-12-16 00:00:00

abstract：:Cerebral malaria is a life-threatening complication of malaria in humans, and the underlying pathogenic mechanisms are widely analyzed in a murine model of experimental cerebral malaria (ECM). Here, we show abrogation of ECM by hemocoel sporozoite-induced infection of a transgenic Plasmodium berghei line that overexpr...

journal_title：Frontiers in immunology

authors： Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K

更新日期：2019-11-01 00:00:00

abstract：Background:The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods:This was a single ...

journal_title：Frontiers in immunology

authors： Spinella PC,Thomas KA,Turnbull IR,Fuchs A,Bochicchio K,Schuerer D,Reese S,Coleoglou Centeno AA,Horn CB,Baty J,Shea SM,Meledeo MA,Pusateri AE,Levy JH,Cap AP,Bochicchio GV,TAMPITI Investigators.

更新日期：2020-09-08 00:00:00