Abstract:
:The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close to being commercialized. Although plant-based antibodies against EBOV are under clinical evaluation, the development of plant-based vaccines against EBOV essentially remains an unexplored area. The current technologies for the production of plant-based vaccines include stable nuclear expression, transient expression mediated by viral vectors, and chloroplast expression. Specific perspectives on how these technologies can be applied for developing anti-EBOV vaccines are provided, including possibilities for the design of immunogens as well as the potential of the distinct expression modalities to produce the most relevant EBOV antigens in plants considering yields, posttranslational modifications, production time, and downstream processing.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Rosales-Mendoza S,Nieto-Gómez R,Angulo Cdoi
10.3389/fimmu.2017.00252subject
Has Abstractpub_date
2017-03-10 00:00:00pages
252issn
1664-3224journal_volume
8pub_type
杂志文章,评审abstract::In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules. There are three major functionally distinct effector states for iNKT cells. Owning to these innate-like effector...
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pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
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abstract::[This corrects the article DOI: 10.3389/fimmu.2018.00707.]. ...
journal_title:Frontiers in immunology
pub_type: 杂志文章,已发布勘误
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更新日期:2018-09-27 00:00:00
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