Abstract:
:Re-directing T cells via chimeric antigen receptors (CARs) was first tested in HIV-infected individuals with limited success, but these pioneering studies laid the groundwork for the clinically successful CD19 CARs that were recently FDA approved. Now there is great interest in revisiting the concept of using CAR-expressing T cells as part of a strategy to cure HIV. Many lessons have been learned on how to best engineer T cells to cure cancer, but not all of these lessons apply when developing CARs to treat and cure HIV. This mini review will focus on how early CAR T cell studies in HIV paved the way for cancer CAR T cell therapy and how progress in cancer CAR therapy has and will continue to be instructive for the development of HIV CAR T cell therapy. Additionally, the unique challenges that must be overcome to develop a successful HIV CAR T cell therapy will be highlighted.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Kim GB,Hege K,Riley JLdoi
10.3389/fimmu.2019.02310subject
Has Abstractpub_date
2019-09-27 00:00:00pages
2310issn
1664-3224journal_volume
10pub_type
杂志文章,评审abstract::[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.]. ...
journal_title:Frontiers in immunology
pub_type: 杂志文章,已发布勘误
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abstract::Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct "memory" states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging...
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2017.00201
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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更新日期:2019-09-27 00:00:00
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journal_title:Frontiers in immunology
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pub_type: 杂志文章,评审
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更新日期:2019-11-21 00:00:00