Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments.

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently treated with trastuzumab (Herceptin) and bevacizumab (Avastin), res...

journal_title：Frontiers in immunology

authors： Corraliza-Gorjón I,Somovilla-Crespo B,Santamaria S,Garcia-Sanz JA,Kremer L

更新日期：2017-12-21 00:00:00

abstract：:This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that t...

journal_title：Frontiers in immunology

authors： Machelart A,Van Vyve M,Potemberg G,Demars A,De Trez C,Tima HG,Vanwalleghem G,Romano M,Truyens C,Letesson JJ,Muraille E

更新日期：2017-07-31 00:00:00

abstract：:Chronic periodontitis is an inflammatory disease caused by the formation of oral microbial biofilms. Periodontitis is associated with general health and not only oral diseases. Porphyromonas gingivalis is a well-known keystone pathogen for periodontitis and is associated with several systemic diseases, such as diabete...

journal_title：Frontiers in immunology

authors： Hirai K,Yamaguchi-Tomikawa T,Eguchi T,Maeda H,Takashiba S

更新日期：2020-06-05 00:00:00

abstract：:Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that ...

journal_title：Frontiers in immunology

authors： Mesman AW,Geijtenbeek TB

更新日期：2012-03-26 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated retrovirus (MSRV), a member of HERV-W family and...

journal_title：Frontiers in immunology

authors： Charvet B,Reynaud JM,Gourru-Lesimple G,Perron H,Marche PN,Horvat B

更新日期：2018-12-06 00:00:00

abstract：:The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

journal_title：Frontiers in immunology

authors： Cong J,Wei H

更新日期：2019-06-25 00:00:00

abstract：:Recent events have made it clear that potentially pandemic strains of influenza regularly pose a threat to human populations. Therefore, it is essential that we develop better strategies to enhance vaccine design and evaluation to predict those that will be poor responders to vaccination and to identify those that are...

journal_title：Frontiers in immunology

authors： DiPiazza A,Richards KA,Knowlden ZA,Nayak JL,Sant AJ

更新日期：2016-01-25 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

journal_title：Frontiers in immunology

authors： Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

更新日期：2020-01-21 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire. In this paper, we enrich these...

journal_title：Frontiers in immunology

authors： Krawczyk K,Kelm S,Kovaltsuk A,Galson JD,Kelly D,Trück J,Regep C,Leem J,Wong WK,Nowak J,Snowden J,Wright M,Starkie L,Scott-Tucker A,Shi J,Deane CM

更新日期：2018-07-23 00:00:00

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：:Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the vector to commonly used antimalarial drugs and insecticides, res...

journal_title：Frontiers in immunology

authors： Kengne-Ouafo JA,Sutherland CJ,Binka FN,Awandare GA,Urban BC,Dinko B

更新日期：2019-02-11 00:00:00

abstract：:Immunotherapy using checkpoint blockade has revolutionized cancer treatment, improving patient survival and quality of life. Nevertheless, the clinical outcomes of such immunotherapy are highly heterogeneous between patients. Depending on the cancer type, the patient response rates to this immunotherapy are limited to...

journal_title：Frontiers in immunology

authors： Chuang YC,Tseng JC,Huang LR,Huang CM,Huang CF,Chuang TH

更新日期：2020-05-29 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to fight against pathogen infection and tumors. Because of their abilit...

journal_title：Frontiers in immunology

authors： Takami M,Ihara F,Motohashi S

更新日期：2018-09-07 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading to disability in young adults. The outcome of the disease is unpredictable, and over time, neurological disabilities accumulate. Interferon beta-1b was the first drug to be approved in the 1990s for relapsing-remitting MS to modula...

journal_title：Frontiers in immunology

authors： Rommer PS,Milo R,Han MH,Satyanarayan S,Sellner J,Hauer L,Illes Z,Warnke C,Laurent S,Weber MS,Zhang Y,Stuve O

更新日期：2019-07-11 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth fa...

journal_title：Frontiers in immunology

authors： Foster SL,Seehus CR,Woolf CJ,Talbot S

更新日期：2017-11-03 00:00:00

abstract：:The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect ...

journal_title：Frontiers in immunology

authors： Elias-Oliveira J,Leite JA,Pereira ÍS,Guimarães JB,Manso GMDC,Silva JS,Tostes RC,Carlos D

更新日期：2020-08-11 00:00:00

abstract：:An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a ...

journal_title：Frontiers in immunology

authors： Fazilleau N,Aloulou M

更新日期：2018-08-13 00:00:00

abstract：:Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a l...

journal_title：Frontiers in immunology

authors： Bonacini M,Soriano A,Zerbini A,Calò E,Cimino L,Muratore F,Fontana L,Braglia L,Parmeggiani M,Salvarani C,Croci S

更新日期：2018-09-25 00:00:00

abstract：:Responsiveness of maturing natural killer (NK) cells to chemotactic molecules directly affect their retention and relocation in selected bone marrow (BM) microenvironment during development, as well as their localization at sites of immune response during inflammatory diseases. BM is the main site of NK cell generatio...

journal_title：Frontiers in immunology

authors： Bernardini G,Sciumè G,Santoni A

更新日期：2013-01-30 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene therapy and, recently, to the market approval of an AAV-based drug in Europe. With...

journal_title：Frontiers in immunology

authors： Basner-Tschakarjan E,Mingozzi F

更新日期：2014-07-23 00:00:00