Developmental and Functional Control of Natural Killer Cells by Cytokines.


:Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tissues. The development and functions of such NK cells are controlled by various cytokines, such as fms-like tyrosine kinase 3 ligand (FL), kit ligand (KL), interleukin (IL)-3, IL-10, IL-12, IL-18, transforming growth factor-β, and common-γ chain family cytokines, which operate at different stages by regulating distinct signaling pathways. Nevertheless, the specific roles of each cytokine that regulates NK cell development or that shapes different NK cell functions remain unclear. In this review, we attempt to describe the characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells. A comprehensive understanding of the role of cytokines in NK cell development and function will aid the generation of better efficacy for adoptive NK cell treatment.


Front Immunol


Frontiers in immunology


Wu Y,Tian Z,Wei H




Has Abstract


2017-08-04 00:00:00








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    更新日期:2018-07-25 00:00:00

  • Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.

    abstract::Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like activities may nee...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhao Y,Tahiliani V,Salek-Ardakani S,Croft M

    更新日期:2012-11-08 00:00:00

  • Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.

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    authors: Nde PN,Lima MF,Johnson CA,Pratap S,Villalta F

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  • The role of Peyer's patches in synchronizing gut IgA responses.

    abstract::Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lycke NY,Bemark M

    更新日期:2012-11-07 00:00:00

  • MicroRNA-Mediated Control of Inflammation and Tolerance in Pregnancy.

    abstract::Gestational age-dependent immune intolerance at the maternal-fetal interface might be a contributing factor to placental pathology and adverse pregnancy outcomes. Although the intrauterine setting is highly choreographed and considered to be a protective environment for the fetus, unscheduled inflammation might overwh...

    journal_title:Frontiers in immunology

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    authors: Kamity R,Sharma S,Hanna N

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    authors: Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

    更新日期:2020-10-23 00:00:00

  • TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity.

    abstract::An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Roselli E,Araya P,Núñez NG,Gatti G,Graziano F,Sedlik C,Benaroch P,Piaggio E,Maccioni M

    更新日期:2019-03-20 00:00:00

  • Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila.

    abstract::Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae. Over the last deca...

    journal_title:Frontiers in immunology

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    authors: Davoodi S,Foley E

    更新日期:2020-01-24 00:00:00

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    authors: Abreu-Filho PG,Tarragô AM,Costa AG,Monteiro WM,Meielles AFG,Costa TCC,Silva JS,Zambuzi FA,Gardinassi LG,Moraes LAB,Lacerda MVG,Sorgi CA,Faccioli LH,Malheiro A

    更新日期:2019-09-18 00:00:00

  • l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes.

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    authors: Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

    更新日期:2017-04-25 00:00:00

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    abstract::The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to generate cross-reactive...

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    authors: Sato-Kaneko F,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Cottam HB,Chan M,Chu PJ,Burkhart D,Schoener R,Matsutani T,Carson DA,Corr M,Hayashi T

    更新日期:2020-06-19 00:00:00

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    authors: Yoo EJ,Lee HH,Ye BJ,Lee JH,Lee CY,Kang HJ,Jeong GW,Park H,Lim SW,Lee-Kwon W,Kwon HM,Choi SY

    更新日期:2019-04-18 00:00:00

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    authors: Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HR

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    authors: Roberts CA,Dickinson AK,Taams LS

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    abstract::Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion ...

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    authors: Darweesh M,Kamel W,Gavrilin MA,Akusjärvi G,Svensson C

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    authors: Chen Y,Huang H,He Y,Chen M,Seidler U,Tian D,Xiao F

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    abstract::Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

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    更新日期:2019-03-11 00:00:00

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    authors: Sousa MS,van Dam GJ,Pinheiro MCC,de Dood CJ,Peralta JM,Peralta RHS,Daher EF,Corstjens PLAM,Bezerra FSM

    更新日期:2019-04-04 00:00:00

  • Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis.

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    authors: Ndlovu H,Marakalala MJ

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    authors: Li Z,Ju X,Silveira PA,Abadir E,Hsu WH,Hart DNJ,Clark GJ

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    authors: Läubli H,Borsig L

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    authors: Palatnik-de-Sousa CB

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    abstract::A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein....

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    authors: Cong J,Wei H

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    authors: Danger R,Chesneau M,Delbos F,Le Bot S,Kerleau C,Chenouard A,Ville S,Degauque N,Conchon S,Cesbron A,Giral M,Brouard S

    更新日期:2019-09-10 00:00:00

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    authors: Vaes B,Van't Hof W,Deans R,Pinxteren J

    更新日期:2012-11-27 00:00:00

  • Sex Bias in Asthma Prevalence and Pathogenesis.

    abstract::Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, im...

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    pub_type: 杂志文章,评审


    authors: Shah R,Newcomb DC

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