Developmental and Functional Control of Natural Killer Cells by Cytokines.

abstract：:Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the...

journal_title：Frontiers in immunology

authors： Terrén I,Orrantia A,Vitallé J,Zenarruzabeitia O,Borrego F

更新日期：2019-09-24 00:00:00

abstract：Background:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading worldwide. Measuring the prevention and control of the disease has become a matter requiring urgent focus. Objective:Based on coronavirus disease 2019 (COVID-19) clinical data from Wuhan, we conducted an in-depth analysis to...

journal_title：Frontiers in immunology

authors： Qun S,Wang Y,Chen J,Huang X,Guo H,Lu Z,Wang J,Zheng C,Ma Y,Zhu Y,Xia D,Wang Y,He H,Wang Y,Fei M,Yin Y,Zheng M,Xu Y,Ge W,Hu F,Zhou J

更新日期：2020-09-02 00:00:00

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene therapy and, recently, to the market approval of an AAV-based drug in Europe. With...

journal_title：Frontiers in immunology

authors： Basner-Tschakarjan E,Mingozzi F

更新日期：2014-07-23 00:00:00

abstract：:Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in terms of gene expres...

journal_title：Frontiers in immunology

authors： García-González PA,Schinnerling K,Sepúlveda-Gutiérrez A,Maggi J,Hoyos L,Morales RA,Mehdi AM,Nel HJ,Soto L,Pesce B,Molina MC,Cuchacovich M,Larrondo ML,Neira Ó,Catalán DF,Hilkens CM,Thomas R,Verdugo RA,Aguillón JC

更新日期：2016-10-25 00:00:00

abstract：:T cells recognizing epitopes on the surface of mycobacteria-infected macrophages can impart protection, but with associated risk for reactivation to lung pathology. We aimed to identify antibodies specific to such epitopes, which carry potentials for development toward novel therapeutic constructs. Since epitopes pres...

journal_title：Frontiers in immunology

authors： Ortega PA,Silva-Miranda M,Torres-Larios A,Campos-Chávez E,Franken KCLCM,Ottenhoff THM,Ivanyi J,Espitia C

更新日期：2020-10-02 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airway. Its major symptoms are reversible breathing problems causing airway narrowing and obstruction. IL-19 is a member of the IL-10 family cytokines. We previously showed that IL-19 induces T-helper 2 (Th2) cytokines and that asthma patients had higher serum IL-19 leve...

journal_title：Frontiers in immunology

authors： Weng YH,Chen WY,Lin YL,Wang JY,Chang MS

更新日期：2019-04-30 00:00:00

abstract：:Chimeric Antigen Receptor (CAR) T cells expressing the fusion of the NKG2D protein with CD3ζ (NKG2D-CAR T Cells) acquire a specificity for stress-induced ligands expressed on hematological and solid cancers. However, these stress ligands are also transiently expressed by activated T cells implying that NKG2D-based T c...

journal_title：Frontiers in immunology

authors： Breman E,Demoulin B,Agaugué S,Mauën S,Michaux A,Springuel L,Houssa J,Huberty F,Jacques-Hespel C,Marchand C,Marijsse J,Nguyen T,Ramelot N,Violle B,Daro D,De Waele P,Gilham DE,Steenwinckel V

更新日期：2018-12-12 00:00:00

abstract：:Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an "alarmin" role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cell...

journal_title：Frontiers in immunology

authors： Li L,Zhu H,Zuo X

更新日期：2018-11-15 00:00:00

abstract：:Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

journal_title：Frontiers in immunology

authors： Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

更新日期：2019-08-08 00:00:00

abstract：:Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was ...

journal_title：Frontiers in immunology

authors： Toor SM,Syed Khaja AS,El Salhat H,Bekdache O,Kanbar J,Jaloudi M,Elkord E

更新日期：2016-12-08 00:00:00

abstract：:Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects of single supply or...

journal_title：Frontiers in immunology

authors： Nhu TQ,Bich Hang BT,Cornet V,Oger M,Bach LT,Anh Dao NL,Thanh Huong DT,Quetin-Leclercq J,Scippo ML,Phuong NT,Kestemont P

更新日期：2020-05-05 00:00:00

abstract：:In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca(++), the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc pro...

journal_title：Frontiers in immunology

authors： Rudolf R,Busch R,Patra AK,Muhammad K,Avots A,Andrau JC,Klein-Hessling S,Serfling E

更新日期：2014-02-03 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at least four different virus families: Arenaviridae, Bunyaviridae,...

journal_title：Frontiers in immunology

authors： Schönrich G,Raftery MJ

更新日期：2017-09-26 00:00:00

abstract：:Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

journal_title：Frontiers in immunology

authors： Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

更新日期：2019-05-09 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：:Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As a trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) are associated with the genesis of antibody-mediated rej...

journal_title：Frontiers in immunology

authors： Danger R,Chesneau M,Delbos F,Le Bot S,Kerleau C,Chenouard A,Ville S,Degauque N,Conchon S,Cesbron A,Giral M,Brouard S

更新日期：2019-09-10 00:00:00

abstract：:Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T cell immunity. To understand the impact of prematurity on the hu...

journal_title：Frontiers in immunology

authors： Carey AJ,Hope JL,Mueller YM,Fike AJ,Kumova OK,van Zessen DBH,Steegers EAP,van der Burg M,Katsikis PD

更新日期：2017-12-19 00:00:00

abstract：:Enamel matrix derivatives (EMDs)-based periodontal tissue regenerative therapy is known to promote healing with minimal inflammatory response after periodontal surgery, i. e., it promotes wound healing with reduced pain and swelling. It has also been reported that macrophages stimulated with amelogenin, a major compon...

journal_title：Frontiers in immunology

authors： Yotsumoto K,Sanui T,Tanaka U,Yamato H,Alshargabi R,Shinjo T,Nakao Y,Watanabe Y,Hayashi C,Taketomi T,Fukuda T,Nishimura F

更新日期：2020-04-21 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:Dendritic cells (DC), master antigen-presenting cells that orchestrate interactions between the adaptive and innate immune arms, are increasingly utilized in cancer immunotherapy. Despite remarkable progress in our understanding of DC immunobiology, as well as several encouraging clinical applications - such as DC-bas...

journal_title：Frontiers in immunology

authors： Datta J,Berk E,Cintolo JA,Xu S,Roses RE,Czerniecki BJ

更新日期：2015-06-02 00:00:00

abstract：:CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from healthy donors, mul...

journal_title：Frontiers in immunology

authors： Kunkl M,Mastrogiovanni M,Porciello N,Caristi S,Monteleone E,Arcieri S,Tuosto L

更新日期：2019-04-24 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00

abstract：:The diversity of the immune repertoire is important for the adaptive immune system's ability to detect pathogens. Much of this diversity is generated in two steps, first through the recombination of germline gene segments and second through hypermutation during an immune response. While both steps are to some extent b...

journal_title：Frontiers in immunology

authors： Schwartz GW,Hershberg U

更新日期：2013-11-08 00:00:00

abstract：:Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its inf...

journal_title：Frontiers in immunology

authors： Morath C,Döhler B,Kälble F,Pego da Silva L,Echterdiek F,Schwenger V,Živčić-Ćosić S,Katalinić N,Kuypers D,Benöhr P,Haubitz M,Ziemann M,Nitschke M,Emmerich F,Pisarski P,Karakizlis H,Weimer R,Ruhenstroth A,Scherer S,Tr

更新日期：2020-08-26 00:00:00

abstract：:Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-03-03 00:00:00

abstract：:DExD/H-box helicase 36 (DHX36) is known to be an ATP-dependent RNA helicase that unwinds the guanine-quadruplexes DNA or RNA, but emerging data suggest that it also functions as pattern recognition receptor in innate immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been ...

journal_title：Frontiers in immunology

authors： Jing H,Zhou Y,Fang L,Ding Z,Wang D,Ke W,Chen H,Xiao S

更新日期：2017-10-23 00:00:00