Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages.


:Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be beneficial. Here, we show that resveratrol is able to boost xenophagy, a selective form of autophagy that target invasive bacteria. We demonstrated that resveratrol promotes in vitro autophagy-dependent clearance of intracellular bacteria in intestinal epithelial cells and macrophages. These results were validated in vivo using infection in a transgenic GFP-LC3 zebrafish model. We also compared the ability of resveratrol derivatives, designed to improve the bioavailability of the parent molecule, to stimulate autophagy and to induce intracellular bacteria clearance. Together, our data demonstrate the ability of resveratrol to stimulate xenophagy, and thereby enhance the clearance of two invasive bacteria involved life-threatening diseases, Salmonella Typhimurium and Crohn's disease-associated Adherent-Invasive Escherichia coli. These findings encourage the further development of pro-autophagic nutrients to strengthen intestinal homeostasis in basal and infectious states.


Front Immunol


Frontiers in immunology


Al Azzaz J,Rieu A,Aires V,Delmas D,Chluba J,Winckler P,Bringer MA,Lamarche J,Vervandier-Fasseur D,Dalle F,Lapaquette P,Guzzo J




Has Abstract


2019-01-14 00:00:00








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    abstract::Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

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    pub_type: 杂志文章


    authors: Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

    更新日期:2020-06-02 00:00:00

  • IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole.

    abstract::Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

    更新日期:2019-06-04 00:00:00

  • Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species.

    abstract::Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system...

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    pub_type: 杂志文章,评审


    authors: Huang Z,Aweya JJ,Zhu C,Tran NT,Hong Y,Li S,Yao D,Zhang Y

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  • The relationship between CD27 negative and positive B cell populations in human peripheral blood.

    abstract::CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in human...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wu YC,Kipling D,Dunn-Walters DK

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  • Interplay of Regulatory T Cell and Th17 Cells during Infectious Diseases in Humans and Animals.

    abstract::It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sehrawat S,Rouse BT

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  • Structurally Mapping Antibody Repertoires.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Krawczyk K,Kelm S,Kovaltsuk A,Galson JD,Kelly D,Trück J,Regep C,Leem J,Wong WK,Nowak J,Snowden J,Wright M,Starkie L,Scott-Tucker A,Shi J,Deane CM

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  • Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Schönrich G,Raftery MJ

    更新日期:2017-09-26 00:00:00

  • Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,meta分析


    authors: Chen HJ,Li Yim AYF,Griffith GR,de Jonge WJ,Mannens MMAM,Ferrero E,Henneman P,de Winther MPJ

    更新日期:2019-12-11 00:00:00

  • Molecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression.

    abstract:Background:Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu Y,Xie P,Jiang D,Liu J,Zhang J,Bian T,Shi J

    更新日期:2020-12-07 00:00:00

  • CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kunkl M,Mastrogiovanni M,Porciello N,Caristi S,Monteleone E,Arcieri S,Tuosto L

    更新日期:2019-04-24 00:00:00

  • Antigenic Variability.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mosa AI

    更新日期:2020-09-11 00:00:00

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    pub_type: 杂志文章


    authors: Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kim Y,Born C,Bléry M,Steinle A

    更新日期:2020-06-04 00:00:00

  • Ruggero Ceppellini: A Perspective on His Contributions to Genetics and Immunology.

    abstract::Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

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    pub_type: 传,历史文章,杂志文章


    authors: Bodmer W

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Liu R,Nikolajczyk BS

    更新日期:2019-07-17 00:00:00

  • IL-34 Actions on FOXP3+ Tregs and CD14+ Monocytes Control Human Graft Rejection.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

    更新日期:2020-08-11 00:00:00

  • Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Renner K,Singer K,Koehl GE,Geissler EK,Peter K,Siska PJ,Kreutz M

    更新日期:2017-03-08 00:00:00

  • Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies.

    abstract::Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Morrison MC,Kleemann R

    更新日期:2015-06-15 00:00:00

  • Regulatory B Cells and Its Role in Central Nervous System Inflammatory Demyelinating Diseases.

    abstract::Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

    更新日期:2020-08-20 00:00:00

  • Neddylation Facilitates the Antiviral Response in Zebrafish.

    abstract::Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

    更新日期:2019-06-25 00:00:00

  • HIST1H1C Regulates Interferon-β and Inhibits Influenza Virus Replication by Interacting with IRF3.

    abstract::Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

    更新日期:2017-03-24 00:00:00

  • Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control.

    abstract::Natural killer (NK) cells are known for their well characterized ability to control viral infections and eliminate tumor cells. Through their repertoire of activating and inhibitory receptors, NK cells are able to survey different potential target cells for various surface markers, such as MHC-I - which signals to the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Tu MM,Mahmoud AB,Makrigiannis AP

    更新日期:2016-05-02 00:00:00

  • Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation.

    abstract::It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

    更新日期:2019-05-31 00:00:00

  • Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages.

    abstract::Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Damby DE,Horwell CJ,Baxter PJ,Kueppers U,Schnurr M,Dingwell DB,Duewell P

    更新日期:2018-01-22 00:00:00

  • Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy.

    abstract::Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respir...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Vázquez A,Fernández-Sevilla LM,Jiménez E,Pérez-Cabrera D,Yañez R,Subiza JL,Varas A,Valencia J,Vicente A

    更新日期:2020-11-19 00:00:00

  • Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: de Melo CVB,Hermida MD,Mesquita BR,Fontes JLM,Koning JJ,Solcà MDS,Benevides BB,Mota GBS,Freitas LAR,Mebius RE,Dos-Santos WLC

    更新日期:2020-04-15 00:00:00

  • Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong.

    abstract::The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

    更新日期:2020-07-16 00:00:00

  • Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling.

    abstract::High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

    更新日期:2013-12-23 00:00:00

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    abstract:Introduction:High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Marín-Palma D,Castro GA,Cardona-Arias JA,Urcuqui-Inchima S,Hernandez JC

    更新日期:2018-06-14 00:00:00

  • Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zenclussen AC,Hämmerling GJ

    更新日期:2015-06-17 00:00:00