Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases.

abstract：:Among all T and NK cell subsets, regulatory T (Treg) cells typically respond to the lowest concentrations of IL-2 due to elevated surface expression of the IL-2R alpha chain (IL2RA; CD25) and the high affinity IL-2 receptor (IL-2R) complex. This enhanced sensitivity forms the basis for low-dose (LD) IL-2 therapy for t...

journal_title：Frontiers in immunology

authors： Ghelani A,Bates D,Conner K,Wu MZ,Lu J,Hu YL,Li CM,Chaudhry A,Sohn SJ

更新日期：2020-06-05 00:00:00

abstract：:Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pat...

journal_title：Frontiers in immunology

authors： Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HR

更新日期：2018-11-20 00:00:00

abstract：:CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in human...

journal_title：Frontiers in immunology

authors： Wu YC,Kipling D,Dunn-Walters DK

更新日期：2011-12-26 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:Mucin 1 (MUC1) is a transmembrane mucin glycoprotein that is over-expressed and aberrantly glycosylated in >80% of human pancreatic ductal adenocarcinoma (PDA) and is associated with poor prognosis. To understand the role of MUC1 in PDA, we have recently developed two mouse models of spontaneous PDA, one that expresse...

journal_title：Frontiers in immunology

authors： Kidiyoor A,Schettini J,Besmer DM,Rego SL,Nath S,Curry JM,Roy LD,Dréau D,Mukherjee P

更新日期：2014-02-24 00:00:00

abstract：:Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, ...

journal_title：Frontiers in immunology

authors： Morrison MC,Kleemann R

更新日期：2015-06-15 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad capsid is currently being investigated as an alternative approach of vaccination. The present study seeks to better understand virus- and host-related factors controlling the effica...

journal_title：Frontiers in immunology

authors： Anchim A,Raddi N,Zig L,Perrieau P,Le Goffic R,Ryffel B,Benihoud K

更新日期：2018-02-05 00:00:00

abstract：:Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige...

journal_title：Frontiers in immunology

authors： Chaurasia B,Talbot CL,Summers SA

更新日期：2020-09-23 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed after antigen clearance and a long-term resting phase accompanied ...

journal_title：Frontiers in immunology

authors： Onodera A,Kokubo K,Nakayama T

更新日期：2018-12-12 00:00:00

abstract：:The potential of tolerogenic dendritic cells (tolDCs) to shape immune responses and restore tolerance has turn them into a promising therapeutic tool for cellular therapies directed toward immune regulation in autoimmunity. Although the cellular mechanisms by which these cells can exert their regulatory function are w...

journal_title：Frontiers in immunology

authors： García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

更新日期：2019-05-28 00:00:00

abstract：:Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination (CSR) defects associated with hyper-...

journal_title：Frontiers in immunology

authors： Jhamnani RD,Nunes-Santos CJ,Bergerson J,Rosenzweig SD

更新日期：2018-09-26 00:00:00

abstract：:Many current vaccines are less immunogenic and less effective in elderly compared to younger adults due to age-related changes of the immune system. Most vaccines utilized in the elderly contain antigens, which the target population has had previous contact with due to previous vaccination or infection. Therefore, mos...

journal_title：Frontiers in immunology

authors： Weinberger B,Haks MC,de Paus RA,Ottenhoff THM,Bauer T,Grubeck-Loebenstein B

更新日期：2018-05-15 00:00:00

abstract：:Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

journal_title：Frontiers in immunology

authors： Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

更新日期：2020-07-16 00:00:00

abstract：:Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

journal_title：Frontiers in immunology

authors： Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

更新日期：2020-10-23 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains elusive. We perform...

journal_title：Frontiers in immunology

authors： Lim SA,Kim J,Jeon S,Shin MH,Kwon J,Kim TJ,Im K,Han Y,Kwon W,Kim SW,Yee C,Kim SJ,Jang JY,Lee KM

更新日期：2019-04-09 00:00:00

abstract：:Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulati...

journal_title：Frontiers in immunology

authors： Zhang Y,Jin Y,Guan Z,Li H,Su Z,Xie C,Chen X,Liu X,Pan Y,Ye P,Zhang L,Kong Y,Luo W

更新日期：2020-03-10 00:00:00

abstract：:Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid...

journal_title：Frontiers in immunology

authors： Lee SM,Yip TF,Yan S,Jin DY,Wei HL,Guo RT,Peiris JSM

更新日期：2018-03-16 00:00:00

abstract：:CD4+ T cells play a central role in orchestrating protective immunity and autoimmunity. The activation and differentiation of myelin-reactive CD4+ T cells into effector (Th1 and Th17) and regulatory (Tregs) subsets at the peripheral tissues, and their subsequent transmigration across the blood-brain barrier (BBB) into...

journal_title：Frontiers in immunology

authors： Sonar SA,Lal G

更新日期：2017-11-29 00:00:00

abstract：:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...

journal_title：Frontiers in immunology

authors： Costa MC,Paixão CS,Viana DL,Rocha BO,Saldanha M,da Mota LMH,Machado PRL,Pagliari C,de Oliveira MF,Arruda S,Carvalho EM,Carvalho LP

更新日期：2020-03-25 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of this polymorphism, whi...

journal_title：Frontiers in immunology

authors： Bray C,Wright D,Haupt S,Thomas S,Stauss H,Zamoyska R

更新日期：2018-11-12 00:00:00

abstract：:The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has generated a significant repercussion on the administration of adoptive cell therapies, including chimeric antigen receptor (CAR) T-cells. The closing of borders, the reduction of people transit and the confinement of the...

journal_title：Frontiers in immunology

authors： Ortiz de Landazuri I,Egri N,Muñoz-Sánchez G,Ortiz-Maldonado V,Bolaño V,Guijarro C,Pascal M,Juan M

更新日期：2020-10-15 00:00:00

abstract：:Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs. 31%, effectivity in combination regimen, e.g., with lenalidomide or bortezomib plus dexametha...

journal_title：Frontiers in immunology

authors： Seckinger A,Hillengass J,Emde M,Beck S,Kimmich C,Dittrich T,Hundemer M,Jauch A,Hegenbart U,Raab MS,Ho AD,Schönland S,Hose D

更新日期：2018-07-20 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

journal_title：Frontiers in immunology

authors： Liu R,Nikolajczyk BS

更新日期：2019-07-17 00:00:00

abstract：:Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion ...

journal_title：Frontiers in immunology

authors： Darweesh M,Kamel W,Gavrilin MA,Akusjärvi G,Svensson C

更新日期：2019-11-28 00:00:00

abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic disorder, belonging to the small vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, defined as an eosinophil-rich and necrotizing granulomatous inflammation often involving the respiratory tract, and necrotizing vasculitis p...

journal_title：Frontiers in immunology

authors： Gioffredi A,Maritati F,Oliva E,Buzio C

更新日期：2014-11-03 00:00:00