Abstract:
:Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Díaz-Muñoz MD,Turner Mdoi
10.3389/fimmu.2018.01094subject
Has Abstractpub_date
2018-05-23 00:00:00pages
1094issn
1664-3224journal_volume
9pub_type
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