Evolutionary Regression and Species-Specific Codon Usage of TLR15.

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

journal_title：Frontiers in immunology

authors： Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

更新日期：2018-07-26 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor kidney for rejection, and contributes to the long-term risk of graft loss. In the last decade, epidemiological studies have linked ...

journal_title：Frontiers in immunology

authors： Tammaro A,Kers J,Scantlebery AML,Florquin S

更新日期：2020-07-07 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. Within this network, individual DC subsets display highly specific rol...

journal_title：Frontiers in immunology

authors： Chopin M,Allan RS,Belz GT

更新日期：2012-02-27 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:Efficient tuberculosis (TB) control depends on early TB prediction and prevention. Solution to these tasks requires knowledge of TB protection correlates (TB CoPs), i.e., laboratory markers that are mechanistically involved in the protection and which allow to determine how well an individual is protected against TB o...

journal_title：Frontiers in immunology

authors： Lyadova I,Nikitina I

更新日期：2019-05-08 00:00:00

abstract：:Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...

journal_title：Frontiers in immunology

authors： Weber TS

更新日期：2018-06-12 00:00:00

abstract：:The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect ...

journal_title：Frontiers in immunology

authors： Elias-Oliveira J,Leite JA,Pereira ÍS,Guimarães JB,Manso GMDC,Silva JS,Tostes RC,Carlos D

更新日期：2020-08-11 00:00:00

abstract：:Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immatu...

journal_title：Frontiers in immunology

authors： Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

更新日期：2017-11-13 00:00:00

abstract：:S100A12 is a calcium-binding protein of the S100 subfamily of myeloid-related proteins that acts as an alarmin to induce a pro-inflammatory innate immune response. It has been linked to several chronic inflammatory diseases, however its role in the common oral immunopathology periodontitis is largely unknown. Previous...

journal_title：Frontiers in immunology

authors： Lira-Junior R,Holmström SB,Clark R,Zwicker S,Majster M,Johannsen G,Axtelius B,Åkerman S,Svensson M,Klinge B,Boström EA

更新日期：2020-01-31 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：:In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clin...

journal_title：Frontiers in immunology

authors： Owen A,Newsome PN

更新日期：2020-06-19 00:00:00

abstract：:Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

journal_title：Frontiers in immunology

authors： Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

更新日期：2016-03-01 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：:The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate i...

journal_title：Frontiers in immunology

authors： Sherman H,Gitschier HJ,Rossi AE

更新日期：2018-04-23 00:00:00

abstract：:DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear. Hence, th...

journal_title：Frontiers in immunology

authors： Zhang Y,Han Y,Zhao Y,Lv Y,Hu Y,Tan Y,Bi X,Yu B,Kou J

更新日期：2017-08-14 00:00:00

abstract：:The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight ...

journal_title：Frontiers in immunology

authors： Pednekar L,Pathan AA,Paudyal B,Tsolaki AG,Kaur A,Abozaid SM,Kouser L,Khan HA,Peerschke EI,Shamji MH,Stenbeck G,Ghebrehiwet B,Kishore U

更新日期：2016-12-13 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reacti...

journal_title：Frontiers in immunology

authors： Solloch UV,Schefzyk D,Schäfer G,Massalski C,Kohler M,Pruschke J,Heidl A,Schetelig J,Schmidt AH,Lange V,Sauter J

更新日期：2020-03-12 00:00:00

abstract：:Intact (146S) foot-and-mouth disease virus (FMDVs) can dissociate into specific (12S) viral capsid degradation products. FMD vaccines normally consist of inactivated virions. Vaccine quality is dependent on 146S virus particles rather than 12S particles. We earlier isolated two llama single-domain antibody fragments (...

journal_title：Frontiers in immunology

authors： Harmsen MM,Seago J,Perez E,Charleston B,Eblé PL,Dekker A

更新日期：2017-08-17 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

journal_title：Frontiers in immunology

authors： Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

更新日期：2020-10-06 00:00:00

abstract：:B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R expression in RA. Flo...

journal_title：Frontiers in immunology

authors： Dam EM,Maier AC,Hocking AM,Carlin J,Ng B,Buckner JH

更新日期：2018-09-05 00:00:00

abstract：:Immunotherapy with anti-CD20-specific antibodies (rituximab), has become the standard of care for B cell lymphoproliferative disorders and many autoimmune diseases. In rheumatological patients the effect of rituximab on bone mass yielded conflicting results, while in lymphoma patients it has not yet been described. He...

journal_title：Frontiers in immunology

authors： Kolomansky A,Kaye I,Ben-Califa N,Gorodov A,Awida Z,Sadovnic O,Ibrahim M,Liron T,Hiram-Bab S,Oster HS,Sarid N,Perry C,Gabet Y,Mittelman M,Neumann D

更新日期：2020-10-19 00:00:00

abstract：:Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

journal_title：Frontiers in immunology

authors： Nelson SA,Sant AJ

更新日期：2019-05-07 00:00:00

abstract：:Epithelial damage and loss of intestinal barrier function are hallmark pathologies of the mucosal inflammation associated with conditions such as inflammatory bowel disease. In order to resolve inflammation and restore intestinal integrity the mucosa must rapidly and effectively repair the epithelial barrier. Epitheli...

journal_title：Frontiers in immunology

authors： Goggins BJ,Chaney C,Radford-Smith GL,Horvat JC,Keely S

更新日期：2013-09-11 00:00:00

abstract：:Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor cells and the number and activity of tumor-infiltrating T cells represent a good marker for tumor prognosis. Based on these findings, immunotherapy, e.g., checkpoint blockade, has received considerable attention during the last ...

journal_title：Frontiers in immunology

authors： Renner K,Singer K,Koehl GE,Geissler EK,Peter K,Siska PJ,Kreutz M

更新日期：2017-03-08 00:00:00

abstract：:CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

journal_title：Frontiers in immunology

authors： Schmitt EG,Williams CB

更新日期：2013-06-19 00:00:00