Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System.

abstract：:The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is know...

journal_title：Frontiers in immunology

authors： Maeda DLNF,Batista MT,Pereira LR,de Jesus Cintra M,Amorim JH,Mathias-Santos C,Pereira SA,Boscardin SB,Silva SDR,Faquim-Mauro EL,Silveira VB,Oliveira DBL,Johnston SA,Ferreira LCS,Rodrigues JF

更新日期：2017-09-25 00:00:00

abstract：:Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-indu...

journal_title：Frontiers in immunology

authors： Alberca RW,Pereira NZ,Oliveira LMDS,Gozzi-Silva SC,Sato MN

更新日期：2020-07-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

journal_title：Frontiers in immunology

authors： Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

更新日期：2019-07-24 00:00:00

abstract：:T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a pathogen inform and reinforce memory, leading to a mature state. The complexity and temporal stability of this system in man is only beginning to be ade...

journal_title：Frontiers in immunology

authors： Naumova EN,Yassai MB,Demos W,Reed E,Unruh M,Haribhai D,Williams CB,Naumov YN,Gorski J

更新日期：2019-08-06 00:00:00

abstract：:In the last two decades, extracellular vesicles (EVs) have aroused wide interest among researchers in basic and clinical research. EVs, small membrane vesicles are released by almost all kinds of cells into the extracellular environment. According to many recent studies, EVs participate in immunomodulation and play an...

journal_title：Frontiers in immunology

authors： Zhang B,Zhao M,Lu Q

更新日期：2021-01-14 00:00:00

abstract：:We characterized five different vaccine candidates and a commercial vaccine in terms of safety, immunogenicity and using a systems vaccinology approach, with the aim to select novel vaccine candidates against Mycoplasma hyopneumoniae. Seven groups of six M. hyopneumoniae-free piglets were primo- and booster vaccinated...

journal_title：Frontiers in immunology

authors： Matthijs AMF,Auray G,Jakob V,García-Nicolás O,Braun RO,Keller I,Bruggman R,Devriendt B,Boyen F,Guzman CA,Michiels A,Haesebrouck F,Collin N,Barnier-Quer C,Maes D,Summerfield A

更新日期：2019-05-24 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early infection and host re...

journal_title：Frontiers in immunology

authors： Rosenbaum P,Tchitchek N,Joly C,Stimmer L,Hocini H,Dereuddre-Bosquet N,Beignon AS,Chapon C,Levy Y,Le Grand R,Martinon F

更新日期：2018-04-25 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：Background:The role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via activation of the complement system or as direct opsonins. As recent ...

journal_title：Frontiers in immunology

authors： Vogt S,Trendelenburg M,Tamm M,Stolz D,Hostettler KE,Osthoff M

更新日期：2020-09-23 00:00:00

abstract：:Therapeutic approaches that engage immune cells to treat cancer are becoming increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid tumor types. Most of the current immunotherapies focus on manipulating T cells, however, the tumor microenvironment (TME) is abundantly infiltrate...

journal_title：Frontiers in immunology

authors： Clappaert EJ,Murgaski A,Van Damme H,Kiss M,Laoui D

更新日期：2018-10-08 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:Human pregnancy is accompanied by a mild systemic inflammatory response, which includes the activation of monocytes circulating in maternal blood. This response is exaggerated in preeclampsia, a placental-dependent disorder specific to human pregnancies. We and others showed that placental syncytiotrophoblast membrane...

journal_title：Frontiers in immunology

authors： Joerger-Messerli MS,Hoesli IM,Rusterholz C,Lapaire O

更新日期：2014-04-15 00:00:00

abstract：:A sudden outbreak of COVID-19 caused by a novel coronavirus, SARS-CoV-2, in Wuhan, China in December 2019 quickly grew into a global pandemic, putting at risk not only the global healthcare system, but also the world economy. As the disease continues to spread rapidly, the development of prophylactic and therapeutic a...

journal_title：Frontiers in immunology

authors： Liang Y,Wang ML,Chien CS,Yarmishyn AA,Yang YP,Lai WY,Luo YH,Lin YT,Chen YJ,Chang PC,Chiou SH

更新日期：2020-05-12 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a common and devastating autoimmune disease, characterized by a dysregulated adaptive immune response against intracellular antigens, which involves both autoreactive T and B cells. In SLE, mainly intracellular autoantigens generate autoantibodies and these assemble into immune co...

journal_title：Frontiers in immunology

authors： Ugarte-Berzal E,Boon L,Martens E,Rybakin V,Blockmans D,Vandooren J,Proost P,Opdenakker G

更新日期：2019-03-22 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：:Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. P...

journal_title：Frontiers in immunology

authors： Reed AM,Crowson CS,Dvergsten JA

更新日期：2019-04-02 00:00:00

abstract：:CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyte glycoprotein pept...

journal_title：Frontiers in immunology

authors： Dagkonaki A,Avloniti M,Evangelidou M,Papazian I,Kanistras I,Tseveleki V,Lampros F,Tselios T,Jensen LT,Möbius W,Ruhwedel T,Androutsou ME,Matsoukas J,Anagnostouli M,Lassmann H,Probert L

更新日期：2020-11-19 00:00:00

abstract：:Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressiv...

journal_title：Frontiers in immunology

authors： Stegner D,Klaus V,Nieswandt B

更新日期：2019-11-01 00:00:00

abstract：:Background: Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic lesions are a consequence of renal inflammation or independently contribute to renal damage is unclear. Our aim was to investigate the relationship bet...

journal_title：Frontiers in immunology

authors： Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M

更新日期：2018-08-28 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00

abstract：:Solid organ transplant recipients (SOTRs) are at increased risk for many infections, whether viral, bacterial, or fungal, due to immunosuppressive therapy to prevent organ rejection. The same immune defects that render transplanted patients susceptible to infection dampen their immune response to vaccination. Therefor...

journal_title：Frontiers in immunology

authors： Scanlon N,Saklawi Y,Rouphael N

更新日期：2020-11-25 00:00:00

abstract：:Over the past two decades, heat shock proteins (HSPs) have been implicated in inflammatory responses and autoimmunity. HSPs were originally believed to maintain protein quality control in the cytosol. However, they also exist extracellularly and appear to act as inflammatory factors. Recently, a growing body of eviden...

journal_title：Frontiers in immunology

authors： Morito D,Nagata K

更新日期：2012-03-15 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：:Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental m...

journal_title：Frontiers in immunology

authors： Maria ATJ,Rozier P,Fonteneau G,Sutra T,Maumus M,Toupet K,Cristol JP,Jorgensen C,Guilpain P,Noël D

更新日期：2018-12-21 00:00:00

abstract：:Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells. ILCs are present in lymphoid and non-lympho...

journal_title：Frontiers in immunology

authors： Panda SK,Colonna M

更新日期：2019-05-07 00:00:00

abstract：:The gastrointestinal tract hosts the largest collection of commensal microbes in the body. Infections at this site can cause significant perturbations in the microbiota, known as dysbiosis, that facilitate the expansion of pathobionts, and can elicit inappropriate immune responses that impair the intestinal barrier fu...

journal_title：Frontiers in immunology

authors： Cervantes-Barragan L,Cortez VS,Wang Q,McDonald KG,Chai JN,Di Luccia B,Gilfillan S,Hsieh CS,Newberry RD,Sibley LD,Colonna M

更新日期：2019-07-02 00:00:00