Bovine Neonatal Pancytopenia-Associated Alloantibodies Recognize Individual Bovine Leukocyte Antigen 1 Alleles.

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a protective CD8 T-cell ep...

journal_title：Frontiers in immunology

authors： Minigo G,Flanagan KL,Slattery RM,Plebanski M

更新日期：2017-02-14 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hBtk) display spontaneous ...

journal_title：Frontiers in immunology

authors： Rip J,de Bruijn MJW,Appelman MK,Pal Singh S,Hendriks RW,Corneth OBJ

更新日期：2019-01-30 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs. Interestingly, FRCs also display antigen presentation capacities and support lymphocyte survival. CXCR5+CD4+ follicular T cells are impor...

journal_title：Frontiers in immunology

authors： Misiak J,Jean R,Rodriguez S,Deleurme L,Lamy T,Tarte K,Amé-Thomas P

更新日期：2020-10-02 00:00:00

abstract：:Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initial phase I trials demonstrated that the administration of a number of...

journal_title：Frontiers in immunology

authors： Phillips BE,Garciafigueroa Y,Engman C,Trucco M,Giannoukakis N

更新日期：2019-02-06 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunomodulatory function. To study the mechanism by which MDSC affect antimicrobial immunity, we infected mice with two M. avium strains of differential virulence, highly virulent Mycobacterium avium subsp. avium strain 25291 (MAA) and low virule...

journal_title：Frontiers in immunology

authors： Abdissa K,Nerlich A,Beineke A,Ruangkiattikul N,Pawar V,Heise U,Janze N,Falk C,Bruder D,Schleicher U,Bogdan C,Weiss S,Goethe R

更新日期：2018-10-16 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pat...

journal_title：Frontiers in immunology

authors： Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HR

更新日期：2018-11-20 00:00:00

abstract：:Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5-7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correlated to specific clinico-pathological features, such as primary imatini...

journal_title：Frontiers in immunology

authors： Indio V,Ravegnini G,Astolfi A,Urbini M,Saponara M,De Leo A,Gruppioni E,Tarantino G,Angelini S,Pession A,Pantaleo MA,Nannini M

更新日期：2020-06-02 00:00:00

abstract：:It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs ...

journal_title：Frontiers in immunology

authors： Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

更新日期：2019-05-31 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the cardiovascular system. Atherosclerosis is the most common cardiovascular complication of SLE and a significant risk factor for morbidity and mortality. Vascular damage/protection mechanism in SLE patients is out of balance, caused by...

journal_title：Frontiers in immunology

authors： Ding X,Xiang W,He X

更新日期：2020-11-11 00:00:00

abstract：:In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in effector lymphocytes. Whereas NFATc1 is not expressed in plasma cells, ...

journal_title：Frontiers in immunology

authors： Muhammad K,Rudolf R,Pham DAT,Klein-Hessling S,Takata K,Matsushita N,Ellenrieder V,Kondo E,Serfling E

更新日期：2018-01-24 00:00:00

abstract：:Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological ...

journal_title：Frontiers in immunology

authors： Luo Y,Meyer N,Jiao Q,Scheffel J,Zimmermann C,Metz M,Zenclussen A,Maurer M,Siebenhaar F

更新日期：2019-10-15 00:00:00

abstract：:Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabol...

journal_title：Frontiers in immunology

authors： Miccadei S,Masella R,Mileo AM,Gessani S

更新日期：2016-11-15 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strateg...

journal_title：Frontiers in immunology

authors： Ochando J,Conde P,Utrero-Rico A,Paz-Artal E

更新日期：2019-03-06 00:00:00

abstract：:Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and ...

journal_title：Frontiers in immunology

authors： Ariel A,Serhan CN

更新日期：2012-01-31 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.01529.]. ...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-11-18 00:00:00

abstract：:Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes. The concept of harnessing DC immunogenicity to induce protective responses in cancer patients was ...

journal_title：Frontiers in immunology

authors： Cancel JC,Crozat K,Dalod M,Mattiuz R

更新日期：2019-02-12 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate...

journal_title：Frontiers in immunology

authors： Iragavarapu-Charyulu V,Wojcikiewicz E,Urdaneta A

更新日期：2020-03-05 00:00:00

abstract：:Celiac Disease (CD) is a multifactorial, autoimmune enteropathy activated by cereal proteins in genetically predisposed individuals carrying HLA DQ2/8 genes. A heterogenous gene combination of the cereal prolamins is documented in different wheat genotypes, which is suggestive of their variable immunogenic potential. ...

journal_title：Frontiers in immunology

authors： Grover J,Chhuneja P,Midha V,Ghia JE,Deka D,Mukhopadhyay CS,Sood N,Mahajan R,Singh A,Verma R,Bansal E,Sood A

更新日期：2019-02-04 00:00:00

abstract：:Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions,...

journal_title：Frontiers in immunology

authors： Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:Serotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a World Health Organization (WHO)-standardized enzyme-linked immunosorbent assay (ELISA) are the gold standard for diagnosis of specific polysaccharide antibody deficiency (SAD). The American Academy o...

journal_title：Frontiers in immunology

authors： Schaballie H,Bosch B,Schrijvers R,Proesmans M,De Boeck K,Boon MN,Vermeulen F,Lorent N,Dillaerts D,Frans G,Moens L,Derdelinckx I,Peetermans W,Kantsø B,Jørgensen CS,Emonds MP,Bossuyt X,Meyts I

更新日期：2017-05-12 00:00:00

abstract：:Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. Methods: ...

journal_title：Frontiers in immunology

authors： Diao B,Wang C,Tan Y,Chen X,Liu Y,Ning L,Chen L,Li M,Liu Y,Wang G,Yuan Z,Feng Z,Zhang Y,Wu Y,Chen Y

更新日期：2020-05-01 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Macrophages form an important component of the innate immune system and serve as first responders against invading pathogens. While pathways critical for initiation of inflammatory responses between macrophages and other LysM+ myeloid cells are largely similar, it remains unknown whether a specific pathway has differe...

journal_title：Frontiers in immunology

authors： Xiong X,Mathewson ND,Li H,Tan M,Fujiwara H,Li H,Reddy P,Sun Y

更新日期：2018-12-06 00:00:00