Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation.

abstract：:Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation analysis in CVID-disco...

journal_title：Frontiers in immunology

authors： Del Pino-Molina L,Rodríguez-Ubreva J,Torres Canizales J,Coronel-Díaz M,Kulis M,Martín-Subero JI,van der Burg M,Ballestar E,López-Granados E

更新日期：2019-04-24 00:00:00

abstract：:Staphylococcus aureus is a notorious bacterial pathogen that often causes soft tissue and bloodstream infections and invariably garners resistance mechanisms against new antibiotics. Modulation of the host immune response by metabolites is a powerful tool against bacterial infections, but has not yet been used against...

journal_title：Frontiers in immunology

authors： Pang R,Zhou H,Huang Y,Su Y,Chen X

更新日期：2020-07-28 00:00:00

abstract：:How B cells contribute to protective immunity against parasitic nematodes remains unclear, with their importance as accessory cells underexplored. In this study, anti-CD20 monoclonal antibody (α-CD20 mAb)-mediated depletion of B cells from C57BL/6 mice revealed an important role for B cells in supporting Th2 immune re...

journal_title：Frontiers in immunology

authors： Sahputra R,Ruckerl D,Couper KN,Muller W,Else KJ

更新日期：2019-12-10 00:00:00

abstract：:Dengue is considered the most important emerging, human arboviruses, with worldwide distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or specific anti-viral drugs. The development of a dengue vaccine faces unique challenges. The four serotypes co-circulate in endemic areas, an...

journal_title：Frontiers in immunology

authors： Sariol CA,White LJ

更新日期：2014-09-24 00:00:00

abstract：:Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence neoplastic cell functional behavior, remodeling TME and generating a tumor cell niche that supports tissue neovascularization, tumor invasion an...

journal_title：Frontiers in immunology

authors： Poggi A,Varesano S,Zocchi MR

更新日期：2018-02-19 00:00:00

abstract：:The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases. Some of them are primarily complement-mediated rare diseases, such as paroxysmal nocturnal hemoglobinuria, C3 glomerulonephritis, and a...

journal_title：Frontiers in immunology

authors： Dobó J,Kocsis A,Gál P

更新日期：2018-08-08 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Candida is a dominant fungal pathogen in immunocompromised hosts, leading to opportunistic infections. Complement with its multifaceted functions is involved in the immune defense against this yeast, and recently several novel aspects have emerged in this old battle. It is clear that Candida can adopt both roles as a ...

journal_title：Frontiers in immunology

authors： Harpf V,Rambach G,Würzner R,Lass-Flörl C,Speth C

更新日期：2020-07-14 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the mos...

journal_title：Frontiers in immunology

authors： Hudson KE,de Wolski K,Kapp LM,Richards AL,Schniederjan MJ,Zimring JC

更新日期：2017-10-30 00:00:00

abstract：:Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is a potential HIV-1 ...

journal_title：Frontiers in immunology

authors： Pandit H,Kale K,Yamamoto H,Thakur G,Rokade S,Chakraborty P,Vasudevan M,Kishore U,Madan T,Fichorova RN

更新日期：2019-03-28 00:00:00

abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...

journal_title：Frontiers in immunology

authors： Pang YP,Casal Moura M,Thompson GE,Nelson DR,Hummel AM,Jenne DE,Emerling D,Volkmuth W,Robinson WH,Specks U

更新日期：2019-10-25 00:00:00

abstract：:Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic...

journal_title：Frontiers in immunology

authors： Li B,Hu Y,Zhao Y,Cheng M,Qin H,Cheng T,Wang Q,Peng X,Zhang X

更新日期：2017-01-31 00:00:00

abstract：:Have potential clues to an effective gonorrhea vaccine been lurking in international disease surveillance data for decades? While no clinically effective vaccines against gonorrhea have been developed we present direct and indirect evidence that a vaccine is not only possible, but may already exist. Experience from Cu...

journal_title：Frontiers in immunology

authors： Petousis-Harris H,Radcliff FJ

更新日期：2019-04-09 00:00:00

abstract：:The large family of chemoattractant cytokines (chemokines) embraces multiple, in part unrelated functions that go well beyond chemotaxis. Undoubtedly, the control of immune cell migration (chemotaxis) is the single, unifying response mediated by all chemokines, which involves the sequential engagement of chemokine rec...

journal_title：Frontiers in immunology

authors： Wolf M,Moser B

更新日期：2012-07-23 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：:During gestation, Toxoplasma gondii infection produces a series of complications including stillbirths, abortions, and congenital malformations. The inhibitory receptor, LILRB4, which is mainly expressed by professional antigen-presenting cells (especially macrophages and dendritic cells) may play an important immune-...

journal_title：Frontiers in immunology

authors： Li Z,Zhao M,Li T,Zheng J,Liu X,Jiang Y,Zhang H,Hu X

更新日期：2017-08-24 00:00:00

abstract：:The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the resistance to Respiratory Syncytial Virus (RSV) infection. In this work, by using macrophages deple...

journal_title：Frontiers in immunology

authors： Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

更新日期：2020-09-29 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing t...

journal_title：Frontiers in immunology

authors： McCaughan GW,Bowen DG,Bertolino PJ

更新日期：2020-09-11 00:00:00

abstract：:The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed...

journal_title：Frontiers in immunology

authors： Grosche L,Knippertz I,König C,Royzman D,Wild AB,Zinser E,Sticht H,Muller YA,Steinkasserer A,Lechmann M

更新日期：2020-04-17 00:00:00

abstract：:The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated that the human FOXP3+ subset is functionally heterogeneous, whereby ...

journal_title：Frontiers in immunology

authors： Bin Dhuban K,Bartolucci S,d'Hennezel E,Piccirillo CA

更新日期：2019-07-18 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their influence on nociceptive processes. Recent studies highlight that...

journal_title：Frontiers in immunology

authors： Kwiatkowski K,Pawlik K,Ciapała K,Piotrowska A,Makuch W,Mika J

更新日期：2020-12-21 00:00:00

abstract：:The host immune response to gastrointestinal (GI) infections, hypersensitivity reactions, or GI cancers comprises numerous pathways that elicit responses on different host cells. Some of these include (1) the stimulation of mast cells via their IgE receptor, (2) the production of antibodies leading to antibody-mediate...

journal_title：Frontiers in immunology

authors： El-Zaatari M,Kao JY

更新日期：2017-01-27 00:00:00

abstract：:Resident memory T cells (TRM) are broadly defined as a population of T cells, which persist in non-lymphoid sites long-term, do not re-enter the circulation, and are distinct from central memory T cells (TCM) and circulating effector memory T cells (TEM). Recent studies have described populations of TRM cells in the s...

journal_title：Frontiers in immunology

authors： Shane HL,Klonowski KD

更新日期：2014-07-08 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. Intriguingly, HERV...

journal_title：Frontiers in immunology

authors： Grandi N,Tramontano E

更新日期：2018-09-10 00:00:00

abstract：:Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 t...

journal_title：Frontiers in immunology

authors： Bowers JS,Majchrzak K,Nelson MH,Aksoy BA,Wyatt MM,Smith AS,Bailey SR,Neal LR,Hammerbacher JE,Paulos CM

更新日期：2017-09-29 00:00:00