Antibodies to Senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model.

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tf...

journal_title：Frontiers in immunology

authors： Pallikkuth S,de Armas L,Rinaldi S,Pahwa S

更新日期：2017-10-23 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.00367.]. ...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-04-03 00:00:00

abstract：:T cells play a critical role in cancer control, but a range of potent immunosuppressive mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity. While various immunotherapies (IMTs) aiming at re-invigorating the T-cell-mediated anti-tumor response, such as immune checkpoint blockad...

journal_title：Frontiers in immunology

authors： Vigano S,Alatzoglou D,Irving M,Ménétrier-Caux C,Caux C,Romero P,Coukos G

更新日期：2019-06-06 00:00:00

abstract：:West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

journal_title：Frontiers in immunology

authors： Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

更新日期：2020-01-23 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00

abstract：:Regulatory T cells play an important role in the control of autoimmune diseases and maintenance of tolerance. In the context of transplantation, regulatory T cells (Tregs) have been proposed as new therapeutic tools that may induce allospecific tolerance toward the graft, avoiding the side effects induced by generaliz...

journal_title：Frontiers in immunology

authors： Alvarez-Salazar EK,Cortés-Hernández A,Arteaga-Cruz S,Alberú-Gómez J,Soldevila G

更新日期：2020-04-02 00:00:00

abstract：:Human pregnancy is accompanied by a mild systemic inflammatory response, which includes the activation of monocytes circulating in maternal blood. This response is exaggerated in preeclampsia, a placental-dependent disorder specific to human pregnancies. We and others showed that placental syncytiotrophoblast membrane...

journal_title：Frontiers in immunology

authors： Joerger-Messerli MS,Hoesli IM,Rusterholz C,Lapaire O

更新日期：2014-04-15 00:00:00

abstract：Purpose:Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective:To evaluate changes in lipoproteins, insulin resistance, mediators of systemi...

journal_title：Frontiers in immunology

authors： Yadav R,Hama S,Liu Y,Siahmansur T,Schofield J,Syed AA,France M,Pemberton P,Adam S,Ho JH,Aghamohammadzadeh R,Dhage S,Donn R,Malik RA,New JP,Jeziorska M,Durrington P,Ammori BA,Soran H

更新日期：2017-11-15 00:00:00

abstract：:Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system...

journal_title：Frontiers in immunology

authors： Huang Z,Aweya JJ,Zhu C,Tran NT,Hong Y,Li S,Yao D,Zhang Y

更新日期：2020-11-05 00:00:00

abstract：:The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-s...

journal_title：Frontiers in immunology

authors： Ashley CL,Abendroth A,McSharry BP,Slobedman B

更新日期：2019-12-11 00:00:00

abstract：:Efficient tuberculosis (TB) control depends on early TB prediction and prevention. Solution to these tasks requires knowledge of TB protection correlates (TB CoPs), i.e., laboratory markers that are mechanistically involved in the protection and which allow to determine how well an individual is protected against TB o...

journal_title：Frontiers in immunology

authors： Lyadova I,Nikitina I

更新日期：2019-05-08 00:00:00

abstract：:The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely toxic in vivo. Recent ...

journal_title：Frontiers in immunology

authors： Vita GM,De Simone G,Leboffe L,Montagnani F,Mariotti D,Di Bella S,Luzzati R,Gori A,Ascenzi P,di Masi A

更新日期：2020-12-08 00:00:00

abstract：:The scavenger receptor SR-F1 binds to and mediates the internalization of a wide range of ligands, and is involved in several immunological processes. We produced recombinant SR-F1 ectodomain and fragments deleted from the last 2 or 5 C-terminal epidermal growth factor-like modules and investigated their role in the b...

journal_title：Frontiers in immunology

authors： Wicker-Planquart C,Dufour S,Tacnet-Delorme P,Bally I,Delneste Y,Frachet P,Housset D,Thielens NM

更新日期：2020-03-31 00:00:00

abstract：:The innate immune system plays a critical early role in host defense against viruses, bacteria, and tumor cells. Until recently, natural killer (NK) cells and lymphoid tissue inducer (LTi) cells were the primary members of the innate lymphocyte family: NK cells form the front-line interface between the external enviro...

journal_title：Frontiers in immunology

authors： Rankin L,Groom J,Mielke LA,Seillet C,Belz GT

更新日期：2013-03-04 00:00:00

abstract：:The close association between cardiovascular pathology and renal dysfunction is well documented and significant. Patients with conventional risk factors for cardiovascular disease like diabetes and hypertension also suffer renal dysfunction. This is unsurprising if the kidney is simply regarded as a "modified blood ve...

journal_title：Frontiers in immunology

authors： Hewitson TD,Holt SG,Smith ER

更新日期：2015-09-17 00:00:00

abstract：:The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

journal_title：Frontiers in immunology

authors： Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

更新日期：2017-03-07 00:00:00

abstract：:Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts resembling TCR conver...

journal_title：Frontiers in immunology

authors： Looney TJ,Topacio-Hall D,Lowman G,Conroy J,Morrison C,Oh D,Fong L,Zhang L

更新日期：2020-01-09 00:00:00

abstract：:Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

journal_title：Frontiers in immunology

authors： Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

更新日期：2017-12-18 00:00:00

abstract：:Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Cons...

journal_title：Frontiers in immunology

authors： Saul L,Mair I,Ivens A,Brown P,Samuel K,Campbell JDM,Soong DY,Kamenjarin N,Mellanby RJ

更新日期：2019-03-28 00:00:00

abstract：:A 65-year-old Italian physician affected by Familial Mediterranean fever (FMF) was hospitalized due to progressive abdominal enlargement, which had begun 6 months before admission. Physical examination revealed ascites and bilateral leg edema. Abdominal CT scan showed ascitic fluid and extensive multiple peritoneal im...

journal_title：Frontiers in immunology

authors： Talerico R,Cardillo C,De Vito F,Schinzari F,Soldato M,Giustiniani MC,Verrecchia E,Manna R

更新日期：2020-05-13 00:00:00

abstract：:Laboratory of genetics and physiology 2 (LGP2) is a key component of RIG-I-like receptors (RLRs). However, the lack of the caspase recruitment domains (CARDs) results in its controversial functional performance as a negative or positive regulator in antiviral responses. Especially, no sufficient evidence uncovers the ...

journal_title：Frontiers in immunology

authors： Rao Y,Wan Q,Yang C,Su J

更新日期：2017-03-27 00:00:00

abstract：:All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immunity and nutrient conver...

journal_title：Frontiers in immunology

authors： Montalban-Arques A,De Schryver P,Bossier P,Gorkiewicz G,Mulero V,Gatlin DM 3rd,Galindo-Villegas J

更新日期：2015-10-09 00:00:00

abstract：:Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

journal_title：Frontiers in immunology

authors： Liu R,Nikolajczyk BS

更新日期：2019-07-17 00:00:00

abstract：:The immune response of a host to a pathogen is typically described as either innate or adaptive. The innate form of the immune response is conserved across all organisms, including insects. Previous and recent research has focused on the nature of the insect immune system and the results imply that the innate immune r...

journal_title：Frontiers in immunology

authors： Cooper D,Eleftherianos I

更新日期：2017-05-09 00:00:00

abstract：:Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs drive inflammatory responses in skin through activation of epidermal...

journal_title：Frontiers in immunology

authors： Shao S,Fang H,Dang E,Xue K,Zhang J,Li B,Qiao H,Cao T,Zhuang Y,Shen S,Zhang T,Qiao P,Li C,Gudjonsson JE,Wang G

更新日期：2019-04-05 00:00:00

abstract：:Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immun...

journal_title：Frontiers in immunology

authors： Jeliazkov JR,Sljoka A,Kuroda D,Tsuchimura N,Katoh N,Tsumoto K,Gray JJ

更新日期：2018-03-02 00:00:00

abstract：:Recently, a second individual (the "London patient") with HIV-1 infection and concomitant leukemia was cured of both diseases by a conditioning myeloablative regimen followed by transplantation of stem cells bearing the homozygous CCR5 Δ32 mutation. The substantial risks and cost associated with this procedure render ...

journal_title：Frontiers in immunology

authors： Gavegnano C,Savarino A,Owanikoko T,Marconi VC

更新日期：2019-10-04 00:00:00

abstract：:The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophag...

journal_title：Frontiers in immunology

authors： Jacquin E,Apetoh L

更新日期：2018-05-09 00:00:00

abstract：:Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. Methods: We performed two studies in southern coastal Kenya. In a birth ...

journal_title：Frontiers in immunology

authors： Stoffel NU,Uyoga MA,Mutuku FM,Frost JN,Mwasi E,Paganini D,van der Klis FRM,Malhotra IJ,LaBeaud AD,Ricci C,Karanja S,Drakesmith H,King CH,Zimmermann MB

更新日期：2020-07-13 00:00:00