Abstract:
:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Pallikkuth S,de Armas L,Rinaldi S,Pahwa Sdoi
10.3389/fimmu.2017.01380subject
Has Abstractpub_date
2017-10-23 00:00:00pages
1380issn
1664-3224journal_volume
8pub_type
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.3389/fimmu.2019.00917.]. ...
journal_title:Frontiers in immunology
pub_type: 已发布勘误
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.597858
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.507092
更新日期:2020-12-08 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2019.02423
更新日期:2019-10-11 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Frontiers in immunology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2018-02-07 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.559746
更新日期:2020-11-24 00:00:00