Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk.

abstract：:Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the scaffold and the prot...

journal_title：Frontiers in immunology

authors： Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

更新日期：2020-09-11 00:00:00

abstract：:Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or pro-oxidants. We show that depleting macrophages of 99% of GSH does ...

journal_title：Frontiers in immunology

authors： Diotallevi M,Checconi P,Palamara AT,Celestino I,Coppo L,Holmgren A,Abbas K,Peyrot F,Mengozzi M,Ghezzi P

更新日期：2017-09-29 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:Efficient induction of effector and long-term protective antigen-specific CD8+ T memory response by vaccination is essential to eliminate malignant and pathogen-infected cells. Intracellular infectious bacteria, including Listeria monocytogenes, have been considered potent vectors to carry multiple therapeutic protein...

journal_title：Frontiers in immunology

authors： Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP

更新日期：2020-04-09 00:00:00

abstract：:Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

journal_title：Frontiers in immunology

authors： Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

更新日期：2019-08-08 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger adults. Unfortunately, influenza vaccine responses tend to be impaired in older adults due to aging of the immune system (immunosenescence). Latent infection with cy...

journal_title：Frontiers in immunology

authors： van den Berg SPH,Wong A,Hendriks M,Jacobi RHJ,van Baarle D,van Beek J

更新日期：2018-01-29 00:00:00

abstract：:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular mat...

journal_title：Frontiers in immunology

authors： Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

更新日期：2019-02-15 00:00:00

abstract：:β-glucan, the most abundant fungal cell wall polysaccharide, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study of this molecule has been motivated by its importance as a pathogen-associated molecular pattern upon fungal...

journal_title：Frontiers in immunology

authors： Camilli G,Tabouret G,Quintin J

更新日期：2018-04-16 00:00:00

abstract：:The potential of natural killer (NK) cells to target numerous malignancies in vitro has been well documented; however, only limited success has been seen in the clinic. Although NK cells prove non-toxic and safe regardless of the cell numbers injected, there is often little persistence and expansion observed in a pati...

journal_title：Frontiers in immunology

authors： Domogala A,Madrigal JA,Saudemont A

更新日期：2015-06-03 00:00:00

abstract：:The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight ...

journal_title：Frontiers in immunology

authors： Pednekar L,Pathan AA,Paudyal B,Tsolaki AG,Kaur A,Abozaid SM,Kouser L,Khan HA,Peerschke EI,Shamji MH,Stenbeck G,Ghebrehiwet B,Kishore U

更新日期：2016-12-13 00:00:00

abstract：:Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...

journal_title：Frontiers in immunology

authors： Hussain K,Letley DP,Greenaway AB,Kenefeck R,Winter JA,Tomlinson W,Rhead J,Staples E,Kaneko K,Atherton JC,Robinson K

更新日期：2016-03-07 00:00:00

abstract：:The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using ...

journal_title：Frontiers in immunology

authors： Arulraj T,Binder SC,Robert PA,Meyer-Hermann M

更新日期：2019-09-06 00:00:00

abstract：:Earlier data suggest that progesterone-induced blocking factor (PIBF) is involved in implantation. The present study therefore aims to investigate the consequences of functional PIBF deficiency during the peri-implantation period. CD1 female mice were injected intraperitoneally with 2 μg anti-PIBF monoclonal antibody ...

journal_title：Frontiers in immunology

authors： Csabai T,Pallinger E,Kovacs AF,Miko E,Bognar Z,Szekeres-Bartho J

更新日期：2020-03-11 00:00:00

abstract：:Elimination of potential self-reactive T cells in the thymus is crucial for preventing the onset of autoimmune diseases. Epithelial cell subsets localized in thymic medulla [medullary thymic epithelial cells (mTECs)] contribute to this process by supplying a wide range of self-antigens that are otherwise expressed in ...

journal_title：Frontiers in immunology

authors： Akiyama T,Shinzawa M,Qin J,Akiyama N

更新日期：2013-08-26 00:00:00

abstract：:Background: Although immunotherapy has emerged as the "next generation" of cancer treatments, it has not yet been shown to be successful in the treatment of patients with prostate cancer, for whom therapeutic options remain limited to radiotherapy and androgen (hormone) deprivation therapy. Previous studies have shown...

journal_title：Frontiers in immunology

authors： Hood SP,Foulds GA,Imrie H,Reeder S,McArdle SEB,Khan M,Pockley AG

更新日期：2019-01-25 00:00:00

abstract：:The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the d...

journal_title：Frontiers in immunology

authors： Fleri W,Paul S,Dhanda SK,Mahajan S,Xu X,Peters B,Sette A

更新日期：2017-03-14 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：:Understanding affinity maturation of antibodies that can target many variants of HIV-1 is important for vaccine development. While the antigen-binding site of antibodies is known to mutate throughout the co-evolution of antibodies and viruses in infected individuals, the roles of the mutations in the antibody framewor...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-07-17 00:00:00

abstract：:Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated. In the prevailing view, Aire serves mainly as a direct inducer of tissue-specific antigens. However, there is a growing amount of ev...

journal_title：Frontiers in immunology

authors： Laan M,Peterson P

更新日期：2013-10-11 00:00:00

abstract：:Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a "high inflammatory/immune biotype." Recent studies implicate both complement and macrophages i...

journal_title：Frontiers in immunology

authors： Purves-Tyson TD,Robinson K,Brown AM,Boerrigter D,Cai HQ,Weissleder C,Owens SJ,Rothmond DA,Shannon Weickert C

更新日期：2020-09-29 00:00:00

abstract：:Autologous chimeric antigen receptor-modified (CAR) T cells with specificity for CD19 showed potent antitumor efficacy in clinical trials against relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Contrary to T cells, natural killer (NK) cells kill their targets in a non-antigen-specific manner and d...

journal_title：Frontiers in immunology

authors： Müller S,Bexte T,Gebel V,Kalensee F,Stolzenberg E,Hartmann J,Koehl U,Schambach A,Wels WS,Modlich U,Ullrich E

更新日期：2020-01-24 00:00:00

abstract：:Neutrophil extracellular traps (NETs), DNA webs released into the extracellular environment by activated neutrophils, are thought to play a key role in the entrapment and eradication of microbes. However, NETs are highly cytotoxic and a likely source of autoantigens, suggesting that NET release is tightly regulated. N...

journal_title：Frontiers in immunology

authors： Majewski P,Majchrzak-Gorecka M,Grygier B,Skrzeczynska-Moncznik J,Osiecka O,Cichy J

更新日期：2016-06-30 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear receptor (NR) family of transcription factors have been reported to aff...

journal_title：Frontiers in immunology

authors： Tel-Karthaus N,Kers-Rebel ED,Looman MW,Ichinose H,de Vries CJ,Ansems M

更新日期：2018-08-03 00:00:00

abstract：:Background: Alemtuzumab is a highly effective drug for the treatment of multiple sclerosis (MS), characterized by specific patterns of depletion and repopulation. As an induction-like treatment concept, two mandatory infusion courses can inhibit long-term disease activity in the majority of patients, and additional co...

journal_title：Frontiers in immunology

authors： Akgün K,Blankenburg J,Marggraf M,Haase R,Ziemssen T

更新日期：2020-01-31 00:00:00

abstract：:Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfun...

journal_title：Frontiers in immunology

authors： Klingemann H,Boissel L,Toneguzzo F

更新日期：2016-03-14 00:00:00

abstract：:Adenosine triphosphate (ATP) is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activation. However, it is unclear whether AMPK s...

journal_title：Frontiers in immunology

authors： Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

更新日期：2016-12-12 00:00:00