An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response.

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as well in murine Mtb infection models. However, the interaction of mycobacteria with MDSCs and its role in TB infection is not well studied. Here, we investigated the role of Ca...

journal_title：Frontiers in immunology

authors： John V,Kotze LA,Ribechini E,Walzl G,Du Plessis N,Lutz MB

更新日期：2019-12-03 00:00:00

abstract：:Adipose tissue performs immunoregulatory functions in addition to fat storage. Various T cells in different fat depots either help maintain metabolic homeostasis under healthy conditions or contribute to metabolic disorders in pathological conditions such as obesity, diabetes, cardiovascular diseases, or even cancer. ...

journal_title：Frontiers in immunology

authors： Wang Q,Wu H

更新日期：2018-10-30 00:00:00

abstract：:A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of alternate booster regimens on the immune responses to a candidate HIV-...

journal_title：Frontiers in immunology

authors： Kratochvil S,McKay PF,Kopycinski JT,Bishop C,Hayes PJ,Muir L,Pinder CL,Cizmeci D,King D,Aldon Y,Wines BD,Hogarth PM,Chung AW,Kent SJ,Held K,Geldmacher C,Dally L,Santos NS,Cole T,Gilmour J,Fidler S,Shattock RJ

更新日期：2017-05-24 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the ...

journal_title：Frontiers in immunology

authors： Lawless N,Vegh P,O'Farrelly C,Lynn DJ

更新日期：2014-11-27 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56++CD16...

journal_title：Frontiers in immunology

authors： Huenecke S,Cappel C,Esser R,Pfirrmann V,Salzmann-Manrique E,Betz S,Keitl E,Banisharif-Dehkordi J,Bakhtiar S,Königs C,Jarisch A,Soerensen J,Ullrich E,Klingebiel T,Bader P,Bremm M

更新日期：2017-02-10 00:00:00

abstract：:Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination (CSR) defects associated with hyper-...

journal_title：Frontiers in immunology

authors： Jhamnani RD,Nunes-Santos CJ,Bergerson J,Rosenzweig SD

更新日期：2018-09-26 00:00:00

abstract：Background:The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use of anti-PD-L1/PD-1 antibodies in multiple myeloma (MM) patients still remains debated, at least in part because of discordant literature data on PD-L1...

journal_title：Frontiers in immunology

authors： Costa F,Vescovini R,Marchica V,Storti P,Notarfranchi L,Dalla Palma B,Toscani D,Burroughs-Garcia J,Catarozzo MT,Sammarelli G,Giuliani N

更新日期：2021-01-08 00:00:00

abstract：:Tumor necrosis factor-α inhibitors (TNFis) have revolutionized the management of rheumatoid arthritis (RA), however despite considerable progress, only a small proportion of patients maintain long-term clinical response. Selection of, and switching between, biologics is mainly empirical, experiential, and not evidence...

journal_title：Frontiers in immunology

authors： Mehta P,Manson JJ

更新日期：2020-04-07 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells essential for the induction of adaptive immune responses. Their unprecedented ability to present antigens to T cells has made them excellent targets for vaccine development. In the last years, a new technology based on antigen delivery directly to different DC subsets...

journal_title：Frontiers in immunology

authors： Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

更新日期：2017-12-04 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:Drugs formulated from monoclonal antibodies (mAbs) are clinically effective in various diseases. Repeated administration of mAbs, however, elicits an immune response in the form of anti-drug-antibodies (ADA), thereby reducing the drug's efficacy. Notwithstanding their importance, the molecular landscape of ADA and the...

journal_title：Frontiers in immunology

authors： Vaisman-Mentesh A,Rosenstein S,Yavzori M,Dror Y,Fudim E,Ungar B,Kopylov U,Picard O,Kigel A,Ben-Horin S,Benhar I,Wine Y

更新日期：2019-12-18 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor nec...

journal_title：Frontiers in immunology

authors： Roberts CA,Dickinson AK,Taams LS

更新日期：2015-11-19 00:00:00

abstract：:Influenza A viruses (IAVs) continue to pose major risks of morbidity and mortality during yearly epidemics and periodic pandemics. The genomic instability of IAV allows it to evade adaptive immune responses developed during prior infection. Of particular concern are pandemics which result from wholesale incorporation ...

journal_title：Frontiers in immunology

authors： Hsieh IN,De Luna X,White MR,Hartshorn KL

更新日期：2018-06-13 00:00:00

abstract：:Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is currently being explored in in...

journal_title：Frontiers in immunology

authors： Bassolas-Molina H,Raymond E,Labadia M,Wahle J,Ferrer-Picón E,Panzenbeck M,Zheng J,Harcken C,Hughes R,Turner M,Smith D,Calderón-Gómez E,Esteller M,Carrasco A,Esteve M,Dotti I,Corraliza AM,Masamunt MC,Arajol C,Guardio

更新日期：2018-10-22 00:00:00

abstract：:The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease. Complement proteins, regulators, and receptors are widely expressed throughout the CNS and, in many ...

journal_title：Frontiers in immunology

authors： Carpanini SM,Torvell M,Morgan BP

更新日期：2019-03-04 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

journal_title：Frontiers in immunology

authors： Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

更新日期：2013-09-03 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Adenosine is a potent immunosuppressive purine metabolite contributing to the pathogenesis of solid tumors. Extracellular adenosine signals on tumor-infiltrating NK cells to inhibit their proliferation, maturation, and cytotoxic function. Cytokine priming imparts upon NK cells distinct activation statuses, which modul...

journal_title：Frontiers in immunology

authors： Chambers AM,Wang J,Lupo KB,Yu H,Atallah Lanman NM,Matosevic S

更新日期：2018-10-30 00:00:00

abstract：:Gamma delta (γδ) T cells, which possess potent cytotoxicity against a wide range of cancer cells, have become a potential avenue for adoptive immunotherapy. Decitabine (DAC) has been reported to enhance the immunogenicity of tumor cells, thereby reinstating endogenous immune recognition and tumor lysis. However, DAC h...

journal_title：Frontiers in immunology

authors： Niu C,Li M,Zhu S,Chen Y,Zhou L,Xu D,Li W,Cui J,Liu Y,Chen J

更新日期：2018-03-26 00:00:00

abstract：:The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various...

journal_title：Frontiers in immunology

authors： Motran CC,Silvane L,Chiapello LS,Theumer MG,Ambrosio LF,Volpini X,Celias DP,Cervi L

更新日期：2018-04-04 00:00:00

abstract：:Among all T and NK cell subsets, regulatory T (Treg) cells typically respond to the lowest concentrations of IL-2 due to elevated surface expression of the IL-2R alpha chain (IL2RA; CD25) and the high affinity IL-2 receptor (IL-2R) complex. This enhanced sensitivity forms the basis for low-dose (LD) IL-2 therapy for t...

journal_title：Frontiers in immunology

authors： Ghelani A,Bates D,Conner K,Wu MZ,Lu J,Hu YL,Li CM,Chaudhry A,Sohn SJ

更新日期：2020-06-05 00:00:00

abstract：:Immunotherapy using checkpoint blockade has revolutionized cancer treatment, improving patient survival and quality of life. Nevertheless, the clinical outcomes of such immunotherapy are highly heterogeneous between patients. Depending on the cancer type, the patient response rates to this immunotherapy are limited to...

journal_title：Frontiers in immunology

authors： Chuang YC,Tseng JC,Huang LR,Huang CM,Huang CF,Chuang TH

更新日期：2020-05-29 00:00:00

abstract：:Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

journal_title：Frontiers in immunology

authors： Dougan M

更新日期：2017-11-15 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play a crucial role in regulating the intestinal immune response during colitis. We previously revealed an essential role of MDSC in promoting TH17 cell polarization, which was found to be arginase-1 (Arg-1)-dependent; however, the underlying mechanism remains obscure. Here we r...

journal_title：Frontiers in immunology

authors： Ma Z,Zhen Y,Hu C,Yi H

更新日期：2020-04-22 00:00:00

abstract：:Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs) and dendritic cells (DCs), but also in controlling the function ...

journal_title：Frontiers in immunology

authors： Zhan Y,Lew AM,Chopin M

更新日期：2019-11-15 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00